UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                              WASHINGTON, DC 20549

                                   FORM 12b-25                   SEC FILE NUMBER
                                                                    0-16132
                         NOTIFICATION OF LATE FILING              CUSIP NUMBER
                                                                   15102010-4

(CHECK ONE):  |X|  Form 10-K     |_|  Form 20-F    |_|  Form 11-K    
              |_|  Form 10-Q     |_| Form N-SAR    |_| Form N-CSR

For Period Ended:   December 31, 2004
[  ] Transition Report on Form 10-K
[  ] Transition Report on Form 20-F
[  ] Transition Report on Form 11-K
[  ] Transition Report on Form 10-Q
[  ] Transition Report on Form N-SAR
For the Transition Period Ended: _______________________________________________

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  READ ATTACHED INSTRUCTION SHEET BEFORE PREPARING FORM. PLEASE PRINT OR TYPE.
      Nothing in this form shall be construed to imply that the Commission
                 has verified any information contained herein.
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If the notification relates to a portion of the filing checked above, identify
the item(s) to which the notification relates:


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                         PART I - REGISTRANT INFORMATION


Celgene Corporation
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Full name of registrant


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Former name if applicable


86 Morris Avenue
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Address of principal executive office (STREET AND NUMBER)


Summit, New Jersey 07901
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City, state and zip code


                        PART II - RULE 12b-25(b) AND (c)

         If the subject report could not be filed without unreasonable effort or
expense and the registrant seeks relief pursuant to Rule 12b-25(b), the
following should be completed. (Check box if appropriate.)

         |X|     (a)  The reasons described in reasonable detail in Part III of
                      this form could not be eliminated without unreasonable
                      effort or expense;

         |X|     (b)  The subject annual report, semi-annual report, transition
                      report on Form 10-K, Form 20-F, Form 11-K, Form N-SAR or
                      Form N-CSR or portion thereof, will be filed on or before
                      the fifteenth calendar day following the prescribed due
                      date; or the subject quarterly report or transition report
                      on Form 10-Q, or portion thereof, will be filed on or
                      before the fifth calendar day following the prescribed due
                      date; and

         |_|     (c)  The accountant's statement or other exhibit required by
                      Rule 12b-25(c) has been attached if applicable.





                              PART III - NARRATIVE

         State below in reasonable detail the reasons why Forms 10-K, 20-F,
11-K, 10-Q, N-SAR, N-CSR, or the transition report or portion thereof, could not
be filed within the prescribed time period.

         As previously announced by Celgene Corporation (the "Company") in its
press release dated January 27, 2005, which has been filed as Exhibit 99.1 to
the Company's Current Report on Form 8-K filed on January 27, 2005, the Company
has been reviewing its accounting treatment for certain warrants to purchase
common stock received by the Company from EntreMed, Inc. ("EntreMed") in
connection with several agreements entered into with EntreMed on December 31,
2002 relating to, among other things, the termination of patent litigation
between the two companies. Based on the Company's analysis at that time--an
analysis as to which the Company at the time had disclosed to its independent
auditors all the relevant facts and as to which the independent auditors had
concurred--the Company expensed the entire amount paid to EntreMed in connection
with those agreements, including its equity investment and the warrants, through
its statement of operations (income statement) as of December 31, 2002. The
Company previously accounted for the warrants acquired in the transaction using
the equity method of accounting under APB 18 and has now concluded that it will
account for the warrants as derivatives under SFAS No. 133. In addition, at the
time of the transaction with EntreMed in December, 2002, the Company fully
reserved its equity investment in the EntreMed preferred stock that it acquired
in such transaction as an other than temporary impairment. This accounting
treatment, for which the Company at the time had also disclosed to its
independent auditors all the relevant facts, had also been concurred in by such
independent auditors at the time. The Company has now concluded that it will
reverse the reserve taken at that time and record its equity in the net losses
of EntreMed as reported in each quarter of 2003 until such time as its equity
investment is zero (Third Quarter, 2003). To reflect these accounting changes,
the Company will restate its financial results for the years ended December 31,
2003 and 2002, as such will be included in its Annual Report on Form 10K for the
year ended December 31, 2004. These changes have resulted in a delay of several
days in the completion of the review of the Company's financial statements.

                          PART IV - OTHER INFORMATION

(1)       Name and telephone number of person to contact in regard to this
          notification

          James R. Swenson                 (908)                  673-9607
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          (Name)                        (Area Code)           (Telephone Number)

(2)       Have all other periodic reports required under Section 13 or 15(d) of
          the Securities Exchange Act of 1934 or Section 30 of the Investment
          Company Act of 1940 during the preceding 12 months or for such shorter
          period that the registrant was required to file such report(s) been
          filed? If the answer is no, identify report(s).

                                                                |X| Yes   |_| No

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(3)       Is it anticipated that any significant change in results of operations
          from the corresponding period for the last fiscal year will be
          reflected by the earnings statements to be included in the subject
          report or portion thereof?

                                                                |X| Yes   |_| No

          If so: attach an explanation of the anticipated change, both
          narratively and quantitatively, and, if appropriate, state the reasons
          why a reasonable estimate of the results cannot be made.

          An explanation of the anticipated change is contained in a press
          release issued by the Company, dated January 27, 2005, and which is
          incorporated herein by reference to Exhibit 99.1 to the Company's
          Current Report on Form 8-K, dated January 27, 2005.



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                               CELGENE CORPORATION
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                  (Name of Registrant as Specified in Charter)

          Has caused this notification to be signed on its behalf by the
undersigned thereunto duly authorized.


          Date: March 16, 2005                     By: /s/ Robert J. Hugin
                -----------------                      -------------------------
                                                       Robert J. Hugin
                                                       Senior Vice President and
                                                       Chief Financial Officer


INSTRUCTION: The form may be signed by an executive officer of the registrant or
by any other duly authorized representative. The name and title of the person
signing the form shall be typed or printed beneath the signature. If the
statement is signed on behalf of the registrant by an authorized representative
(other than an executive officer), evidence of the representative's authority to
sign on behalf of the registrant shall be filed with the form.

            INTENTIONAL MISSTATEMENTS OR OMISSIONS OF FACT CONSTITUTE
               FEDERAL CRIMINAL VIOLATIONS (SEE 18 U.S.C. 1001).