SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
SCHEDULE 13G
Under the Securities Exchange Act of 1934
(Amendment No. )*
EPIX Pharmaceuticals, Inc.
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(Name of Issuer)
Common Stock
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(Title of Class of Securities)
26881Q 30 9
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(CUSIP Number)
December 18, 2006
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(Date of Event Which Requires Filing of this Statement)
Check the following box to designate the rule pursuant to which this Schedule is
filed:
Rule 13d-1(b)
Rule 13d-1(c)
x Rule 13d-1(d)
*The remainder of this cover page shall be filled our for a reporting person's
initial filing on this form with respect to the subject class of securities, and
for any subsequent amendment containing information which would alter the
disclosures provided in a prior cover page.
The information required in the remainder of this cover page shall not be deemed
to be "filed" for the purpose of Section 18 of the Securities Exchange Act of
1934 ("Act") or otherwise subject to the liabilities of that section of the Act
but shall be subject to all other provisions of the Act (however, see the
Notes).
(Continued on following page(s))
CUSIP NO. 13G
1 NAME OF REPORTING PERSON
S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON
GlaxoSmithKline plc
2 CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (See Instructions)
(a) [ ]
(b) [ ]
3 SEC USE ONLY
4 CITIZENSHIP OR PLACE OF ORGANIZATION
England and Wales
5 SOLE VOTING POWER
NUMBER OF 4,266,795
SHARES
BENEFICIALLY 6 SHARED VOTING POWER
OWNED BY -0-
EACH
REPORTING 7 SOLE DISPOSITIVE POWER
PERSON 4,266,795
WITH
8 SHARED DISPOSITIVE POWER
-0-
9 AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
4,266,795
10 CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES
[ ]
11 PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9
13.3%
12 TYPE OF REPORTING PERSON*
CO
*SEE INSTRUCTION BEFORE FILLING OUT!
CUSIP NO. 26881Q 30 9 13G
Item 1. (a). Name of Issuer:
EPIX Pharmaceuticals, Inc.
(b). Address of Issuer's Principal Executive
Offices:
4 Maguire Road
Lexington, MA 02421
Item 2. (a). Names of Person Filing:
GlaxoSmithKline plc
(b). Address of Principal Business Office:
980 Great West Road
Brentford
Middlesex
TW8 9GS ENGLAND
(c). Citizenship:
England and Wales
(d). Title of Class of Securities:
Common stock.
(e). CUSIP Number:
26881Q 30 9
Item 3. Not Applicable.
Item 4. Ownership.
The information in items 1 and 5 through 11
on the cover pages (page 2) on Schedule 13G
is hereby incorporated by reference.
Item 5. Ownership of Five Percent or Less of a
Class:
If this statement is being filed to report
the fact that as of the date hereof the
reporting person has ceased to be the
beneficial owner of more than five percent
of the class of securities, check the
following [ ].
Item 6. Ownership of More Than Five Percent on
Behalf of Another Person:
Shares held by following wholly-owned
subsidiaries of Reporting Person:
Glaxo Group Limited 1,629,689
SmithKline Beecham Corporation 1,379,338
S.R. One, Limited 1,257,768
Item 7. Identification and Classification of
Subsidiaries Which Acquired the Security
Being Reported on by the Parent Holding
Company:
Not applicable.
Item 8. Identification and Classification of Members
of the Group:
Not applicable.
Item 9. Notice of Dissolution of Group:
Not applicable
Item 10. Certification:
By signing below I certify that, to the best
of my knowledge and belief, the securities
referred to above were acquired and are not
held for the purpose of or with the effect
of changing or influencing the control of
the issuer of such securities and were not
acquired in connection with or as a
participant in any transaction having such
purpose or effect.
Signature:
After reasonable inquiry and to the best of
my knowledge and belief, I certify that the
information set
forth in this statement is true, complete
and correct.
GLAXOSMITHKLINE PLC
By: /s/ Victoria A. Whyte
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Victoria A. Whyte
Deputy Secretary
Dated: December 21, 2006