UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549


SCHEDULE 13G

Under the Securities Exchange Act of 1934


Amendment No.: 3*


Name of Issuer: Celgene Corporation


Title of Class of Securities: Common Stock


CUSIP Number: 15102010-4


Date of Event Which Requires Filing of this Statement: 2/28/2007


Check the appropriate box to designate the rule pursuant to which
this Schedule is filed.

[X] Rule 13d-1(b)
[ ] Rule 13d-1(c)
[ ] Rule 13d-1(d)

* The remainder of this cover page shall be filled out for a
reporting person's initial filing on this form with respect to the
subject class of securities, and for any subsequent amendment
containing information which would alter the disclosures provided
in a prior cover page.

The information required in the remainder of this cover page shall
not be deemed to be "filed" for the purpose of Section 18 of the
Securities Exchange Act of 1934 ("Act") or otherwise subject to
the liabilities of that section of the Act but shall be subject to
all other provisions of the Act (however, see the Notes).


CUSIP No.: 15102010-4

1.  NAME OF REPORTING PERSON
    S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON
    Janus Capital Management LLC
    EIN #75-3019302

2.  CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP
    a.   ___
    b.   ___

3.  SEC USE ONLY

4.  CITIZENSHIP OR PLACE OF ORGANIZATION
         Delaware

NUMBER OF SHARES BENEFICIALLY OWNED BY EACH REPORTING PERSON WITH:

    5.   SOLE VOTING POWER
         28,441,965**

    6.   SHARED VOTING POWER
         9,837,418**

    7.   SOLE DISPOSITIVE POWER
         28,441,965**

    8.   SHARED DISPOSITIVE POWER
         9,837,418**

    9.   AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING
PERSON
         38,279,383**

    10.  CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES
CERTAIN SHARES
         Not applicable

11. PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)
    10.1%**

12. TYPE OF REPORTING PERSON
    IA, HC

**  See Item 4 of this filing


Item 1.

    (a). Name of Issuer: Celgene Corporation ("Celgene")

    (b). Address of Issuer's Principal Executive Offices:

         86 Morris Avenue
         Summit, NJ 07901

Item 2.

    (a).-(c). Name, Principal Business Address, and Citizenship of
Persons
              Filing:

         (1)  Janus Capital Management LLC ("Janus Capital")
              151 Detroit Street
              Denver, Colorado  80206
              Citizenship:  Delaware

    (d). Title of Class of Securities:  Common Stock

    (e). CUSIP Number:  15102010-4

Item 3.

This statement is filed pursuant to Rule 13d-1 (b) or 13d-2(b) and
the person filing, Janus Capital, is an investment adviser in
accordance with Section 240.13d-1(b)(ii)(E) as well as a parent
holding company/control person in accordance with Section 240.13d-
1(b)(ii)(G).  See Item 4 for additional information.

Item 4.  Ownership

The information in items 1 and 5 through 11 on the cover page(s)
on Schedule 13G is hereby incorporated by reference.

Janus Capital has an indirect 82.5% ownership stake in Enhanced
Investment Technologies LLC ("INTECH") and an indirect 30%
ownership stake in Perkins, Wolf, McDonnell and Company, LLC
("Perkins Wolf").  Due to the above ownership structure, holdings
for Janus Capital, Perkins Wolf and INTECH are aggregated for
purposes of this filing. Janus Capital, Perkins Wolf and INTECH
are registered investment advisers, each furnishing investment
advice to various investment companies registered under Section 8
of the Investment Company Act of 1940 and to individual and
institutional clients (collectively referred to herein as "Managed
Portfolios").

As a result of its role as investment adviser or sub-adviser to
the Managed Portfolios, Janus Capital may be deemed to be the
beneficial owner of 28,441,965 shares or 7.5% of the shares
outstanding of Celgene Common Stock held by such Managed
Portfolios.  However, Janus Capital does not have the right to
receive any dividends from, or the proceeds from the sale of, the
securities held in the Managed Portfolios and disclaims any
ownership associated with such rights.

As a result of its role as investment adviser or sub-adviser to
the Managed Portfolios, INTECH may be deemed to be the beneficial
owner of 9,837,418 shares
or 2.6% of the shares outstanding of Celgene Common Stock held by
such Managed Portfolios.  However, INTECH does not have the right
to receive any dividends
from, or the proceeds from the sale of, the securities held in the
Managed Portfolios and disclaims any ownership associated with
such rights.

Item 5.  Ownership of Five Percent or Less of a Class

Not applicable.

Item 6.  Ownership of More than Five Percent on Behalf of Another
Person

The Managed Portfolios, set forth in Item 4 above, have the right
to receive all dividends from, and the proceeds from the sale of,
the securities held in their respective accounts.

The interest of any one such person does not exceed 5% of the
class of securities.

These shares were acquired in the ordinary course of business, and
not with the purpose of changing or influencing control of the
Issuer.

Item 7.  Identification and Classification of the Subsidiary Which
Acquired the Security Being Reported on by the Parent Holding
Company

INTECH is an indirect subsidiary of Janus Capital (Janus Capital
has a indirect 82.5% ownership stake) and is a registered
investment adviser furnishing investment advice to various
investment companies registered under Section 8 of the Investment
Company Act of 1940 and to individual and institutional clients.

Item 8.  Identification and Classification of Members of the Group

Not applicable.

Item 9.  Notice of Dissolution of Group

Not applicable.

Item 10. Certification

By signing below I certify that, to the best of my knowledge and
belief, the securities referred to above were acquired in the
ordinary course of business and were not acquired for the purpose
of and do not have the effect of changing or influencing the
control of the issuer of such securities and were not acquired in
connection with or as a participant in any transaction having such
purposes or effect.


SIGNATURES

After reasonable inquiry and to the best of my knowledge and
belief, I certify that the information set forth in this statement
is true, complete and correct.

JANUS CAPITAL MANAGEMENT LLC

By  /s/  David R. Kowalski                     3/12/2007
  David R. Kowalski,                              Date
    Senior Vice President and CCO

ENHANCED INVESTMENT TECHNOLOGIES LLC

By  /s/  David R. Kowalski                   3/12/2007
    David R. Kowalski                             Date
       Vice President