UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                              WASHINGTON, DC 20549

                                  ------------


                                    FORM 8-K

                                 CURRENT REPORT
                     PURSUANT TO SECTION 13 OR 15(D) OF THE
                         SECURITIES EXCHANGE ACT OF 1934


        Date of report (Date of earliest event reported): April 20, 2006


                       COMPUTER PROGRAMS AND SYSTEMS, INC.
               (Exact Name of Registrant as Specified in Charter)


           Delaware                  000-49796               74-3032373
 (State or Other Jurisdiction    (Commission File          (IRS Employer
       of Incorporation)              Number)            Identification No.)

           6600 Wall Street,                                   36695
           Mobile, Alabama                                   (Zip Code)
   (Address of Principal Executive
              Offices)

                                 (251) 639-8100
              (Registrant's telephone number, including area code)


                                       N/A
          (Former Name or Former Address, if Changed Since Last Report)

Check the appropriate box below if the Form 8-K filing is intended to
simultaneously satisfy the filing obligation of the registrant under any of the
following provisions:


     |_|  Written communications pursuant to Rule 425 under the Securities Act
(17 CFR 230.425)

     |_|  Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17
CFR 240.14a-12)

     |_|  Pre-commencement communications pursuant to Rule 14d-2(b) under the
Exchange Act (17 CFR 240.14d-2(b))

     |_|  Pre-commencement communications pursuant to Rule 13e-4(c) under the
Exchange Act (17 CFR 240.13e-4(c))






Item 2.02.   Results of Operations and Financial Condition.

     On April 20, 2006, Computer Programs and Systems, Inc. ("CPSI") issued a
press release announcing financial information for its fiscal first quarter
ended March 31, 2006. The press release is attached as Exhibit 99.1 to this Form
8-K and is furnished to, but not filed with, the Commission.


Item 9.01.   Financial Statements and Exhibits.

(d)    Exhibits.

       Exhibit Number          Exhibit
       --------------          -------

       99.1                    Press Release dated April 20, 2006.






                                   SIGNATURES

     Pursuant to the requirements of the Securities Exchange Act of 1934, the
Registrant has duly caused this report to be signed on its behalf by the
undersigned hereunto duly authorized.



                                      COMPUTER PROGRAMS AND
                                      SYSTEMS, INC.

                                      By:  /s/ David A. Dye
                                           -------------------------------------
                                           David A. Dye
                                           President and Chief Executive Officer


Dated: April 20, 2006






                                INDEX TO EXHIBITS


Exhibit Number                       Exhibit
--------------                       -------

99.1                                 Press Release dated April 20, 2006. *


* This exhibit is furnished to, but not filed with, the Commission by inclusion
herein.