SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

                                    FORM 8-K

                                 CURRENT REPORT


     PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934


         Date of Report (Date of earliest event reported): June 11, 2004

                                IPIX CORPORATION
             (Exact name of registrant as specified in its charter)


          DELAWARE                  000-26363                   52-2213841
      (State or other              (Commission                (IRS Employer
jurisdiction of incorporation)     File Number)           Identification Number)


3160 CROW CANYON ROAD, SAN RAMON, CALIFORNIA                       94583
--------------------------------------------------------------------------------
(Address of principal executive offices)                         (Zip Code)


Registrant's telephone number, including area code:            (925) 242-4002
---------------------------------------------------            --------------
                                       N/A
          -------------------------------------------------------------
          (Former name or former address, if changed since last report)






ITEM 4. Changes in Registrant's Certifying Accountant.

     On June 11,  2004,  the Audit  Committee  of the Board of Directors of IPIX
Corporation dismissed PricewaterhouseCoopers LLP as its independent auditors. On
June 11, 2004, the Audit Committee  approved the engagement of Armanino  McKenna
LLP as its  independent  auditors to replace the firm of  PricewaterhouseCoopers
LLP for the Company's fiscal year ending December 31, 2004.

     The reports of  PricewaterhouseCoopers  LLP on the  consolidated  financial
statements  of IPIX  Corporation  for the past two years  contained  no  adverse
opinion or  disclaimer of opinion and were not qualified or modified as to audit
scope or  accounting  principles  except  that the  report  on the  consolidated
financial statements for the year ended December 31, 2003 expressed  substantial
doubt regarding IPIX Corporation's ability to continue as a going concern.

     In connection with the audits of IPIX's consolidated  financial  statements
for each of the past two  fiscal  years  ended  December  31,  2002 and 2003 and
through June 11, 2004 there were no  disagreements  between IPIX Corporation and
its auditors,  PricewaterhouseCoopers LLP on any matter of accounting principles
or practices, consolidated financial statement disclosure, or auditing scope and
procedures, which, if not resolved to the satisfaction of PricewaterhouseCoopers
LLP,  would have caused them to make  reference  thereto in their  report on the
financial statements for such year.

     IPIX Corporation has not previously  consulted with Armanino McKenna LLP on
either the  application  of accounting  principles  to a specified  transaction,
either  completed  or  proposed,  or the type of  audit  opinion  that  might be
rendered on IPIX's consolidated financial statements.

     IPIX  Corporation  has provided  PricewaterhouseCoopers  LLP with a copy of
this  disclosure  and has requested  PricewaterhouseCoopers  LLP to furnish IPIX
with a letter  addressed  to the  Securities  and  Exchange  Commission  stating
whether  PricewaterhouseCoopers  LLP agrees  with the  statements  made above by
IPIX. This letter is attached hereto as Exhibit 16.

Item 7.  Financial Statements, Pro Forma Financial Information and Exhibits

            (a) Not Applicable.

            (b) Not Applicable.

            (c) Exhibits

                  16 Letter of PricewaterhouseCoopers LLP regarding change in
                  certifying accountant.







                                   SIGNATURES

Pursuant  to the  requirements  of the  Securities  Exchange  Act of  1934,  the
Registrant  has duly  caused  this  report  to be  signed  on its  behalf by the
undersigned hereunto duly authorized.

IPIX CORPORATION

Dated:  June 18, 2004               /s/ Paul Farmer
                                    ------------------------
                                    Paul Farmer
                                    Chief Financial Officer











                                  Exhibit Index


Exhibit
Number       Description
-------      ------------
16           Letter of PricewaterhouseCoopers LLP regarding change in certifying
             accountant.