Seres Therapeutics Appoints Paula Cloghessy as Executive Vice President, Chief People Officer

Cloghessy to focus on supporting an inclusive culture and the Company’s continued growth trajectory

Seres Therapeutics, Inc. (Nasdaq: MCRB), a leading microbiome therapeutics company, announced today that Paula Cloghessy, SPHR, SHRM-SCP, has joined Seres as Executive Vice President, Chief People Officer effective February 7, 2022, reporting directly to Eric Shaff, President and Chief Executive Officer.

“Paula joins the Seres leadership team at a pivotal time of growth. Her team-building expertise will be invaluable as we advance SER-109 toward what we expect to be the Company’s first FDA drug approval, while expanding Seres’ pipeline toward additional opportunities in Infection Protection and other diseases that we believe are well suited for our microbiome therapeutic approach,” said Shaff.

Cloghessy brings to Seres more than 20 years of human resources expertise with broad business experience leading human resources organizations in the biotechnology and pharmaceutical industries, including a successful track record of translating organizational objectives into dynamic HR programs and infrastructure. She most recently served as Chief People Officer at Translate Bio, Inc., where she led the talent architecture and people strategy. Throughout her career in biotech, Cloghessy has strived to prioritize the employee environment with an emphasis on curating talent and fostering an adaptive and inclusive culture. Prior to Translate, she served as vice president of human resources at Joule Unlimited Technologies, Inc. She has also held human resources positions at Interleukin Genetics, Inc. and NUCRYST Pharmaceuticals, Inc.

“Behind the incredible science at Seres are the talented and committed professionals dedicated to driving our efforts in Infection Protection forward for patients. I’m excited for the opportunity to help oversee and support the continued growth of the top-flight Seres team,” Cloghessy said. “Seres has a strong, proud culture that supports employee satisfaction, and I look forward to ensuring employees continue to feel supported by expanding our talent development and engagement programs while continuing to add stellar candidates to our workforce.”

Cloghessy holds a B.A. in psychology from the University of Massachusetts Boston and senior human resources certifications including SPHR and SHRM-SCP.

About Seres Therapeutics

Seres Therapeutics, Inc. (Nasdaq: MCRB) is a leading microbiome therapeutics company developing a novel class of multifunctional bacterial consortia that are designed to functionally interact with host cells and tissues to treat disease. Seres’ SER-109 program achieved the first-ever positive pivotal clinical results for a targeted microbiome drug candidate and has obtained Breakthrough Therapy and Orphan Drug designations from the FDA. The SER-109 program is being advanced to reduce the recurrence of C. difficile infection and has potential to become a first-in-class FDA-approved microbiome therapeutic. Seres is evaluating SER-301 in a Phase 1b study in patients with ulcerative colitis and SER-155 in a Phase 1b study in patients receiving allogeneic hematopoietic stem cell transplantation to prevent bloodstream infections and graft-versus-host disease.

For more information, please visit www.serestherapeutics.com.

Forward-Looking Statements

This press release contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. All statements contained in this press release that do not relate to matters of historical fact should be considered forward-looking statements, including Cloghessy’s employment and appointment and the anticipated impact thereof, the potential approval of SER-109 and its status as a first-in-class therapeutic, the potential of microbiome therapeutics to treat and prevent disease, and other statements which are not historical fact.

These forward-looking statements are based on management’s current expectations. These statements are neither promises nor guarantees, but involve known and unknown risks, uncertainties and other important factors that may cause our actual results, performance or achievements to be materially different from any future results, performance or achievements expressed or implied by the forward-looking statements, including, but not limited to, the following: we have incurred significant losses, are not currently profitable and may never become profitable; our need for additional funding; our limited operating history; the impact of the COVID-19 pandemic; our unproven approach to therapeutic intervention; the lengthy, expensive and uncertain process of clinical drug development; our reliance on third parties and collaborators to conduct our clinical trials, manufacture our product candidates and develop and commercialize our product candidates, if approved; and our ability to retain key personnel and to manage our growth. These and other important factors discussed under the caption “Risk Factors” in our Quarterly Report on Form 10-Q filed with the Securities and Exchange Commission, or SEC, on November 10, 2021, and our other reports filed with the SEC could cause actual results to differ materially from those indicated by the forward-looking statements made in this press release. Any such forward-looking statements represent management’s estimates as of the date of this press release. While we may elect to update such forward-looking statements at some point in the future, we disclaim any obligation to do so, even if subsequent events cause our views to change. These forward-looking statements should not be relied upon as representing our views as of any date subsequent to the date of this press release.

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