1 SCHEDULE 14A (Rule 14a-101) Information Required in Proxy Statement Schedule 14A Information Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. ___) Filed by the Registrant [X] Filed by a Party other than the Registrant [ ] Check the appropriate box: [X] Preliminary Proxy Statement [ ] Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) [ ] Definitive Proxy Statement [ ] Definitive Additional Materials [ ] Soliciting Material Under Rule 14a-12 ATRIX LABORATORIES, INC. -------------------------------------------------------------------------------- (Name of Registrant as Specified In Its Charter) -------------------------------------------------------------------------------- (Name of Person(s) Filing proxy statement, if other than the Registrant) Payment of Filing Fee (Check the appropriate box): [X] No fee required. [ ] Fee computed on table below per Exchange Act Rules 14a-6(i)(1) and 0-11. 1) Title of each class of securities to which transaction applies: 2) Aggregate number of securities to which transaction applies: 3) Per unit price or other underlying value of transaction computed pursuant to Exchange Act Rule 0-11 (set forth the amount on which the filing fee is calculated and state how it was determined): 4) Proposed maximum aggregate value of transaction: 5) Total fee paid: [ ] Fee paid previously with preliminary materials. [ ] Check box if any part of the fee is offset as provided by Exchange Act Rule 0-11(a)(2) and identify the filing for which the offsetting fee was paid previously. Identify the previous filing by registration statement number, or the form or schedule and the date of its filing. 1) Amount previously paid: 2) Form, Schedule or Registration Statement No.: 3) Filing Party: 4) Date Filed: 2 [ATRIX LOGO] ATRIX LABORATORIES, INC. Dear Stockholder: On behalf of the Board of Directors, I invite you to attend the Annual Meeting of Stockholders of Atrix Laboratories, Inc. to be held on May 7, 2001 at 10:00 a.m. local time, at The Fort Collins Marriott, 350 East Horsetooth Road, Fort Collins, Colorado. You are urged to vote your proxy even if you currently plan to attend the Annual Meeting. Please remember to sign and date the proxy card, otherwise, it is invalid. Returning your proxy will not prevent you from voting in person but will assure that your vote is counted if you are unable to attend the meeting. Sincerely, /s/ DAVID R. BETHUNE David R. Bethune, Chairman of the Board and Chief Executive Officer April 4, 2001 3 ATRIX LABORATORIES, INC. 2579 MIDPOINT DRIVE FORT COLLINS, COLORADO 80525 (970) 482-5868 --------------------- NOTICE OF ANNUAL MEETING OF STOCKHOLDERS TO BE HELD MAY 7, 2001 --------------------- TO THE STOCKHOLDERS OF ATRIX LABORATORIES, INC.: NOTICE IS HEREBY GIVEN that the Annual Meeting of the Stockholders of Atrix Laboratories, Inc. will be held at The Fort Collins Marriott, 350 East Horsetooth Road, Fort Collins, Colorado 80525 on May 7, 2001 at 10:00 a.m. Fort Collins time, for the following purposes: 1. To elect three directors for three-year terms. 2. To consider and vote on a proposal to amend our 2000 Stock Incentive Plan to increase by 1,000,000 the number of shares of common stock reserved for issuance under the plan. 3. To consider and vote on a proposal to amend our Amended and Restated Certificate of Incorporation to increase the authorized number of shares of capital stock from 30,000,000 to 50,000,000, of which 45,000,000 will be designated common stock and 5,000,000 will be designated preferred stock. 4. To ratify the appointment of Deloitte & Touche LLP as our independent auditors for the fiscal year ending December 31, 2001. 5. To transact such other business as may properly come before the meeting and at any and all postponements, continuations or adjournments thereof. Only stockholders of record at the close of business on March 21, 2001 are entitled to notice of and to vote at the meeting or any postponements, continuations and adjournments thereof. All stockholders, whether or not they expect to attend the meeting in person, are requested to complete, date and sign the enclosed form of proxy and return it promptly in the postage paid, return-addressed envelope provided for that purpose. By returning your proxy promptly, you can help us avoid the expense of follow-up mailings to ensure a quorum so that the meeting can be held. Stockholders who attend the meeting may revoke a prior proxy and vote their proxy in person as set forth in the proxy statement. THE ENCLOSED PROXY IS BEING SOLICITED BY OUR BOARD OF DIRECTORS. OUR BOARD OF DIRECTORS RECOMMENDS THAT YOU VOTE IN FAVOR OF THE PROPOSED ITEMS. YOUR VOTE IS IMPORTANT. By Order of the Board of Directors /s/ DAVID R. BETHUNE David R. Bethune, Chairman of the Board and Chief Executive Officer Fort Collins, Colorado Dated: April 4, 2001 4 ATRIX LABORATORIES, INC. 2579 MIDPOINT DRIVE FORT COLLINS, COLORADO 80525 (970) 482-5868 --------------------- PROXY STATEMENT ANNUAL MEETING OF STOCKHOLDERS TO BE HELD MAY 7, 2001 --------------------- INTRODUCTION This proxy statement is furnished in connection with the solicitation of proxies by and on behalf of the board of directors of Atrix Laboratories, Inc., a Delaware corporation, for use at our Annual Meeting of Stockholders to be held at The Fort Collins Marriott, 350 East Horsetooth Road, Fort Collins, Colorado, on May 7, 2001 at 10:00 a.m. Fort Collins time and at any postponements, continuations or adjournments thereof. This proxy statement, the accompanying form of proxy and the notice of annual meeting will be first mailed or given to our stockholders on or about April 4, 2001. All shares of our $.001 par value common stock, represented by properly executed Proxies received in time for the meeting will be voted at the meeting in accordance with the instructions marked thereon or otherwise as provided therein, unless such Proxies have previously been revoked. Unless instructions to the contrary are marked, or if no instructions are specified, shares represented by proxies will be voted for the proposals set forth on the proxy, and in the discretion of the persons named as proxies, on such other matters as may properly come before the meeting. You may revoke your proxy at any time prior to its exercise by submitting another proxy bearing a later date, giving written notice of revocation to us at the address indicated above or by voting in person at the meeting. Any notice of revocation sent to us must include the stockholder's name and must be received prior to the meeting to be effective. VOTING Only holders of record of shares at the close of business on March 21, 2001, or the record date, will be entitled to receive notice of and to vote at the meeting. On the record date there were shares outstanding, each of which will be entitled to one vote on each matter properly submitted for vote to the stockholders at the meeting. The presence, in person or by proxy, of holders of a majority of shares entitled to vote at the meeting constitutes a quorum for the transaction of business at the meeting. Our transfer agent will tabulate votes cast by proxy by an automated system. Votes cast by proxy or in person at the meeting will be counted by the persons appointed by us to act as election inspectors for the meeting. Abstentions, broker non-votes, which are explained below, and shares as to which authority to vote on any proposal is withheld, are each included in the determination of the number of shares present and voting at the meeting for purposes of obtaining a quorum. Each will be tabulated separately. While there is no definitive statutory or case law authority in Delaware as to the proper treatment of abstentions and broker non-votes in all circumstances, we believe that both abstentions and broker non-votes should be counted for purposes of determining whether a quorum is present at the annual meeting. In the absence of controlling precedent to the contrary, we intend to treat abstentions and broker non-votes in the following manner. A broker "non-vote" occurs when a nominee holding shares for a beneficial owner does not vote on a particular proposal because the nominee does not have the discretionary voting power with respect to that item and has not received instructions from the beneficial owner. Broker "non-votes" and shares as to which proxy authority has been withheld with respect to any matter are not deemed to be entitled to vote for purposes of determining whether stockholder approval of that matter has been obtained. As a result, broker "non-votes" are not included in the tabulation of the voting results on the election of directors or issues requiring the approval of a majority of the shares of common stock 5 present and entitled to vote and, therefore, do not have the effect of votes in opposition for such proposals. With respect to Proposal 1 requiring a plurality vote and Proposals 2 and 4 requiring the affirmative vote of a majority of the common stock, present and entitled to vote, broker "non-votes have no effect. However, with respect to Proposal 3 which requires the affirmative vote of a majority of the outstanding shares of our common stock, broker "non-votes" and shares as to which proxy authority has been withheld have the effect of a vote against Proposal 3. Because abstentions will be included in tabulations of the shares of common stock entitled to vote for purposes of determining whether a proposal has been approved, abstentions have the same effect as negative votes on Proposals 2, 3 and 4. PROPOSAL NO. 1 ELECTION OF DIRECTORS Our Certificate of Incorporation provides for a board of directors made up of three classes. The members of each class serve three-year staggered terms with one class to be elected at each annual meeting. As provided in our Bylaws, the board of directors has currently set the total number of directors at ten, with four directors in Class A, three directors in Class B and three directors in Class C. The current terms of the Class C and Class A directors expire at our Annual Meeting of Stockholders for the years ended 2001 and 2002, respectively. The current term of the Class B directors expires at the meeting for the year ended 2000. Dr. Jere E. Goyan resigned his position as a Class B Director in April, 2000. The Board appointed Dr. Nicolas G. Bazan to replace Dr. Goyan for a one-year term expiring at the meeting and until his successor is elected and qualified. The Board has nominated Mr. David R. Bethune, Dr. Richard L. Jackson and Dr. Nicolas Bazan for election as Class B directors to serve for a three-year term expiring at the Annual Meeting of Stockholders for the year ended 2003 and until their successors are elected and qualified. Each director nominee is currently a Class B director. Each of the nominees has consented to be a nominee and to serve as a director if elected. We intend that shares represented by properly executed proxies will be voted for the election of the nominees except where authority to so vote is withheld. Our board of directors has no reason to believe that any of the director nominees will be unable to serve as directors or will become unavailable for any reason. If, at the time of the meeting, any of the director nominees becomes unavailable for any reason, the persons entitled to vote the proxy will vote for such substituted nominee or nominees, if any, as such persons determine in their discretion. Information is set forth below regarding the director nominees and the directors who will continue in office after the meeting, including the name and age of each director and nominee, his principal occupation and business experience during the past five years and the commencement of his term as our director. OUR BOARD OF DIRECTORS RECOMMENDS THAT THE STOCKHOLDERS VOTE FOR THE PROPOSAL TO ELECT MR. DAVID R. BETHUNE, DR. RICHARD I. JACKSON AND DR. NICOLAS BAZAN FOR ELECTION AS CLASS B DIRECTORS. 2 6 NOMINEES FOR ELECTION PRINCIPAL OCCUPATION OR EMPLOYMENT DURING DIRECTOR NAME AND AGE PAST FIVE YEARS; OTHER DIRECTORSHIPS SINCE ------------ ----------------------------------------- -------- David R. Bethune(1) Chairman and Chief Executive Officer since August 1999. 1995 (60) President and Chief Operating Officer of IVAX Corporation, a pharmaceutical holding company, from 1997 to 1998. Consultant to the pharmaceutical industry from 1996 to 1997. President and Chief Executive Officer of Aesgen, Inc., a pharmaceutical company, from 1995 to 1996. Group Vice President of American Cyanamid Company, a health care business, from 1992 to 1995. Mr. Bethune also serves as a director of Female Health Co. Mr. Bethune received a Bachelors degree in Business from Lenoir Rhyne College and Executive Management degree from Columbia University Graduate School. Dr. Richard Jackson(1) Senior Vice President of Research and Development since 1999 (62) November 1998. Senior Vice President of Discovery Research at Wyeth-Ayerst, American Home Products from 1992 to June 1998. Dr. Jackson received his B.S. in Chemistry and his Ph.D. degree in Microbiology from the University of Illinois, Urbana, Illinois. Dr. Nicolas Bazan(2) Professor at Louisiana State University Medical Center and 2000 (58) Neuroscience Center of Excellence in the areas of Ophthalmology, Biochemistry, Molecular Biology, and Neurology; Director, Neuroscience Training Program. Dr. Bazan sits on the Scientific Advisory Board of Centaur in Sunnyvale, California, and is the founder and Chairman of the Board of St. Charles Pharmaceuticals in New Orleans, Louisiana. Dr. Bazan received his Bachelor's degree from Colegio Belgrano, Argentina, his M.D. from U. Tucuman, Argentina, and his Ph.D. from the Medical School at U. Tucuman. --------------- (1) Member of the Executive Committee (2) Added as Class B director in November 2000 DIRECTORS WHOSE TERM OF OFFICE WILL CONTINUE AFTER THE MEETING PRINCIPAL OCCUPATION OR EMPLOYMENT DURING DIRECTOR NAME AND AGE PAST FIVE YEARS; OTHER DIRECTORSHIPS SINCE ------------ ----------------------------------------- -------- John E. Urheim(1)* (60) Principal, Urheim Consultants since August 1998. 1993 Vice Chairman and Chief Executive Officer from June 1993 to August 1999. Mr. Urheim received his Masters degree in Economics from the University of Iowa. Sander A. Flaum(1)(2)* (64) Chief Executive Officer of Robert A. Becker, Inc. 1999 Euro RSCG (a member of the Euro RSCG Healthcare Global Network) since 1998. Mr. Flaum is also adjunct professor at The Fordham University Graduate School of Business in New York City and a member of the editorial advisory board of Pharmaceutical Executive. He serves on the boards of Fischer College of Business at The Ohio State University, Fordham Graduate School of Business, Hollins Communications Research Institute and Neopharm Corporation. 3 7 PRINCIPAL OCCUPATION OR EMPLOYMENT DURING DIRECTOR NAME AND AGE PAST FIVE YEARS; OTHER DIRECTORSHIPS SINCE ------------ ----------------------------------------- -------- Dr. D. Walter Cohen(1)* (74) Chancellor-Emeritas of MCP Hahnemann University's 1992 School of Medicine since 1998, chancellor of MCP Hahnemann University's School of Medicine from 1993 to 1998 and President of MCP Hahnemann University's School of Medicine from 1986 to 1993. Since 1950, Dr. Cohen has had a dental practice specializing in periodontics. Dr. Cohen also serves as a director of Crusader Bank of Philadelphia. Dr. Cohen received his DDS from the University of Pennsylvania School of Dentistry and served as its Dean from 1972 to 1983. C. Rodney O'Connor(2)** (68) Chairman and Chief Executive Officer of Cameron 1987 Associates, Inc., a financial services firm, since 1976. Mr. O'Connor also serves on the boards of Streicher Mobile Fueling, Inc., Fundamental Management Corporation and Morgan Holdings, Inc. Mr. O'Connor received a Bachelor of Arts Degree from Wesleyan University and a Masters Degree in Finance from the Wharton School of Finance. Mr. H. Stuart Campbell(2)** Owner and Vice-President of Highland Packaging 1995 (71) Labs, Inc., a specialty packaging company for the pharmaceutical industry, since 1983. Mr. Campbell also serves as a director for Biomatrix, Inc. and Mesa Laboratories, Inc. Campbell received a Bachelor of Science degree from Cornell University. --------------- (1) Member of the Compensation Committee (2) Member of the Audit Committee * Class A Director ** Class C Director BOARD MEETINGS During 2000 the board of directors met six times and acted by unanimous written consent four times. No director attended fewer than 75% of the aggregate of (i) the total number of meetings of the board of directors during 2000; and (ii) the total number of meetings held by all committees of the board of directors on which he served during 2000. COMMITTEES OF THE BOARD Executive Committee. Our board of directors has an executive committee and during 2000 its members were Mr. Bethune, chairman of the executive committee, and Drs. Southard and Jackson. Dr. Southard resigned his position from our board of directors and from the executive committee in November 2000. The executive committee has the authority to conduct our business and affairs, except where action of the entire board of directors is specified by statute. Our Executive Committee did not meet in 2000. Audit Committee. Our board has an audit committee and during 2000 our members were Mr. O'Connor, Mr. Flaum and Mr. Campbell. Messrs. O'Connor, Flaum and Campbell are "independent" directors as defined in Rule 4200(a)(14) of the National Association of Securities Dealers listing standards. Mr. O'Connor was chairman of the audit committee until November 2000, at which time Mr. Campbell was named chairman of the committee. The audit committee's duties include the following: (i) making recommendations to our board of directors as to the selection of our independent auditors; 4 8 (ii) reviewing the results of our annual audit with the independent auditors and appropriate management representatives; (iii) reviewing with the independent auditors such major accounting policies as are deemed appropriate for review by the audit committee; and (iv) reporting to our board of directors at each meeting of the full board following a meeting of the audit committee concerning its activities. Our audit committee met one time during 2000. Mr. Flaum did not attend the meeting. Compensation Committee. Our Board has a compensation committee and during 2000 its members were Mr. Campbell, Chairman of the compensation committee, Mr. Flaum and Dr. Cohen. In November 2000, Mr. Flaum became the Chairman, and Mr. Urheim replaced Mr. Campbell. The compensation committee performs the following duties: (i) considering and making recommendations to our Board with respect to our overall compensation policies; (ii) approving the compensation payable to all officers; (iii) reviewing proposed compensation of executives as provided in our executive compensation plan; (iv) advising management on all other executive compensation matters as requested; (v) construing and interpreting our Amended and Restated Stock Option Plan, or our Stock Option Plan, and our 2000 Incentive Stock Option Plan, or our Incentive Plan, and, subject to the express provisions of our Stock Option Plan and Incentive Plan, determining the persons to whom options are granted, the number of shares subject to options, when options shall be granted, the exercise price of shares subject to options, the time during which options shall be exercisable and the duration of the exercise period and other terms and provisions thereof; and (vi) reporting to our Board as and when appropriate with respect to all of the foregoing. In November 2000, the Board established an Option Committee, the sole member of which is Dr. David R. Bethune, which is generally responsible for determining individuals who are entitled to option grants, the number of options granted and the terms and conditions of the options. Our compensation committee met two times during 2000. All members were present. Nominating Committee. Our Board established a nominating committee in March 2001. The nominating committee monitors the size and composition of the Board and considers and makes recommendations with respect to the nomination and election of directors. The nominating committee will also consider nominees recommended by stockholders. Recommendations for our Annual Meeting of Stockholders to be held in 2002 must be submitted in writing to our Corporate Secretary at 2579 Midpoint Drive, Fort Collins, Colorado 80525. Such recommendations must include the name, address and principal business occupation of the candidate for the last five years and must be received by the Corporate Secretary on or before November 30, 2001. EXECUTIVE OFFICERS Information is set forth below regarding our executive officers, including their age, principal occupation during the last five years and the date each first became an executive officer. Our executive officers serve in such capacity at the pleasure of our board of directors. EXECUTIVE OFFICER NAME AGE PRESENT EXECUTIVE OFFICE OF THE COMPANY SINCE ---- --- ------------------------ -------------------- David R. Bethune 60 Chairman and Chief Executive Officer since August 1999 1999. President and Chief Operating Officer of IVAX Corporation from 1997 to 1998. Consultant to the pharmaceutical industry from 1996 to 1997. President and Chief Executive Officer of Aesgen, Inc from 1995 to 1996. Dr. Richard Jackson 62 Senior Vice President of Research and Development 1998 since November 1998 and Senior Vice President of Discovery Research of Wyeth-Ayerst, American Home Products from 1993 to June 1998. 5 9 EXECUTIVE OFFICER NAME AGE PRESENT EXECUTIVE OFFICE OF THE COMPANY SINCE ---- --- ------------------------ -------------------- Dr. Richard L. Dunn 60 Senior Vice President, Drug Delivery Research since 1987 1998; Vice President, Drug Delivery Research from 1992-1998 and Vice President, Research and Development from 1987 to 1992. Dr. Charles P. Cox 48 Vice President, New Business Development since 1992 January 1996 and Vice President, Product Development from September 1992 to January 1996. Brian G. Richmond 49 Vice President, Finance since December 1997, 1997 Assistant Secretary since January 1997, Corporate Controller from January 1997 to November 1997 and Accounting Manager from 1991 to 1996. Dr. J. Steven Garrett 56 Vice President, Clinical Research since April 1995. 1995 Professor of Periodontics at Loma Linda University from 1986 to 1995 and in private practice specializing in periodontics since 1978. Michael R. Duncan 38 Vice President, Manufacturing since October 1995. 1995 Director of Production Operations and Packaging Manager for Geneva Pharmaceuticals, Inc. from October 1991 to October 1995. David W. Osborne 40 Vice President, Pharmaceutical Development since 1998 November 1998. Vice President of Research and Development for ViroTex Corporation from June 1993 to November 1998. Elaine M. Gazdeck 50 Vice President, Regulatory Affairs/Quality 1996 Assurance since June 1996, Director, Regulatory Affairs from May 1994 to May 1996 and Manager, Regulatory Affairs from May 1990 to April 1994. Sean F. Moriarty 36 Vice President, Licensing and Counsel since October 2000 2000. Director of Business Development for Geneva Pharmaceuticals from September 1998 to October 2000. Attorney with the law firm of Isaacson, Rosenbaum, Woods & Levy, P.C. from June 1996 to September 1998. Magnus Pelles 54 Vice President Sales & Marketing, European 2000 Operations since January 2000. Managing Director and Chief Executive Officer for Germany, Austria and Switzerland for Biora AB from 1995 to January 2000. Officers serve at the discretion of our board of directors and are elected at the first meeting of the board of directors after each annual meeting of stockholders. There are no family relationships among any of our directors or executive officers. 6 10 PROPOSAL NO. 2 APPROVAL OF THE AMENDMENT TO THE 2000 STOCK INCENTIVE PLAN Our stockholders are being asked to vote on the proposed amendment to our Incentive Plan amendment to increase by 1,000,000 the number of shares authorized for issuance under the plan to 2,750,000. The Incentive Plan amendment currently provides for the issuance of stock options and restricted stock covering up to 1,750,000 shares plus any shares awarded under our Stock Option Plan which are cancelled, expired or are forfeited to us. As of the record date, options to purchase an aggregate of shares and shares of restricted stock were outstanding, and options to purchase shares or shares of restricted stock totaling shares were available for future grant. Our Board has concluded that the proposed amendment is in the best interests of us and our stockholders. The amendment to our Incentive Plan to increase the number of shares that may be issued thereunder will enable us to grant options and restricted stock as needed to attract and retain talented employees. Our Board believes that our long-term success depends upon our ability to attract and retain highly qualified individuals who, by virtue of their ability and qualifications, make important contributions to us. Our Incentive Plan is intended to enhance our ability to provide individuals with awards and incentives commensurate with their contributions and is competitive with those offered by other employers. The stock options and restricted stock granted under this Plan will increase stockholder value by further aligning the interests of these individuals with the interests of our stockholders by providing our employees an opportunity to benefit from stock price appreciation that generally accompanies improved financial performance. Because of our continuing efforts to conserve cash and pursue a conservative fiscal policy, stock and options have constituted and will continue to constitute an important and significant component of the compensation offered to our employees. Especially in the highly competitive biotechnology industries, the ability to attract and retain highly qualified employees is essential to our success. The grant of stock options and restricted stock in these industries is often the primary consideration of individual employees in making employment decisions, both at the time of initial employment and later when they consider possible employment alternatives. It is essential that we have a stock incentive plan which provides a sufficient number of option available for grant. A general description of the principal terms of our Incentive Plan is set forth below; however, the summary does not purport to be a complete description of all of the provisions of our Incentive Plan and is qualified in its entirety by reference to Incentive Plan. Copies of the Incentive Plan may be obtained upon request to our principal executive offices. The affirmative vote of a majority of the shares present in person or by proxy at our meeting and entitled to vote is required for approval of the amendment to our Incentive Plan. GENERAL DESCRIPTION Our Incentive Plan was approved by our Board in March 2000 and by our stockholders in May 2000. The purposes of our Incentive Plan are to give our employees, directors and consultants an incentive, through ownership of our common stock, to continue in service to us, and to help us compete effectively with other enterprises for the services of qualified individuals. Our Incentive Plan permits the grant of "incentive stock options," or ISOs within the meaning of Section 422 of the Internal Revenue Code, or the Code, only to our employees or any parent or subsidiary corporation ours. Non-qualified stock options and restricted stock may be granted to employees, directors and consultants. Our Incentive Plan provides for the grant of options, including ISOs and non-qualified stock options, or awards, with an exercise privilege at a fixed price related to the common stock and/or the passage of time, the occurrence of one or more events or the satisfaction of performance criteria or other conditions. Under our Incentive Plan, awards may be granted to such employees, directors or consultants who are residing in foreign jurisdictions as the administrator may determine from time to time. The 7 11 Incentive Plan is not a qualifying deferred compensation plan under Section 401(a) of the Code and is not subject to the provisions of the Employee Retirement Income Security Act of 1974, as amended, or ERISA. ADMINISTRATION Our Incentive Plan is administered, with respect to grants to directors, officers, consultants, and other employees, by the administrator of our Incentive Plan, defined as our Board or a committee designated by our Board. Our committee is constituted in such a manner as to satisfy applicable laws, including Rule 16b-3 promulgated under the Securities Exchange Act of 1934, as amended. With respect to awards subject to Code Section 162(m), the committee will be comprised solely of two or more "outside directors" as defined under Code Section 162(m) and applicable tax regulations. For grants of awards to individuals not subject to Rule 16b-3 and Code Section 162(m), our Board may authorize one or more officers to grant such awards. SHARES RESERVED Our Incentive Plan provides for the issuance of stock options and restricted stock covering up to 1,750,000 shares plus any shares awarded under our Stock Option Plan which are forfeited to us. The Incentive Plan was intended to replace the Stock Option Plan. Options that are outstanding under our Stock Option Plan will remain outstanding under such plan. Option grants made after our stockholders approved our Incentive Plan in May 2000 have been and will continue to be made under our Incentive Plan. However, to the extent that options granted under our Stock Option Plan are forfeited, expired or are cancelled without delivery of shares or which otherwise result in the forfeiture of shares back to us, there is an automatic corresponding increase in the shares authorized for issuance under our Incentive Plan. CODE SECTION 162(M) LIMITATIONS Our Incentive Plan limits the number of options, which may be awarded to an employee in any fiscal year to 250,000 shares. However, in connection with his or her initial commencement of services with us, a participant in our Incentive Plan may be granted stock options for up to an additional 100,000 shares, which do not count against the limit set forth in the previous statement. The limitations ensure that any options granted under our Incentive Plan qualify as "performance-based compensation" under Section 162(m) of the Code. Under Code Section 162(m) no deduction is allowed in any taxable year for compensation in excess of $1 million paid to our chief executive officer and each of our four most highly paid other executive officers who are serving in such capacities as of the last day of such taxable year. An exception to this rule applies to compensation that is paid pursuant to a stock incentive plan approved by our stockholders and that specifies, among other things, the maximum number of shares with respect to which options may be granted to eligible employees under such plan during a specified period. Compensation paid pursuant to options granted under such a plan and with an exercise price equal to the fair market value of our common stock on the date of grant is deemed to be inherently performance-based, since such awards provide value to employees only if the stock price appreciates. If our Incentive Plan did not contain the Code Section 162(m) share limits with respect to which options may be granted to eligible employees under such plan during a specified period, any compensation expense associated with the options granted under our Incentive Plan in excess of the shares currently available for issuance (together with all other non-performance based compensation) in excess of $1 million for any of our five highest paid officers would not be deductible under the Code. AMENDMENT AND TERMINATION Our Board may at any time amend, suspend or terminate our Incentive Plan. To the extent necessary to comply with applicable provisions of federal securities laws, state corporate and securities laws, the Code, the rules of any applicable stock exchange or national market system and the rules of any foreign 8 12 jurisdiction applicable to awards granted to residents therein, we will obtain stockholder approval of any amendment to our Incentive Plan in such a manner and to such a degree as required. Our Incentive Plan will terminate in March 2010 unless previously terminated by our Board. OTHER TERMS Our Incentive Plan authorizes the administrator to select the employees, directors and consultants of ours to whom awards may be granted. The Plan also authorizes the administrator and to determine the terms and conditions of any award; however, the term of an award may not be for more than 10 years (or 5 years in the case of ISOs granted to any grantee who owns stock representing more than 10% of the combined voting power of ours or any parent or subsidiary corporation of ours). Our Incentive Plan authorizes the administrator to grant ISOs at an exercise price of not less than 100% (or 110% in the case of ISOs granted to any grantee who owns stock representing more than 10% of the combined voting power of ours or any parent or subsidiary corporation of ours) of the fair market value of the shares on the date the option is granted. Non-qualified stock options may be granted at an exercise price of not less than 85% of the fair market value of the shares on the date the option is granted. The exercise price of awards intended to qualify as performance-based compensation for purposes of Code Section 162(m) may not be less than 100% of the fair market value. The exercise price is generally payable in cash or, in certain circumstances, with a promissory note, with such documentation as the administrator and the broker, if applicable, requires us to effect an exercise of an Award and delivery to us of the sale or loan proceeds required to pay the exercise price, or with shares. The aggregate fair market value of the shares with respect to any ISOs that are exercisable for the first time by an eligible employee in any calendar year may not exceed $100,000. Awards may be granted subject to vesting schedules and restrictions on transfer and repurchase or forfeiture rights in favor of us as specified in agreements issued under our Incentive Plan. The administrator has the authority to accelerate the vesting schedule of awards so that they become fully vested, exercisable and released from any restrictions on transfer and repurchase or forfeiture rights in the event of a change in control, corporate transaction or related entity disposition, all as defined in our Incentive Plan. Effective upon the consummation of a corporate transaction, all outstanding awards under our Incentive Plan will terminate unless assumed by the successor company or its parent including affirmation of the awards by us if we are the surviving entity in the transaction. Our Incentive Plan also permits the administrator to include a provision whereby the grantee may elect at any time while an employee, director or consultant to exercise any part or all of the award prior to full vesting of the award. Under our Incentive Plan, ISOs may not be sold, pledged, assigned, hypothecated, transferred or disposed of in any manner other than by will or by the laws of descent or distribution and may be exercised during the lifetime of the grantee only by the grantee. However, our Incentive Plan permits the designation of beneficiaries by holders of ISOs. Other awards are transferable to the grantee's immediate family to the extent provided in the award agreement or in the manner and to the extent permitted by the administrator. Under our Incentive Plan, the administrator may establish one or more programs under our Incentive Plan to permit selected grantees the opportunity to elect to defer receipt of consideration payable under an award. The administrator also may establish under our Incentive Plan separate programs for the grant of particular forms of awards to one or more classes of grantees. CERTAIN FEDERAL TAX CONSEQUENCES The grant of a non-qualified stock option under our Incentive Plan will not result in any federal income tax consequences to the optionee or to us. Upon exercise of a non-qualified stock option, the optionee is subject to income taxes at the rate applicable to ordinary compensation income on the difference between the option exercise price and the fair market value of the shares on the date of exercise. This income is subject to withholding for federal income and employment tax purposes. We are is entitled to an income tax deduction in the amount of the income recognized by the optionee, subject to 9 13 possible limitations imposed by Section 162(m) of the Code. Any gain or loss on the optionee's subsequent disposition of the shares will receive long-term or short-term capital gain or loss treatment, depending on whether the shares are held for more than one year following exercise. We do not receive a tax deduction for any such gain. The grant of an ISO under our Incentive Plan will not result in any federal income tax consequences to the optionee or to us. An optionee recognizes no federal taxable income upon exercising an ISO (subject to the alternative minimum tax rules discussed below), and we receive no deduction at the time of exercise. The tax consequences of a disposition of stock acquired upon exercise of an ISO depends upon how long the optionee has held the shares. If the optionee does not dispose of the shares within two years after the ISO was granted, nor within one year after the ISO was exercised, the optionee will recognize a long-term capital gain (or loss) equal to the difference between the sale price of the shares and the exercise price. We are not entitled to any deduction under these circumstances. If the optionee fails to satisfy either of the foregoing holding periods, he or she must recognize ordinary income in the year of the disposition (referred to as a disqualifying disposition). The amount of such ordinary income generally is the lesser of (i) the difference between the amount realized on the disposition and the exercise price, or (ii) the difference between the fair market value of the stock on the exercise date and the exercise price. Any gain in excess of the amount taxed as ordinary income will be treated as a long-term or short-term capital gain, depending on whether the stock was held for more than one year. We are entitled to a deduction equal to the amount of ordinary income recognized by the optionee in the year of the disqualifying disposition. The "spread" under an ISO, i.e., the difference between the fair market value of the shares at exercise and the exercise price, is classified as an item of adjustment in the year of exercise for purposes of the alternative minimum tax. The grant of restricted stock will subject the recipient to ordinary compensation income on the difference between the amount paid for such stock and the fair market value of the shares on the date that the restrictions lapse. This income is subject to withholding for federal income and employment tax purposes. We are entitled to an income tax deduction in the amount of the ordinary income recognized by the recipient, subject to possible limitations imposed by Section 162(m) of the Code. Any gain or loss on the recipient's subsequent disposition of the shares will receive long-term or short-term capital gain or loss treatment depending on whether the shares are held for more than one year and depending on how long the stock has been held since the restrictions lapsed. We do not receive a tax deduction for any such gain. Recipients of restricted stock may make an election under Section 83(b) of the Code to recognize as ordinary compensation income in the year that such restricted stock is granted the amount equal to the spread between the amount paid for such stock and the fair market value on the date of the issuance of the stock. If such an election is made, the recipient recognizes no further amounts of compensation income upon the lapse of any restrictions and any gain or loss on subsequent disposition will be long-term or short-term capital gain to the recipient. An election under Section 83(b) must be made within 30 days from the time the restricted stock is issued. THE FOREGOING IS ONLY A SUMMARY OF THE CURRENT EFFECT OF FEDERAL INCOME TAXATION UPON THE GRANTEE AND US WITH RESPECT TO THE SHARES PURCHASED UNDER OUR INCENTIVE PLAN. YOU SHOULD REFER TO THE APPLICABLE PROVISIONS OF THE CODE. IN ADDITION, THE SUMMARY DOES NOT DISCUSS THE TAX CONSEQUENCES OF A GRANTEE'S DEATH OR THE INCOME TAX LAWS OF ANY MUNICIPALITY, STATE OR FOREIGN COUNTRY TO WHICH THE GRANTEE MAY BE SUBJECT. PLAN BENEFITS The grant of stock options and shares of restricted stock to executive officers is subject to the discretion of our compensation committee and our board of directors. The following table sets forth the number of stock options and shares of restricted stock granted to our Chief Executive Officer and our other four most highly compensated executive officers whose total annual compensation exceeded $100,000 10 14 during 2000 (referred to as named executive officers), all current executive officers as a group, all current directors who are not executive officers as a group and all employees, including all current officers who are not executive officers as a group and the exercise prices for such options and shares. The closing price of our shares of common stock on the Nasdaq National Market as of the record date was $ . As of the date hereof, our compensation committee and our Board has not determined future awards that may be made under our Incentive Plan. Accordingly, future benefits or amounts received are not determinable. OUR BOARD OF DIRECTORS RECOMMENDS A VOTE FOR APPROVAL OF THE AMENDMENT TO THE 2000 STOCK INCENTIVE PLAN. PROPOSAL NO. 3 APPROVAL OF AMENDMENT TO CERTIFICATE OF INCORPORATION Our stockholders are being asked to vote on the proposed amendment to our certificate of incorporation to increase from 30,000,000 to 50,000,000 the number of shares of our authorized stock, 45,000,000 of which will be designated common stock and 5,000,000 of which will be designated preferred stock. Our certificate of incorporation currently authorizes the issuance of 25,000,000 shares of common stock. In February 2001, our board of directors approved an increase in the authorized number of shares of our common stock to 45,000,000 shares, subject to stockholder approval of the amendment. As of the record date, there were approximately issued and outstanding shares of our common stock and approximately 554,834 additional shares reserved for future issuance under our stock option plans. Under our employee stock purchase plan, there were approximately 282,663 shares available for grant of purchase. There were also approximately 1,000,000 shares of common stock issued for issuance upon the exercise of outstanding warrants and 667,500 shares reserved for issuance upon the conversion of 12,015 shares of Series A Convertible Exchangeable Preferred Stock issued and outstanding. Based upon the foregoing number of outstanding and reserved shares of common stock, we currently have approximately million shares remaining available for other purposes. Our certificate of incorporation currently authorizes the issuances of 5,000,000 shares of preferred stock, 200,000 shares of which have been designated Series A Preferred Stock and 20,000 of which have been designated Series A Convertible Exchangeable Preferred Stock . As of the record date shares of the Series A Preferred Stock have been reserved for issuance under our stockholder rights plan and 12,015 shares of our Series A Convertible Exchangeable Preferred Stock were outstanding. Accordingly, we currently have approximately shares of preferred stock remaining available for other purposes. In 2000, we continued to utilize the issuance of equity to establish collaborative arrangements with large pharmaceutical and biotechnology companies and to acquire technologies and products. Our board of directors considers the proposed authorization of an additional 25,000,000 shares of common stock desirable because it would provide us with the ability to take advantage of future opportunities for the issuance of equity in connection with financings, possible future acquisitions of companies, products and technologies, other programs to facilitate expansion and growth and for other general corporate purposes, including stock dividends, stock splits and employee benefit plans, without the delay and expense incident to the holding of a special meeting of stockholders to consider any specific issuance. Such additional shares could also be issued in a public offering or privately placed to raise capital for various purposes. Authorized but unissued shares may be issued at such time or times, to such person or persons and for such consideration as our board of directors determines to be in the best interests of us. In February 2001, we filed a Registration Statement on Form S-3 for the issuance and sale from time to time of up to 4,000,000 shares. We intend to issue and sale additional shares of our common stock to raise equity capital when deemed advisable by our board of directors, considering the market price of the shares of our common stock and our capital resources. We may also issue additional shares of our common stock as permitted or required under our employee benefit plans and under outstanding options, 11 15 warrants and other securities convertible into common stock. Our board of directors has no other immediate plans, understanding, agreements or commitments to issue additional common stock or any shares of preferred stock for any purposes. No additional action or authorization by our stockholders would be necessary prior to the issuance of such additional shares of common or preferred stock, unless required by applicable law or the rules of any stock exchange or national securities association trading system on which our common stock is then listed or quoted. We reserve the right to seek a further increase in authorized shares from time to time in the future as considered appropriate by our board of directors. Under our certificate of incorporation, our stockholders do not have preemptive rights with respect to common or preferred stock. Thus, should our board of directors elect to issue additional shares of common stock, existing stockholders would not have any preferential rights to purchase such shares. In addition, if our board of directors elects to issue additional shares of common or preferred stock, such issuance could have a dilutive effect on the earnings per share, voting power and shareholdings of current stockholders. The proposed amendment to increase the authorized number of shares of stock could, under certain circumstances, have an anti-takeover effect, although this is not the intention of this proposal. For example, in the event of a hostile attempt to take over control of Atrix, we may endeavor to impede the attempt by issuing shares of common or preferred stock, thereby diluting the voting power of the other outstanding shares and increasing the potential costs to acquire control of Atrix. The amendment therefore may have the effect of discouraging unsolicited takeover attempts, thereby potentially limiting the opportunity for our stockholders to dispose of their shares at the higher price generally available in takeover attempts or that may be available under a merger proposal. The proposed amendment may have the effect of permitting our current management, including the current board of directors, to retain its position, and place it in a better position to resist changes that stockholders may wish to make if they are dissatisfied with the conduct of our business. However, our board of directors is not aware of any attempt to take control of Atrix, and our board of directors has not presented this proposal with the intent that it be utilized as a type of anti-takeover device. If the proposed amendment is adopted, it will become effective upon filing of a certificate of amendment to our certificate of incorporation with the Delaware Secretary of State. If our stockholders approve the proposed amendment to our certificate of incorporation, however, our board of directors retains discretion under Delaware law not to implement the proposed amendment. If our board of directors exercised such discretion, the number of authorized shares would remain at current levels. The affirmative vote of the holders of a majority of outstanding shares of our common stock is required to approve the amendment to our certificate of incorporation. OUR BOARD OF DIRECTORS RECOMMENDS THAT STOCKHOLDERS VOTE FOR THE PROPOSAL OF THE AMENDMENT TO OUR CERTIFICATE OF INCORPORATION TO INCREASE THE NUMBER OF AUTHORIZED SHARES OF STOCK FROM 30,000,000 TO 50,000,000. 12 16 EXECUTIVE COMPENSATION The following table sets forth information concerning compensation paid by us for each of the last three fiscal years to our Chief Executive Officer and the named executive officers. SUMMARY COMPENSATION TABLE LONG-TERM COMPENSATIONS ------------- AWARDS ANNUAL ------------- COMPENSATION SECURITIES -------------------- UNDERLYING ALL OTHER NAME AND PRINCIPAL POSITION YEAR SALARY($) BONUS($) OPTIONS(#) COMPENSATION($) --------------------------- ---- --------- -------- ------------- --------------- Mr. David R. Bethune, 2000 $255,000 $ -0- 260,000 $ 101,459(2) Chairman and CEO 1999 94,808 -0- 309,380(1) Dr. Richard L. Jackson 2000 $250,000 $ -0- 150,000 $ 22,368(7) Director, Senior Vice President, 1999 250,000 -0- -0- -0- Research and Development 1998 41,667 -0- 100,000 -0- Dr. J. Steven Garrett 2000 $190,000 $ -0- 100,000 $ 5,458(3) Vice President, Clinical Research 1999 190,000 $ -0- 9,000 4,984(3) 1998 178,000 40,000(4) 7,500 4,620(3) Dr. Charles P. Cox, 2000 $155,000 $ -0- 86,000 $ 15,846(5) Vice President, New Business Development 1999 155,000 -0- 7,500 5,000(3) 1998 145,000 30,000(4) 7,500 4,313(3) Dr. Richard L. Dunn, 2000 $152,000 $ -0- 69,000 $ 14,516(6) Senior Vice President, Drug Delivery Research 1999 152,000 -0- 6,500 4,567(3) 1998 142,000 30,000(4) 7,500 4,251(3) --------------- (1) Upon becoming CEO on August 10, 1999, the board of directors provided Mr. Bethune the right to purchase up to 50,000 shares of common stock at the market price on the date of purchase. Upon purchase, we agreed to match the number of shares acquired for no additional consideration. During 2000, 10,000 shares were acquired and an additional 10,000 were issued to match these corresponding stock purchases. We recognized $309,380 of compensation expense related to this arrangement. This restricted stock award cannot be traded for a minimum of one year and is subject to SEC regulations pertaining to our insiders. (2) Under the arrangement described in footnote (1) above, 10,000 shares were acquired and an additional 10,000 shares were issued to match this corresponding stock purchase in 1999. We recognized $75,062 of compensation expense related to this arrangement. The remaining $25,839 represents a housing and travel adjustment, for a total of $101,459. (3) Represents our 50% matching contribution up to 6% of annual compensation under our 401(k) Plan. (4) Performance bonus. (5) Represents $10,698 of accumulated vacation paid out, and $5,148 of our 50% matching contribution up to 6% of annual compensation under our 401(k) Plan. (6) Represents $9,747 of accumulated vacation paid out, and $4,769 of our 50% matching contribution up to 6% of annual compensation under our 401(k) Plan. (7) Represents a housing and travel adjustment. The foregoing compensation table does not include certain fringe benefits made available on a non-discriminatory basis to all of our employees such as group health insurance, dental insurance, long-term disability insurance, vacation and sick leave. In addition, we make available certain non-monetary benefits to our executive officers with a view to acquiring and retaining qualified personnel and facilitating job performance. We consider such benefits to be ordinary and incidental business costs and expenses. We also did not include in the table the aggregate value of such benefits in the case of the executive officers, which cannot be precisely ascertained but which is the lesser of either (a) 10% of the salary and bonus paid to 13 17 each such executive officer or to the group, respectively, or (b) $50,000 or $50,000 times the number of individuals in the group, as the case may be. OPTION GRANTS TABLE The following table provides information relating to the grant of stock options to our CEO and the Named Executive Officers during the fiscal year ended December 31, 2000 under our Stock Option Plan and our Incentive Plan. OPTION GRANTS IN LAST FISCAL YEAR POTENTIAL REALIZABLE VALUE AT ASSUMED ANNUAL RATES OF STOCK PRICE APPRECIATION FOR INDIVIDUAL GRANTS OPTION TERM(1) ------------------------------------------------------------ --------------------- NUMBER OF % OF TOTAL SECURITIES OPTIONS UNDERLYING GRANTED TO OPTIONS EMPLOYEES IN EXERCISE OR BASE EXPIRATION NAME GRANTED(#)(2) FISCAL YEAR PRICE ($/SH)(3) DATE 5%($) 10%($) ---- ------------- ------------ ---------------- ---------- -------- ---------- Mr. David R. Bethune............. 40,000 3.0% $ 9.719 4/19/10 244,489 619,583 100,000 7.4% 9.750 6/02/10 613,172 1,553,899 50,000 3.7% 9.500 8/03/10 298,725 757,028 50,000 3.7% 12.875 8/18/10 404,851 1,025,972 20,000 1.5% 15.125 9/05/10 190,241 482,107 Dr. Richard L. Jackson........... 25,000 1.8% $ 9.719 4/19/10 152,806 387,240 75,000 5.5% 9.750 6/02/10 459,879 1,165,424 20,000 1.5% 9.500 8/03/10 119,490 302,811 20,000 1.5% 12.875 8/18/10 161,940 410,389 10,000 0.7% 15.125 9/05/10 95,120 241,054 10,000 0.7% 18.125 12/08/10 113,987 288,866 Dr. J. Steven Garrett............ 20,000 1.5% $ 9.719 4/19/10 122,245 309,792 40,000 3.0% 9.750 6/02/10 245,269 621,560 10,000 0.7% 9.500 8/03/10 59,745 151,406 10,000 0.7% 12.875 8/18/10 80,970 205,194 10,000 0.7% 15.563 8/30/10 97,875 248,034 10,000 0.7% 15.125 9/05/10 95,120 241,054 Dr. Charles P. Cox............... 16,000 1.2% $ 9.719 4/19/10 97,796 247,833 20,000 1.5% 9.750 6/02/10 122,634 310,780 20,000 1.5% 9.500 8/03/10 119,490 302,811 10,000 0.7% 12.875 8/18/10 80,970 205,194 10,000 0.7% 15.125 9/05/10 95,120 241,054 10,000 0.7% 18.125 12/08/10 113,987 288,866 Dr. Richard L. Dunn.............. 14,000 1.0% $ 9.719 4/19/10 85,571 216,854 30,000 2.2% 9.750 6/02/10 183,952 466,170 5,000 0.4% 9.500 8/03/10 29,872 75,703 10,000 0.7% 12.875 8/18/10 80,970 205,194 10,000 0.7% 15.125 9/05/10 95,120 241,054 --------------- (1) Potential realizable value is based on an assumption that the stock price of the common stock appreciates at the annual rate shown (compounded annually) from the date of grant until the end of the ten-year option term. These numbers are calculated based on the requirements promulgated by the Securities and Exchange Commission and do not reflect our estimate of future stock price growth. (2) Vest and become exercisable at the rate of one-third on the first, second and third anniversaries of the grant date. (3) All options were granted at the fair market value of the shares on the date of grant based on the closing bid price for the shares on the Nasdaq National Market. 14 18 AGGREGATED OPTION EXERCISES AND FISCAL YEAR-END OPTION VALUES The following table provides information relating to the exercise of stock options during the year ended December 31, 2000 by our CEO and each of the Named Executive Officers and the 2000 fiscal year-end value of unexercised options. AGGREGATED OPTION EXERCISES IN LAST FISCAL YEAR AND FISCAL YEAR END OPTION VALUES NUMBER OF UNEXERCISED VALUE OF UNEXERCISED OPTIONS AT IN-THE-MONEY OPTIONS FISCAL YEAR END AT FISCAL YEAR END (#) ($)(1) SHARES ACQUIRED --------------- -------------------- ON EXERCISE VALUE REALIZED EXERCISABLE/ EXERCISABLE/ NAME (#) ($) UNEXERCISABLE UNEXERCISABLE ---- --------------- -------------- --------------- -------------------- Mr. David Bethune.......................... -0- $-0- 23,333/262,667 $206,062/$1,670,241 Dr. Richard Jackson........................ -0- $-0- 66,666/193,334 $420,829/$1,186,196 Dr. J. Steven Garrett...................... -0- $-0- 88,669/108,500 $ 647,004/$677,959 Dr. Charles P. Cox......................... -0- $-0- 74,008/102,033 $ 656,391/$568,616 Dr. Richard L. Dunn........................ -0- $-0- 52,248/76,167 $ 417,850/$435,672 --------------- (1) Market value of underlying shares is (i) the fair market value at December 31, 2000 ($17.0625 per share) less the option exercise price, multiplied by (ii) the number of shares in the money. EMPLOYMENT AGREEMENTS On April 17, 1995, we entered into an employment agreement with Dr. Garrett. Pursuant to the terms of the agreement, Dr. Garrett's duties are to act as Vice President of Dental Clinical Research. The employment agreement provides that Dr. Garrett receive a starting annual base salary of $150,000 (which at the discretion of our Board, upon recommendation by our compensation committee, may be increased annually). Dr. Garrett's agreement provides for severance pay at full salary and benefits until the earlier of one year from the date of termination or until re-employment; and for the immediate vesting of all unvested options, in case of termination other than for cause. Dr. Garrett's base salary was increased to $190,000 effective January 1, 1999. On November 1, 1998, we entered into an employment agreement with Dr. Richard Jackson. Pursuant to the terms of the agreement, Dr. Jackson's duties are to act as Senior Vice President of Research and Development. The employment agreement provides that Dr. Jackson receive a starting annual base salary of $250,000. The base salary, at the discretion of our Board, upon recommendation by our compensation committee, may be increased annually. Upon entering into the agreement, Dr. Jackson received options to purchase 100,000 shares, which options vest in three equal annual installments. Dr. Jackson's agreement provides for severance pay at a full salary for one year from the date of termination. The agreement also provides that we will pay insurance benefits until the earlier of one year from the date of termination or until re-employment and provides for the immediate vesting of all unvested options, in case of termination other than for cause or upon a change of control. On August 3, 1999, we entered into an agreement with Mr. Bethune. Pursuant to the terms of the agreement, Mr. Bethune's duties are to act as Chief Executive Officer. The employment agreement provides that Mr. Bethune receive a monthly base salary of $21,250. Mr. Bethune's agreement provides him the right to purchase 50,000 shares and receive an equivalent number of matching restricted shares. The agreement does not provide for any severance pay or benefits. 15 19 COMPENSATION PURSUANT TO PLANS Stock Option Plans. We have four stock option plans under which options may currently be granted, the Incentive Plan, the Stock Option Plan, Non-Qualified Stock Option Plan and Non-Employee Director Stock Plan. The persons eligible to receive options, the number of options authorized and outstanding, and the number of options granted during the preceding fiscal year under each plan are as follows: # OPTIONS # OPTIONS # OPTIONS GRANTED NAME OF PLAN PERSONS ELIGIBLE AUTHORIZED OUTSTANDING(1) IN 2000 ------------ -------------------- ---------- -------------- ----------------- Stock Option Plan.............................. Employees and 2,500,000 1,509 289,450 directors Incentive Plan................................. Employees, directors 1,750,000(2) 553,325 1,064,325 and consultants Non-Qualified Stock Option Plan................ Consultants 150,000 3,040 20,000 Non-Employee Directors Stock Plan.............. Non-Employee 25,000 19,433 3,092 Directors --------------- (1) Any unexercised options that expire or terminate in accordance with the plan become available again for issuance under the plan. (2) The Board proposes that the stockholders approve an amendment to the executive plan at the meeting to increase the number of shares that may be issued pursuant to the exercise of options granted thereunder to 2,750,000. 401(k) Plan. We maintain a defined contribution savings plan, or the 401(k) Plan, to provide retirement income to our employees, including all executive officers. All employees who are over 21 years of age are eligible to participate in our 401(k) Plan. It is funded by voluntary pre-tax contributions from employees up to a maximum amount equal to 17% of annual compensation up to $10,000 and by 50% matching contributions by us up to 6% of annual compensation. Employees who have completed one year of service are eligible for the 50% company match. Participants are fully vested in all pre-tax, after-tax and matching contributions as soon as they are made. Employee Stock Purchase Plan. We maintain an employee stock purchase plan, or the ESPP, which provides eligible employees the opportunity to purchase shares of our common stock through authorized payroll deductions at 85% of the average market price on the last day of each quarter. All employees who have completed six months of employment of 20 hours per week or greater are eligible to participate in our ESPP. This plan qualifies as an "employee stock purchase plan" under Section 423 of the Code. Currently, 286,000 shares are available for purchase under our ESPP. COMPENSATION OF DIRECTORS Each non-employee director receives an annual retainer fee of $8,000 ($10,000 for a non-employee Chairman of our Board) which is paid in quarterly installments. Each non-employee director may elect to apply all or any portion of the annual retainer fee to the acquisition of restricted shares or the receipt of stock options in accordance with the terms of the Non-Employee Director Stock Plan. In May 2000, the retainer of $8,000 ($10,000 for the Chairman of the Board) was eliminated by the Board and each non-employee director was granted 2,800 stock options in lieu of the annual retainer. In addition, under our Non-Employee Director Stock Plan, immediately following each annual meeting of stockholders, each non-employee director is granted a non-qualified stock option to purchase 4,000 shares (5,000 shares in the case of a non-employee Chairman of our Board). The options vest in three equal annual installments. We also reimburse expenses of directors for attending meetings. Our directors who are also officers do not receive any additional compensation for their service as members of the board of directors. 16 20 REPORT OF THE COMPENSATION COMMITTEE The compensation committee of our Board is responsible for establishing compensation policy and administering the compensation programs of our executive officers. The compensation committee is currently comprised of three independent outside directors. The compensation committee meets at least once a year to review executive compensation policies, design of compensation programs, and individual salaries and awards for our executive officers based on performance criteria. Pursuant to the rules regarding disclosure of company polices concerning executive compensation, this report is submitted by Mr. Flaum, Mr. Urheim and Dr. Cohen in their capacities as members of our compensation committee for the year ended December 31, 2000 and addresses our compensation policies as they affected Mr. Bethune, the CEO, and our other executive officers, including the Named Executive Officers. EXECUTIVE COMPENSATION PHILOSOPHY We apply a consistent philosophy to compensation for all of our employees, including executive officers. This philosophy is based on the premise that our achievements result from the coordinated efforts of all individuals working toward common objectives. The goals of the executive compensation program are to align compensation with business objectives and performance, and to enable us to attract, retain and reward executive officers who contribute to our long-term success. Our compensation program for executive officers is based on the same principles applicable to compensation decisions for all of our employees and generally consists of two compensation elements: cash and equity. However, over the past two years the cash element has remained relatively constant and we have relied more heavily on equity as a form of compensation. The process used by us in determining executive officer compensation levels for each of the two components takes into account both qualitative and quantitative factors. Among the factors considered by us are the recommendations of the CEO with respect to the compensation of our other key executive officers. However, we make the final compensation decisions concerning such officers. In making compensation decisions, we consider compensation practices and financial performance of the company's peer group. We use this information to guide us, but we do not target total executive compensation or any component thereof to any particular point within, or outside, the range of peer group results. However, we believe that compensation at or near the weighted average of the peer group for base salaries is generally appropriate for us to use as a guideline for compensation decisions. The specified weighted averages are considered on both an absolute basis and a size-adjusted basis (i.e., reflecting compensation levels that are commensurate with the company's size relative to the sizes of the peer group companies). Specific compensation for individual executive officers will vary from these levels as the result of other factors considered by us unrelated to compensation practices of the peer group. The peer group is comprised of biotech and pharmaceutical companies that are among those entities who participate in an annual biotechnological survey conducted by Radford Associates in conjunction with Aon Consulting Group. The 2000 survey included information on 152 public and private companies from the group of 50 to 149 employees. The Compensation Committee does not believe that Code Section 162(m), which denies a deduction for compensation payments in excess of $1,000,000 to the CEO or a Named Executive Officer, is likely to be applicable to the company in the near future. We will reconsider the implication of Section 162(m) if and when it appears that the section may become applicable. COMPENSATION ELEMENTS For the year ended December 31, 2000, our executive compensation program included a base salary and grants of stock options. 17 21 Base Salary. We determine salaries for executive officers by evaluating subjectively the responsibilities of the position held and the experience and performance of the individual and comparing base salaries for comparable positions at peer group entities. Our board of directors and management believe that our company has exceeded its goals for 2000; however, because of our continuing efforts to conserve cash, base salaries for executives in 2000 remained the same as in 1999. In lieu of cash, additional stock options were granted to executives in an effort to keep compensation expense at the same level. We have not yet determined base salaries for 2001, but in doing so we will review peer group data and rely on the recommendation of the CEO for each executive position. In addition, we will review the responsibility level of each position, together with the executive officer's individual performance for the prior year and objectives for the current year. Finally, we will compare the company's performance to objectives for the prior year and performance targets for the current year. In determining the CEO's base salary for 2001, we reviewed the peer group data, compared the company's performance to its stated objectives in 2000, and considered performance targets for 2001. Our management and board of directors believe that the company and the CEO exceeded stated goals for 2000; however, because of our efforts to conserve cash, Mr. Bethune's cash compensation in 2001 remained unchanged from 2000. In recognition of Mr. Bethune's achievements and the company's performance under his leadership, and in an effort to further align his interests with those of our stockholders, Mr. Bethune was granted an option to purchase 100,000 shares of our common stock effective January 2, 2001. The option will vest on a pro rata basis over a three-year period. Stock Options. The long-term incentive component of the CEO's and the executive officers' compensation is stock options. We believe that providing executive officers with opportunities to acquire significant equity positions in the company and thus, the opportunity to share in its growth and prosperity, through the grant of stock options will enable the company to attract and retain qualified and experienced executive officers. Stock options represent a valuable portion of the compensation program for our executive officers. The exercise price of stock options is the fair market value of the shares on the date of the grant based on the closing bid price of the shares on the date of grant, and will only provide a benefit if the value of the shares increases. Grants of stock options to executive officers are made by us upon the recommendation of the CEO and are based upon a review of peer group and the company's relative size data within the 2000 survey. Each executive officer's position is compared to grants of officers in similar positions. We also evaluate the executive officer's past and expected future performance, the number of outstanding and previously granted options, and discussions with the executive officer when we grant options. COMPENSATION COMMITTEE INTERLOCKS AND INSIDER PARTICIPATION In fiscal 2000, the members of the compensation committee were Mr. Sander A. Flaum, Mr. John E. Urheim, and Dr. D. Walter Cohen. Mr. Campbell served on the compensation committee until November 2000 at which time he resigned. Mr. Urheim replaced Mr. Campbell in November 2000. Mr. Urheim served as our Vice Chairman and Chief Executive Officer from June 1993 to August 1999. COMPENSATION COMMITTEE Sander A. Flaum, Chairman John E. Urheim Dr. D. Walter Cohen 18 22 PERFORMANCE GRAPH The graph and table below compare the total stockholder returns (assuming reinvestment of dividends) of the company's shares, the Nasdaq Pharmaceutical Index and the Nasdaq Index. The graph assumes $100 invested on January 1, 1995 in the shares and each of the indices. The stock price performance shown on the graph below is not necessarily indicative of the future price performance. [PERFORMANCE GRAPH] --------------------------------------------------------------------------------------------------------------------- Date 12/31/95 12/31/96 12/31/97 12/31/98 12/31/99 12/31/00 --------------------------------------------------------------------------------------------------------------------- Company Index 100.00 138.71 190.32 114.52 66.94 220.16 Nasdaq Pharmaceutical 100.00 100.31 103.66 131.95 248.01 308.49 Nasdaq Total 100.00 123.04 150.69 212.51 394.92 237.62 NOTWITHSTANDING ANYTHING TO THE CONTRARY SET FORTH IN ANY OF OUR PREVIOUS FILINGS UNDER THE SECURITIES ACT OF 1933 OR THE SECURITIES EXCHANGE ACT OF 1934 THAT MIGHT INCORPORATE FUTURE FILINGS, INCLUDING THIS PROXY STATEMENT, IN WHOLE OR IN PART, THE PRECEDING REPORT OF THE COMPENSATION COMMITTEE AND PERFORMANCE GRAPH SHALL NOT BE INCORPORATED BY REFERENCE INTO ANY SUCH FILINGS. AUDIT COMMITTEE REPORT The following is a report of the audit committee with respect to our audited financial statements for the fiscal year ended December 31, 2000, which include our consolidated balance sheets as of December 31, 2000 and 1999, and the related consolidated statements of operations, stockholders' equity (deficit) and cash flows for each of the three years in the period ended December 31, 2000, and the notes thereto. The board of directors has adopted a written audit committee charter, a copy of which is attached to this proxy statement as Appendix A. In general the charter sets forth: - the scope of the audit committee's responsibilities and the means by which it carries out these responsibilities; - the outside auditor's accountability to the board of directors and the audit committee; and - the audit committee's responsibility to ensure the independence of the outside auditor. 19 23 REVIEW WITH MANAGEMENT We have reviewed and discussed the company's audited financial statements with management. REVIEW AND DISCUSSIONS WITH INDEPENDENT ACCOUNTANTS We have discussed with Deloitte & Touche, the company's independent accountants, the matters required to be discussed by SAS 61 (Codification of Statements on Accounting Standards) which includes, among other items, matters related to the conduct of the audit of the company's financial statements. We have also received written disclosures and the letter from Deloitte & Touche LLP required by Independence Standards Board Standard No. 1 (which relates to the accountant's independence from the company and its related entities) and have discussed with Deloitte & Touche LLP their independence from the company. In addition, we have also considered whether the provision of those services set forth in the table below is compatible with Deloitte & Touche LLP maintaining its independence from the company. CONCLUSION Based on the review and discussions referred to above, we recommended to the company's board of directors that the company's audited financial statements be included in the company's Annual Report on Form 10-K for the fiscal year ended December 31, 2000. AUDIT COMMITTEE H. Stuart Campbell, Chairman C. Rodney O'Connor Sander A. Flaum AUDIT FEES The following table sets forth the aggregate fees billed by Deloitte & Touche LLP for the following services during fiscal 2000: DESCRIPTION OF SERVICES FEE AMOUNT ----------------------- ---------- Audit fees(1)........................................... $152,547 All other fees.......................................... $ -- -------- Total......................................... $152,547 ======== --------------- (1) Represents the aggregate fees billed for professional services rendered for the audit of the company's annual financial statements during fiscal 2000 and for the review of the financial statements included in the company's quarterly reports during such period. 20 24 PROPOSAL NO. 4 RATIFICATION OF SELECTION OF INDEPENDENT AUDITORS Our Board, upon the recommendation of our audit committee, has selected Deloitte & Touche LLP as our independent auditors for the year ending December 31, 2001. Representatives of Deloitte & Touche LLP will be present at the meeting and will have the opportunity to make a statement if they desire to do so and will be available to respond to appropriate questions from stockholders. Although it is not required to do so, our Board is submitting its selection of our independent auditors for ratification by our Stockholders at the meeting in order to ascertain the views of stockholders regarding such selection. A majority of the votes cast at the meeting, if a quorum is present, will be sufficient to ratify the selection of Deloitte & Touche LLP as our independent auditors for the year ending December 31, 2001. Whether the proposal is approved or defeated, our Board may reconsider its selection. OUR BOARD OF DIRECTORS RECOMMENDS THAT THE STOCKHOLDERS VOTE FOR THE RATIFICATION OF THE SELECTION OF INDEPENDENT AUDITORS SECURITY OWNERSHIP OF CERTAIN BENEFICIAL OWNERS AND MANAGEMENT The following table sets forth certain information regarding beneficial ownership of outstanding shares as of the record date, by (i) each person who is known by us to own beneficially five percent or more of the outstanding shares, (ii) each of our directors, (iii) the CEO and each Named Executive Officer, and (iv) all directors and executive officers as a group. SHARES BENEFICIALLY PERCENT NAME OWNED(1) OF CLASS ---- ------------ -------- Elan International Services, Ltd.(2)........................ 1,442,478 9.9% Sanofi-Synthelabo Inc.(3)................................... 824,572 6.0% Mr. David R. Bethune........................................ 148,477 1.09% Mr. H. Stuart Campbell...................................... 35,228(4) * Dr. D. Walter Cohen......................................... 26,371 * Dr. Charles P. Cox.......................................... 87,341 * Dr. Richard L. Dunn......................................... 135,665 * Mr. Sander Flaum............................................ 9,364 * Dr. J. Steven Garrett....................................... 98,256 * Dr. Richard Jackson......................................... 125,000 * Mr. C. Rodney O'Connor...................................... 98,999 * Mr. Nicolas Bazan........................................... -0- * All executive officers and directors as a group (18 persons).................................................. 1,473,256 10.35% --------------- * Less than 1% (1) Shares are considered beneficially owned, for purposes of this table, only if held by the person indicated, or if such person, directly or indirectly, through any contract, arrangement, understanding, relationship or otherwise has or shares the power to vote, to direct the voting of and/or to dispose of or to direct the disposition of such security, or if the person has the right to acquire beneficial ownership within 60 days, unless otherwise indicated. The foregoing share amounts include the following number of shares which may be acquired pursuant to stock options exercisable within 60 days of the record date: Mr. Bethune, 14,667 shares, Mr. Campbell, 2,667 shares; Dr. Cohen, 2,667 shares; Dr. Cox, 5,333 shares; Dr. Dunn, 4,666 shares; Mr. Flaum, 1,333 shares, Dr. Garrett, 6,667 shares; Dr. Jackson, 8,334; Mr. O'Connor, 2,666 shares; and all executive officers and directors as a group, 71,167 shares. (2) Information is based upon the Schedule 13D filed by Elan International Services, Ltd., on August 7, 2000. Elan International's business address is 102 St. James Court, Flatts, Smiths Parish, FL 04, 21 25 Bermuda. The shares beneficially owned include 1,000,000 shares which may be acquired pursuant to the exercise of warrants. (3) The business address of Sanofi-Synthelabo Inc. is 90 Park Avenue, New York, New York 10016. (4) Includes 57 shares held by Mr. Campbell's wife. Mr. Campbell disclaims any beneficial interest in all shares held by this wife. SECTION 16(A) BENEFICIAL OWNERSHIP REPORTING COMPLIANCE Section 16(a) of the Securities Exchange Act of 1934, as amended, and the rules thereunder require our executive officers and directors, and persons who own more than 10% of a registered class of our equity securities, to file reports of ownership and changes in ownership with the Securities and Exchange Commission, the NASD, and us. Based solely on our review of Section 16(a) forms received by us and written representations that no other reports were required, we believe that, during the last fiscal year, all Section 16(a) filing requirements applicable to our executive officers, directors and 10% beneficial owners were complied with. CERTAIN RELATIONSHIPS AND RELATED TRANSACTIONS We have entered into various employment agreements with our executive officers, which are discussed under "Executive Compensation-Employment Agreements." In December 2000, we entered into an exclusive North American marketing agreement with Sanofi-Synthelabo, a major international pharmaceutical company, for One-month, Three-month, and Four-month Leuprogel. Under the terms of the agreement, we are to receive a license fee, research and development support and payments for certain clinical, regulatory and sales milestones. We will also receive royalty payments based on sales of the Leuprogel products upon approval for marketing by the FDA. As part of the agreement, Sanofi-Synthelabo purchased approximately $15 million of our common stock. In addition to the prostate cancer products, Sanofi-Synthelabo received an option to develop a six-month product for prostate cancer, as well as additional Leuprogel products for other indications. Sanofi-Synthelabo owns more than five percent of our outstanding common stock. On August 2, 1999, we entered into a severance agreement with John E. Urheim, a director and our former CEO. Under the agreement, Mr. Urheim is entitled to receive $255,000 over a period of twelve months commencing September 1, 1999 and ending August 31, 2000 and is entitled to receive health benefits during the same period of time. In addition, unvested options to acquire up to 28,034 shares became immediately vested as of the date of the agreement. In 2000, Mr. Urheim received $126,926 in consulting fees for the set-up and promotion of the European sales program. On July 18, 2000, we formed a joint venture with Elan International Services, Ltd., a wholly owned subsidiary of Elan Corporation, plc. The joint venture is a Bermuda limited company and is initially owned 80.1% by us and 19.9% by Elan. Its purpose is to develop and commercialize oncology and pain management products. In a related transaction, Elan purchased 12,015 shares of our Series A convertible exchangeable preferred stock on July 18, 2000 for $12,015,000. We used the proceeds of the preferred stock sale to purchase 6,000 shares of the joint venture's common stock and 3,612 shares of its preferred stock to fund our share of the joint venture's initial capitalization. Elan may also loan us up to $8,010,000 to support our share of the joint venture's research and development costs pursuant to a convertible promissory note issued by us to Elan. Elan purchased 442,478 shares of our common stock for $5,000,000 and we issued Elan a five-year warrant to purchase up to 1,000,000 shares of our common stock for $18 per share in conjunction with the formation of the joint venture. 22 26 SOLICITATION OF PROXIES This solicitation is being made by mail on behalf of our Board, but may also be made without additional remuneration by our officers or employees by telephone, telegraph, facsimile transmission, e-mail or personal interview. We will bear the expense of the preparation, printing and mailing of the enclosed form of proxy, notice of annual meeting and this proxy statement and any additional material relating to the meeting which may be furnished to our stockholders by our Board subsequent to the furnishing of this proxy statement. We will reimburse banks and brokers who hold shares in their name or custody, or in the name of nominees for others, for their out-of-pocket expenses incurred in forwarding copies of the proxy materials to those persons for whom they hold such shares. To obtain the necessary representation of stockholders at the meeting, supplementary solicitations may be made by mail, telephone or interview by officers or employees of us, without additional compensation, or selected securities dealers. We anticipated that the cost of such supplementary solicitations, if any, will not be material. ANNUAL REPORT We have mailed our Annual Report for 2000 to our stockholders along with this proxy statement. WE WILL, UPON WRITTEN REQUEST AND WITHOUT CHARGE, PROVIDE TO ANY PERSON, SOLICITED HEREUNDER, A COPY OF OUR ANNUAL REPORT ON FORM 10-K FOR THE YEAR ENDED DECEMBER 31, 2000, INCLUDING FINANCIAL STATEMENTS AND FINANCIAL STATEMENT SCHEDULES, AS FILED WITH THE SECURITIES AND EXCHANGE COMMISSION. Requests should be addressed to Investor Relations, 2579 Midpoint Drive, Fort Collins, Colorado 80525. OTHER MATTERS We are not aware of any business to be presented for consideration at the meeting, other than those specified in the notice of annual meeting. If any other matters are properly presented at the meeting, the persons named in the enclosed proxy will vote in accordance with their best judgment. STOCKHOLDER PROPOSALS If you intend to submit a proposal at the Annual Meeting of Stockholders for the year ended 2001 and wish to have the proposal considered for inclusion in the proxy statement and form of proxy for that meeting, you must comply with the applicable laws and regulations governing submission of such proposals and must deliver the proposal to us for consideration no later than December 5, 2001. If you submit a proposal to our Annual Meeting of Stockholders for the year ended 2001 outside the requirements of Rule 14a-8 under the Securities Exchange Act of 1934, it will be considered untimely for purposes of Rule 14a-4 and 14a-5 if we receive notice thereof after February 18, 2002. You should send such proposal to our Corporate Secretary at 2579 Midpoint Drive, Fort Collins, Colorado 80525. 23 27 NOTICE TO BANKS, BROKER-DEALERS AND VOTING TRUSTEES AND THEIR NOMINEES Please advise us whether other persons are the beneficial owners of the shares for which proxies are being solicited from you, and, if so, the number of copies of this proxy statement and other soliciting materials you wish to receive in order to supply copies to the beneficial owners of the shares. IT IS IMPORTANT THAT PROXIES BE RETURNED PROMPTLY. THEREFORE, WE REQUEST THAT WHETHER OR NOT YOU EXPECT TO ATTEND THE MEETING IN PERSON, YOU COMPLETE, DATE AND SIGN THE ENCLOSED FORM OF PROXY AND RETURN IT PROMPTLY IN THE ENCLOSED ENVELOPE. BY RETURNING YOUR PROXY PROMPTLY YOU CAN HELP US AVOID THE EXPENSE OF FOLLOW-UP MAILINGS TO ENSURE A QUORUM SO THAT THE MEETING CAN BE HELD. STOCKHOLDERS WHO ATTEND THE MEETING MAY REVOKE A PRIOR PROXY AND VOTE THEIR PROXY IN PERSON AS SET FORTH IN THIS PROXY STATEMENT. By Order of the Board of Directors, /s/ DAVID R. BETHUNE David R. Bethune Chairman of the Board and Chief Executive Officer Fort Collins, Colorado April 4, 2001 24 28 APPENDIX A CHARTER OF THE AUDIT COMMITTEE ATRIX LABORATORIES, INC. PURPOSE AND AUTHORITY The audit committee (the "Committee") for Atrix Laboratories, Inc., a Delaware company (the "Company"), is appointed by the Company's Board of Directors (the "Board") to assist the Board in monitoring (1) the integrity of the financial statements of the Company, (2) the compliance by the Company with legal and regulatory requirements and (3) the independence and performance of the Company's internal and external auditors. The Committee shall have the authority to retain special legal, accounting or other consultants to advise the Committee and, if necessary, to institute special investigations. The Committee may request any officer or employee of the Company or the Company's outside counsel or independent auditor to attend a meeting of the Committee or to meet with any members of, or consultants to, the Committee. In addition, the Committee shall undertake those specific duties and responsibilities listed below and such other duties as the Board shall from time to time prescribe. COMMITTEE MEMBERSHIP The Committee members (the "Members") shall be appointed by the Board, and will serve at the discretion of the Board. The Committee will consist of at least three (3) members of the Board subject to the following requirements: (i) each of the Members must be able to read and understand fundamental financial statements, including a company's balance sheet, income statement, and cash flow statement or must become able to do so within a reasonable time period after his or her appointment to the Committee; (ii) at least one (1) of the Members must have past employment experience in finance or accounting, requisite professional certification in accounting, or other comparable experience or background, including a current or past position as a chief executive or financial officer or other senior officer with financial oversight responsibilities; and (iii) each Member must be either (a) an independent director or (b) the Board must determine it to be in the best interests of the Company and its stockholders to have one (1) director who is not independent, and the Board must disclose the reasons for its determination in the Company's first annual proxy statement subsequent to such determination, as well as the nature of the relationship between the Company and director. Under such circumstances the Company may appoint one (1) director who is not independent to the Committee, so long as the director is not a current employee or officer, or an immediate family member of a current employee or officer. DUTIES AND RESPONSIBILITIES The Committee shall report, at least annually, to the Board. Further, the Committee shall: 1. Review and reassess the adequacy of this Charter annually and recommend any proposed changes to the Board for approval; 2. Review the annual audited financial statements with management, including a review of major issues regarding accounting and auditing principles and practices, and evaluate the adequacy of internal controls that could significantly affect the Company's financial statements; A-1 29 3. Review an analysis prepared by management and the independent auditor of significant financial reporting issues and judgments made in connection with the preparation of the Company's financial statements; 4. Review with management and the independent auditor the Company's quarterly financial statements prior to the filing of its Form 10-Q; 5. Meet periodically with management to review the Company's major financial risk exposures and the steps management has taken to monitor and control such exposures; 6. Review major changes to the Company's auditing and accounting principles and practices as suggested by the independent auditor, internal auditors or management; 7. Recommend to the Board the appointment of the independent auditor, which firm is ultimately accountable to the Committee and the Board; 8. Approve the fees to be paid to the independent auditor; 9. Receive periodic reports from the independent auditor regarding the auditor's independence, discuss such reports with the auditor, and if deemed necessary by the Committee, take or recommend that the full Board take appropriate action to satisfy itself of the independence of the auditor; 10. Evaluate together with the Board the performance of the independent auditor and, if deemed necessary by the Committee, recommend that the Board replace the independent auditor; 11. Review the appointment of, and any replacement of, the senior internal auditing executive; 12. Review the significant reports to management prepared by the internal auditing department and management's responses; 13. Meet with the independent auditor prior to the audit to review the planning and staffing of the audit; 14. Obtain from the independent auditor assurance that Section 10A of the Securities Exchange Act of 1934 has not been implicated. 15. Obtain reports from management, the Company's senior internal auditing executive and the independent auditor that the Company's subsidiary/foreign affiliated entities are in conformity with applicable legal requirements, including the Foreign Corrupt Practices Act, and the Company's code of conduct. 16. Discuss with the independent auditor the matters required to be discussed by Statement on Auditing Standards No. 61 relating to the conduct of the audit. 17. Review with the independent auditor any problems or difficulties the auditor may have encountered, any management letter provided by the auditor, and the Company's response to that letter. Such review should include: a. Any difficulties encountered in the course of the audit work, including any restrictions on the scope of activities or access to required information; b. Any changes required in the planned scope of the internal audit; and c. The internal audit department responsibilities, budget and staffing. 18. Prepare the report required by the rules of the Securities and Exchange Commission to be included in the Company's annual proxy statement in accordance with the requirements of Item 306 of Regulation S-K and S-B and item 7(e)(3) of Schedule 14A; 19. Advise the Board with respect to the Company's policies and procedures regarding compliance with applicable laws and regulations and with the Company's Code of Conduct; A-2 30 20. Review with the Company's outside counsel legal matters that may have a material impact on the financial statements, the Company's compliance policies and any material reports or inquiries received from regulators or governmental agencies; 21. Review related party transactions for potential conflict of interest; and 22. Provide oversight and review of the Company's asset management policies, including an annual review of the Company's investment policies and performance for cash and short-term investments. While the Committee has the responsibilities and powers set forth in this Charter, it is not the duty of the Committee to plan or conduct audits or to determine that the Company's financial statements are complete and accurate and are in accordance with generally accepted accounting principles. This is the responsibility of management and the independent auditor. Nor is it the duty of the Committee to conduct investigations, to resolve disagreements, if any, between management and the independent auditor or to assure compliance with laws and regulations and the Company's Code of Conduct. MEETINGS The Committee will meet at least two times each year. The Committee may establish its own schedule and notify the Board. The Committee will meet at least annually with the chief financial officer, the senior internal auditing executive, and the independent auditor in separate executive sessions. The Committee will meet with the independent auditors of the Company, at such times as it deems appropriate, to review the independent auditor's examination and management report. MINUTES The Committee will maintain written minutes of its meetings, which minutes will be filed with the minutes of the meetings of the Board. A-3 31 PROXY ATRIX LABORATORIES, INC. THIS PROXY IS SOLICITED ON BEHALF OF THE BOARD OF DIRECTORS FOR THE ANNUAL MEETING OF STOCKHOLDERS TO BE HELD MAY 7, 2001 The undersigned stockholder of Atrix Laboratories, Inc. hereby constitutes and appoints Desiree Calvelage and Brian G. Richmond and each of them, proxies, with full power of substitution, for and on behalf of the undersigned to vote, as designated below, according the number of shares of the Company's $.001 par value common stock held of record by the undersigned on March 21, 2001, and as fully as the undersigned would be entitled to vote if personally present at the Annual Meeting of Stockholders of the Company to be held at The Fort Collins Marriott, 350 East Horsetooth Road, Fort Collins, Colorado on May 7, 2001 at 10:00 a.m. local time, and at any and all postponements, continuations and adjournments thereof. THIS PROXY WHEN PROPERLY EXECUTED WILL BE VOTED IN THE MANNER DIRECTED HEREIN BY THE UNDERSIGNED. IF PROPERLY EXECUTED AND NO DIRECTION IS MADE, THIS PROXY WILL BE VOTED FOR THE ELECTION OF PROPOSED NOMINEES TO THE BOARD OF DIRECTORS OF THE COMPANY AND FOR EACH OTHER PROPOSAL. 1. Proposal to elect the following nominees to the board of directors: [ ] FOR all nominees listed [ ] WITHHOLD AUTHORITY to below (except as marked vote all nominees listed to the contrary below) below Mr. David R. Bethune Dr. Richard L. Jackson Dr. Nicolas Bazan (INSTRUCTION: To withhold authority to vote for any individual nominee, write that nominee's name on the space provided below:) 2. Approve the Amendment to the 2000 Stock Incentive Plan [ ] FOR [ ] AGAINST [ ] ABSTAIN 3. Approve the Amendment to the Certificate of Incorporation. [ ] FOR [ ] AGAINST [ ] ABSTAIN 4. Proposal for ratification of selection of Deloitte & Touche LLP as the Company's independent auditors for the year ending December 31, 2001: [ ] FOR [ ] AGAINST [ ] ABSTAIN 5. In the discretion of such proxies, upon such other business as may properly come before the meeting or any and all postponements, continuations or adjournments thereof. The undersigned hereby acknowledges receipt of the notice of annual meeting of Stockholders dated April 4, 2001 and the proxy statement furnished therewith. Please sign exactly as your name appears hereon. When shares are held by joint tenants, both should sign. Executors, administrators, trustees and other fiduciaries, and persons signing on behalf of corporations or partnerships, should so indicate. Dated , 2001 --------------------- ------------------------------------ Authorized Signature ------------------------------------ Title ------------------------------------ Authorized Signature ------------------------------------ Title PLEASE MARK BOXES [X] IN INK. SIGN, DATE AND RETURN THIS PROXY CARD PROMPTLY USING THE ENCLOSED ENVELOPE.