------------------------------ OMB APPROVAL ------------------------------ OMB NUMBER 3235-0287 Expires: January 31, 2005 Estimated average burden hours per response.........0.5 ------------------------------ UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 FORM 4 STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(f) of the Investment Company Act of 1940 |_| Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b). (Print or Type Responses) ================================================================================ 1. Name and Address of Reporting Person* -------------------------------------------------------------------------------- (Last) (First) (Middle) Osser Leonard -------------------------------------------------------------------------------- (Street) c/o Milestone Scientific Inc. 220 South Orange Avenue -------------------------------------------------------------------------------- (City) (State) (Zip) Livingston New Jersey 07039 ================================================================================ 2. Issuer Name and Ticker or Trading Symbol Milestone Scientific Inc. AMEX - "MS" ================================================================================ 3. IRS Identification Number of Reporting Person, if entity (Voluntary) ================================================================================ 4. Statement for Month/Year September 2002 ================================================================================ 5. If Amendment, Date of Original (Month/Year) ================================================================================ 6. Relationship of Reporting Person(s) to Issuer (Check all applicable) |X| Director |X| 10% Owner |X| Officer |_| Other (give title below) (specify below) Chief Executive Officer ================================================================================ 7. Individual or Joint/Group Filing (Check Applicable Line) |X| Form filed by One Reporting Person |_| Form filed by More than One Reporting Person ================================================================================ Table I -- Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned ================================================================================ 6. 4. 5. Owner- Securities Acquired (A) or Amount of ship 3. Disposed of (D) Securities Form: 7. Transaction (Instr. 3, 4 and 5) Beneficially Direct Nature of 2. Code ---------------------------- Owned at End (D) or Indirect 1. Transaction (Instr. 8) (A) of Month Indirect Beneficial Title of Security Date ------------ Amount or Price (Instr. 3 (I) Ownership (Instr. 3) (mm/dd/yy) Code V (D) and 4) (Instr.4) (Instr. 4) ------------------------------------------------------------------------------------------------------------------------------------ ------------------------------------------------------------------------------------------------------------------------------------ Common Stock 09/11/02 P 100,000 A $.398 2,865,244 D ------------------------------------------------------------------------------------------------------------------------------------ ------------------------------------------------------------------------------------------------------------------------------------ ------------------------------------------------------------------------------------------------------------------------------------ ------------------------------------------------------------------------------------------------------------------------------------ ==================================================================================================================================== (Over) Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly. *If the form is filed by more than one reporting person, see Instruction 4(b)(v). SEC 1474 (2-02) Potential persons who are to respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB control number SEC 1474(2-02) FORM 4 (continued) Table II -- Derivative Securities Acquired, Disposed of, or Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities) ================================================================================ 9. 10. Number Owner- of ship 2. Deriv- Form of Conver- 5. 7. ative Deriv- 11. sion Number of Title and Amount Secur- ative Nature or Derivative 6. of Underlying 8. ities Secur- of Exer- 4. Securities Date Securities Price Bene- ity: In- cise 3. Trans- Acquired (A) Exercisable and (Instr. 3 and 4) of ficially Direct direct Price Trans- action or Disposed Expiration Date ---------------- Deriv- Owned (D) or Bene- 1. of action Code of(D) (Month/Day/Year) Amount ative at End In- ficial Title of Deriv- Date (Instr. (Instr. 3, ---------------- or Secur- of direct Owner- Derivative ative (Month/ 8) 4 and 5) Date Expira- Number ity Month (I) ship Security Secur- Day/ ------ ------------ Exer- tion of (Instr.(Instr. (Instr. (Instr. (Instr. 3) ity Year) Code V (A) (D) cisable Date Title Shares 5) 4) 4) 4) ------------------------------------------------------------------------------------------------------------------------------------ ------------------------------------------------------------------------------------------------------------------------------------ Options to purchase Common Stock common stock $ 16.00 1/9/98 A A 1/9/99 1/9/03 par value $.001 50,000 D ------------------------------------------------------------------------------------------------------------------------------------ Options to purchase Common Stock common stock $ 1.00 1/1/99 A A 1/9/00 1/9/04 par value $.001 50,000 D ------------------------------------------------------------------------------------------------------------------------------------ Options to purchase Common Stock common stock $ .875 1/1/00 A A 1/1/01 1/1/05 par value $.001 50,000 D ------------------------------------------------------------------------------------------------------------------------------------ Options to purchase Common Stock common stock $ 2.00 1/4/01 A A 1/4/02 1/4/06 par value $.001 50,000 D ------------------------------------------------------------------------------------------------------------------------------------ Options to purchase Common Stock common stock $ .68 1/2/02 A A 1/2/03 1/2/07 par value $.001 50,000 D ------------------------------------------------------------------------------------------------------------------------------------ Options to purchase Common Stock common stock $ 1.75 2/1/00 A A 2/1/00 2/1/05 par value $.001 35,714 D ------------------------------------------------------------------------------------------------------------------------------------ Options to purchase Common Stock common stock * 1/2/02 A A 1/2/02 1/31/07 par value $.001 614,183 D ----------------------------------------------------------------------------------------------------------------------------------- ==================================================================================================================================== * The exercise price for any of these option is $.80 through 1/31/03, $1.00 from 2/1/03 through 1/31/06 and $2.00 from 2/1/06 through 1/31/07 /s/ Leonard Osser September 13, 2002 --------------------------------------------- ----------------------- **Signature of Reporting Person Date See 18 U.S.C 1001 and 15 U.S.C. 78ff(a). Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure. Potential persons who are to respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB Number. Page 2