SCHEDULE 13G

(Rule 13d-102)

INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT TO RULES 13d-1 (b),

(c) AND (d) AND AMENDMENTS THERETO FILED PURSUANT TO 13d-2 (b)

(Amendment No. 2)*

(Name of Issuer)

(Title of Class of Securities)

(CUSIP Number)

(Date of Event Which Requires Filing of this Statement)

Check the appropriate box to designate the rule pursuant to which this Schedule is filed:

*The remainder of this cover page shall be filled out for a reporting person's initial filing on this form with respect to the subject class of securities, and for any subsequent amendment containing information which would alter the disclosures provided in a prior cover page.

The information required in the remainder of this cover page shall not be deemed to be "filed" for the purpose of Section 18 of the Securities Exchange Act of 1934 ("Act") or otherwise subject to the liabilities of that section of the Act but shall be subject to all other provisions of the Act (however, see the Notes).

(1) This Schedule 13G is filed by Skyline Expansion Fund, L.P., Skyline Expansion Fund Management, LLC, Skyline Venture Partners III, L.P., Skyline Venture Partners Qualified Purchaser Fund III, L.P., Skyline Venture Management III, LLC, John G. Freund and Yasunori Kaneko (collectively, the “Skyline Entities”).  The Skyline Entities expressly disclaim status as a “group” for purposes of this Schedule 13G.

(2)  Includes: (i) 34,486 shares held by Skyline Venture Partners III, L.P.; (ii) 1,385,182 shares held by Skyline Venture Partners Qualified Purchaser Fund III, L.P.; and (iii) 164,289 shares held by Skyline Expansion Fund, L.P.  Skyline Venture Management III, LLC is the sole general partner of Skyline Venture Partners Qualified Purchaser Fund III, L.P and Skyline Venture Partners III, L.P.  Skyline Venture Management III, LLC is also the managing member of Skyline Expansion Fund Management, LLC, which is the sole general partner of Skyline Expansion Fund, L.P.  John G. Freund and Yasunori Kaneko are managing directors of Skyline Venture Management III, LLC and share voting and dispositive power over the shares held by the Skyline Entities; however, they disclaim beneficial ownership of the shares held by these entities, except to the extent of their pecuniary interests therein.

(3)  This percentage is calculated based upon 30,127,041 shares of the Issuer’s common stock outstanding (as of October 31, 2010), as set forth in the Issuers most recent 10-Q, filed with the Securities and Exchange Commission on November 5, 2010.

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(1) This Schedule 13G is filed by Skyline Expansion Fund, L.P., Skyline Expansion Fund Management, LLC, Skyline Venture Partners III, L.P., Skyline Venture Partners Qualified Purchaser Fund III, L.P., Skyline Venture Management III, LLC, John G. Freund and Yasunori Kaneko (collectively, the “Skyline Entities”).  The Skyline Entities expressly disclaim status as a “group” for purposes of this Schedule 13G.

(2)  Includes: (i) 34,486 shares held by Skyline Venture Partners III, L.P.; (ii) 1,385,182 shares held by Skyline Venture Partners Qualified Purchaser Fund III, L.P.; and (iii) 164,289 shares held by Skyline Expansion Fund, L.P.  Skyline Venture Management III, LLC is the sole general partner of Skyline Venture Partners Qualified Purchaser Fund III, L.P and Skyline Venture Partners III, L.P.  Skyline Venture Management III, LLC is also the managing member of Skyline Expansion Fund Management, LLC, which is the sole general partner of Skyline Expansion Fund, L.P.  John G. Freund and Yasunori Kaneko are managing directors of Skyline Venture Management III, LLC and share voting and dispositive power over the shares held by the Skyline Entities; however, they disclaim beneficial ownership of the shares held by these entities, except to the extent of their pecuniary interests therein.

(3)  This percentage is calculated based upon 30,127,041 shares of the Issuer’s common stock outstanding (as of October 31, 2010), as set forth in the Issuers most recent 10-Q, filed with the Securities and Exchange Commission on November 5, 2010.

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(1) This Schedule 13G is filed by Skyline Expansion Fund, L.P., Skyline Expansion Fund Management, LLC, Skyline Venture Partners III, L.P., Skyline Venture Partners Qualified Purchaser Fund III, L.P., Skyline Venture Management III, LLC, John G. Freund and Yasunori Kaneko (collectively, the “Skyline Entities”).  The Skyline Entities expressly disclaim status as a “group” for purposes of this Schedule 13G.

(2)  Includes: (i) 34,486 shares held by Skyline Venture Partners III, L.P.; (ii) 1,385,182 shares held by Skyline Venture Partners Qualified Purchaser Fund III, L.P.; and (iii) 164,289 shares held by Skyline Expansion Fund, L.P.  Skyline Venture Management III, LLC is the sole general partner of Skyline Venture Partners Qualified Purchaser Fund III, L.P and Skyline Venture Partners III, L.P.  Skyline Venture Management III, LLC is also the managing member of Skyline Expansion Fund Management, LLC, which is the sole general partner of Skyline Expansion Fund, L.P.  John G. Freund and Yasunori Kaneko are managing directors of Skyline Venture Management III, LLC and share voting and dispositive power over the shares held by the Skyline Entities; however, they disclaim beneficial ownership of the shares held by these entities, except to the extent of their pecuniary interests therein.

(3)  This percentage is calculated based upon 30,127,041 shares of the Issuer’s common stock outstanding (as of October 31, 2010), as set forth in the Issuers most recent 10-Q, filed with the Securities and Exchange Commission on November 5, 2010.

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(1) This Schedule 13G is filed by Skyline Expansion Fund, L.P., Skyline Expansion Fund Management, LLC, Skyline Venture Partners III, L.P., Skyline Venture Partners Qualified Purchaser Fund III, L.P., Skyline Venture Management III, LLC, John G. Freund and Yasunori Kaneko (collectively, the “Skyline Entities”).  The Skyline Entities expressly disclaim status as a “group” for purposes of this Schedule 13G.

(2)  Includes: (i) 34,486 shares held by Skyline Venture Partners III, L.P.; (ii) 1,385,182 shares held by Skyline Venture Partners Qualified Purchaser Fund III, L.P.; and (iii) 164,289 shares held by Skyline Expansion Fund, L.P.  Skyline Venture Management III, LLC is the sole general partner of Skyline Venture Partners Qualified Purchaser Fund III, L.P and Skyline Venture Partners III, L.P.  Skyline Venture Management III, LLC is also the managing member of Skyline Expansion Fund Management, LLC, which is the sole general partner of Skyline Expansion Fund, L.P.  John G. Freund and Yasunori Kaneko are managing directors of Skyline Venture Management III, LLC and share voting and dispositive power over the shares held by the Skyline Entities; however, they disclaim beneficial ownership of the shares held by these entities, except to the extent of their pecuniary interests therein.

(3)  This percentage is calculated based upon 30,127,041 shares of the Issuer’s common stock outstanding (as of October 31, 2010), as set forth in the Issuers most recent 10-Q, filed with the Securities and Exchange Commission on November 5, 2010.

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(1) This Schedule 13G is filed by Skyline Expansion Fund, L.P., Skyline Expansion Fund Management, LLC, Skyline Venture Partners III, L.P., Skyline Venture Partners Qualified Purchaser Fund III, L.P., Skyline Venture Management III, LLC, John G. Freund and Yasunori Kaneko (collectively, the “Skyline Entities”).  The Skyline Entities expressly disclaim status as a “group” for purposes of this Schedule 13G.

(2)  Includes: (i) 34,486 shares held by Skyline Venture Partners III, L.P.; (ii) 1,385,182 shares held by Skyline Venture Partners Qualified Purchaser Fund III, L.P.; and (iii) 164,289 shares held by Skyline Expansion Fund, L.P.  Skyline Venture Management III, LLC is the sole general partner of Skyline Venture Partners Qualified Purchaser Fund III, L.P and Skyline Venture Partners III, L.P.  Skyline Venture Management III, LLC is also the managing member of Skyline Expansion Fund Management, LLC, which is the sole general partner of Skyline Expansion Fund, L.P.  John G. Freund and Yasunori Kaneko are managing directors of Skyline Venture Management III, LLC and share voting and dispositive power over the shares held by the Skyline Entities; however, they disclaim beneficial ownership of the shares held by these entities, except to the extent of their pecuniary interests therein.

(3)  This percentage is calculated based upon 30,127,041 shares of the Issuer’s common stock outstanding (as of October 31, 2010), as set forth in the Issuers most recent 10-Q, filed with the Securities and Exchange Commission on November 5, 2010.

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(1) This Schedule 13G is filed by Skyline Expansion Fund, L.P., Skyline Expansion Fund Management, LLC, Skyline Venture Partners III, L.P., Skyline Venture Partners Qualified Purchaser Fund III, L.P., Skyline Venture Management III, LLC, John G. Freund and Yasunori Kaneko (collectively, the “Skyline Entities”).  The Skyline Entities expressly disclaim status as a “group” for purposes of this Schedule 13G.

(2) Includes: (i) 1,963 shares held by John Freund Family Partnership IV, L.P.; and (ii) 21 shares held by John G. Freund Revocable Trust dtd 6/26/2001.

(3)  Includes: (i) 34,486 shares held by Skyline Venture Partners III, L.P.; (ii) 1,385,182 shares held by Skyline Venture Partners Qualified Purchaser Fund III, L.P.; and (iii) 164,289 shares held by Skyline Expansion Fund, L.P.  Skyline Venture Management III, LLC is the sole general partner of Skyline Venture Partners Qualified Purchaser Fund III, L.P and Skyline Venture Partners III, L.P.  Skyline Venture Management III, LLC is also the managing member of Skyline Expansion Fund Management, LLC, which is the sole general partner of Skyline Expansion Fund, L.P.  John G. Freund and Yasunori Kaneko are managing directors of Skyline Venture Management III, LLC and share voting and dispositive power over the shares held by the Skyline Entities; however, they disclaim beneficial ownership of the shares held by these entities, except to the extent of their pecuniary interests therein.

(4)  This percentage is calculated based upon 30,127,041 shares of the Issuer’s common stock outstanding (as of October 31, 2010), as set forth in the Issuers most recent 10-Q, filed with the Securities and Exchange Commission on November 5, 2010.

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(1) This Schedule 13G is filed by Skyline Expansion Fund, L.P., Skyline Expansion Fund Management, LLC, Skyline Venture Partners III, L.P., Skyline Venture Partners Qualified Purchaser Fund III, L.P., Skyline Venture Management III, LLC, John G. Freund and Yasunori Kaneko (collectively, the “Skyline Entities”).  The Skyline Entities expressly disclaim status as a “group” for purposes of this Schedule 13G.

(2)  Includes: (i) 34,486 shares held by Skyline Venture Partners III, L.P.; (ii) 1,385,182 shares held by Skyline Venture Partners Qualified Purchaser Fund III, L.P.; and (iii) 164,289 shares held by Skyline Expansion Fund, L.P.  Skyline Venture Management III, LLC is the sole general partner of Skyline Venture Partners Qualified Purchaser Fund III, L.P and Skyline Venture Partners III, L.P.  Skyline Venture Management III, LLC is also the managing member of Skyline Expansion Fund Management, LLC, which is the sole general partner of Skyline Expansion Fund, L.P.  John G. Freund and Yasunori Kaneko are managing directors of Skyline Venture Management III, LLC and share voting and dispositive power over the shares held by the Skyline Entities; however, they disclaim beneficial ownership of the shares held by these entities, except to the extent of their pecuniary interests therein.

(3)  This percentage is calculated based upon 30,127,041 shares of the Issuer’s common stock outstanding (as of October 31, 2010), as set forth in the Issuers most recent 10-Q, filed with the Securities and Exchange Commission on November 5, 2010.

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Signature

After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this Statement is true, complete and correct.

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EXHIBIT INDEX

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