PAGE 1
000 A000000 04/30/2011
000 C000000 0001275214
000 D000000 N
000 E000000 NF
000 F000000 Y
000 G000000 N
000 H000000 N
000 I000000 6.1
000 J000000 A
001 A000000 CALAMOS STRATEGIC TOTAL RETURN FUND
001 B000000 811-21484
001 C000000 6302457200
002 A000000 2020 CALAMOS COURT
002 B000000 NAPERVILLE
002 C000000 IL
002 D010000 60563
003 000000 N
004 000000 N
005 000000 N
006 000000 N
007 A000000 N
007 B000000 0
007 C010100 1
008 A000001 CALAMOS ADVISORS LLC
008 B000001 A
008 C000001 801-29688
008 D010001 NAPERVILLE
008 D020001 IL
008 D030001 60563
010 A000001 State Street Bank and Trust Company
010 B000001 028-00733
010 C010001 Boston
010 C020001 MA
010 C030001 02111
012 A000001 BANK OF NEW YORK (COMMON)
012 B000001 85-05006
012 C010001 NEW YORK
012 C020001 NY
012 C030001 10286
013 A000001 Deloitte & Touche LLP
013 B010001 Chicago
013 B020001 IL
013 B030001 60606
014 A000001 CALAMOS FINANCIAL SERVICES LLC
014 B000001 8-37854
015 A000001 STATE STREET BANK & TRUST COMPANY
015 B000001 C
015 C010001 BOSTON
015 C020001 MA
015 C030001 02111
015 E010001 X
PAGE 2
015 A000002 CITIBANK NA
015 B000002 S
015 C010002 SAO PAULO
015 D010002 BRAZIL
015 E040002 X
015 A000003 STANDARD CHARTERED BANK
015 B000003 S
015 C010003 KWUN TONG
015 D010003 HONG KONG
015 E040003 X
015 A000004 DEUTSCHE BANK, AG
015 B000004 S
015 C010004 PARIS
015 D010004 FRANCE
015 E040004 X
015 A000005 EUROCLEAR BANK
015 B000005 S
015 C010005 BRUSSELS
015 D010005 BELGIUM
015 E040005 X
015 A000006 CLEARSTREAM BANKING SA
015 B000006 S
015 C010006 LUXEMBOURG
015 D010006 LUXEMBOURG
015 E040006 X
015 A000007 DEUTSCHE BANK AG FRANKFURT
015 B000007 S
015 C010007 FRANKFURT
015 D010007 GERMANY
015 E040007 X
015 A000008 STANDARD CHARTERED BANK
015 B000008 S
015 C010008 Taiwan
015 D010008 Taiwan
015 E040008 X
018 000000 Y
019 A000000 Y
019 B000000 20
019 C000000 CALAMOSINV
020 A000001 BANK OF AMERICA
020 B000001 56-0906609
020 C000001 65
020 A000002 CREDIT SUISSE FIRST BOSTON
020 B000002 13-2853402
020 C000002 28
020 A000003 BARCLAYS GLOBAL INVESTORS SERVICES
020 B000003 94-3231066
020 C000003 23
020 A000004 BLOOMBERG TRADEBOOK LLC
020 B000004 13-388028
020 C000004 15
PAGE 3
020 A000005 CALYON SECURITIES
020 B000005 13-2602298
020 C000005 14
020 A000006 J.P. MORGAN SECURITIES INC.
020 B000006 13-3224016
020 C000006 11
020 A000007 INVESTMENT TECHNOLOGY GROUP, INC.
020 B000007 13-3757717
020 C000007 8
020 A000008 GOLDMAN SACHS & CO.
020 B000008 13-5108880
020 C000008 7
020 A000009 JEFFERIES & CO. INC.
020 B000009 95-2622900
020 C000009 6
020 A000010 BANK OF NEW YORK
020 B000010 13-3989198
020 C000010 5
021 000000 199
022 A000001 DEUTSCHE BANK SECURITIES, INC.
022 B000001 13-2730828
022 C000001 31102
022 D000001 28212
022 A000002 J.P. MORGAN SECURITIES INC.
022 B000002 13-3224016
022 C000002 17659
022 D000002 29952
022 A000003 BARCLAYS GLOBAL INVESTORS SERVICES
022 B000003 94-3231066
022 C000003 19096
022 D000003 25699
022 A000004 CREDIT SUISSE FIRST BOSTON
022 B000004 13-2853402
022 C000004 14169
022 D000004 20269
022 A000005 GOLDMAN SACHS & CO.
022 B000005 13-5108880
022 C000005 18154
022 D000005 2484
022 A000006 BANK OF NEW YORK
022 B000006 13-3989198
022 C000006 13752
022 D000006 513
022 A000007 BANK OF AMERICA
022 B000007 56-0906609
022 C000007 13523
022 D000007 0
022 A000008 BNP PARIBAS
022 B000008 13-1929559
022 C000008 70
022 D000008 12843
PAGE 4
022 A000009 CITIGROUP GLOBAL MARKETS, INC.
022 B000009 11-2418191
022 C000009 12693
022 D000009 0
022 A000010 JEFFERIES & CO. INC.
022 B000010 95-2622900
022 C000010 9178
022 D000010 0
023 C000000 402221
023 D000000 380826
024 000000 Y
025 A000001 BANK OF AMERICA
025 B000001 56-0906609
025 C000001 E
025 D000001 51032
025 A000002 DEUTSCHE BANK SECURITIES, INC.
025 B000002 13-2730828
025 C000002 E
025 D000002 12045
025 A000003 GOLDMAN SACHS & CO.
025 B000003 13-5108880
025 C000003 E
025 D000003 11245
025 A000004 CREDIT SUISSE FIRST BOSTON
025 B000004 13-2853402
025 C000004 E
025 D000004 10836
025 A000005 BARCLAYS GLOBAL INVESTORS SERVICES
025 B000005 94-3231066
025 C000005 E
025 D000005 12222
025 A000006 CITIGROUP GLOBAL MARKETS, INC.
025 B000006 11-2418191
025 C000006 E
025 D000006 7929
025 A000007 J.P. MORGAN SECURITIES INC.
025 B000007 13-3224016
025 C000007 E
025 D000007 27378
026 A000000 N
026 B000000 Y
026 C000000 N
026 D000000 Y
026 E000000 N
026 F000000 N
026 G010000 N
026 G020000 N
026 H000000 N
027 000000 N
028 A010000 0
028 A020000 0
PAGE 5
028 A030000 0
028 A040000 0
028 B010000 0
028 B020000 0
028 B030000 0
028 B040000 0
028 C010000 0
028 C020000 0
028 C030000 0
028 C040000 0
028 D010000 0
028 D020000 0
028 D030000 0
028 D040000 0
028 E010000 0
028 E020000 0
028 E030000 0
028 E040000 0
028 F010000 0
028 F020000 0
028 F030000 0
028 F040000 0
028 G010000 0
028 G020000 0
028 G030000 0
028 G040000 0
028 H000000 0
030 A000000 0
030 B000000 0.00
030 C000000 0.00
031 A000000 0
031 B000000 0
032 000000 0
033 000000 0
035 000000 0
036 B000000 0
038 000000 0
042 A000000 0
042 B000000 0
042 C000000 0
042 D000000 0
042 E000000 0
042 F000000 0
042 G000000 0
042 H000000 0
043 000000 0
044 000000 0
045 000000 Y
046 000000 N
047 000000 Y
048 000000 1.000
PAGE 6
048 A010000 0
048 A020000 0.000
048 B010000 0
048 B020000 0.000
048 C010000 0
048 C020000 0.000
048 D010000 0
048 D020000 0.000
048 E010000 0
048 E020000 0.000
048 F010000 0
048 F020000 0.000
048 G010000 0
048 G020000 0.000
048 H010000 0
048 H020000 0.000
048 I010000 0
048 I020000 0.000
048 J010000 0
048 J020000 0.000
048 K010000 0
048 K020000 0.000
049 000000 N
050 000000 N
051 000000 N
052 000000 N
053 A000000 N
054 A000000 Y
054 B000000 Y
054 C000000 N
054 D000000 N
054 E000000 N
054 F000000 N
054 G000000 N
054 H000000 Y
054 I000000 N
054 J000000 Y
054 K000000 N
054 L000000 N
054 M000000 Y
054 N000000 N
054 O000000 N
055 A000000 N
055 B000000 Y
056 000000 Y
057 000000 N
058 A000000 N
059 000000 Y
060 A000000 Y
060 B000000 Y
061 000000 0
PAGE 7
062 A000000 N
062 B000000 0.0
062 C000000 0.0
062 D000000 0.0
062 E000000 0.0
062 F000000 0.0
062 G000000 0.0
062 H000000 0.0
062 I000000 0.0
062 J000000 0.0
062 K000000 0.0
062 L000000 0.0
062 M000000 0.0
062 N000000 0.0
062 O000000 0.0
062 P000000 0.0
062 Q000000 0.0
062 R000000 0.0
063 A000000 0
063 B000000 0.0
066 A000000 Y
066 B000000 N
066 C000000 N
066 D000000 N
066 E000000 N
066 F000000 N
066 G000000 Y
067 000000 N
068 A000000 N
068 B000000 N
069 000000 N
070 A010000 Y
070 A020000 N
070 B010000 Y
070 B020000 Y
070 C010000 Y
070 C020000 N
070 D010000 Y
070 D020000 N
070 E010000 Y
070 E020000 N
070 F010000 Y
070 F020000 N
070 G010000 Y
070 G020000 N
070 H010000 Y
070 H020000 N
070 I010000 Y
070 I020000 N
070 J010000 Y
070 J020000 Y
PAGE 8
070 K010000 Y
070 K020000 Y
070 L010000 Y
070 L020000 Y
070 M010000 Y
070 M020000 Y
070 N010000 Y
070 N020000 Y
070 O010000 Y
070 O020000 Y
070 P010000 Y
070 P020000 N
070 Q010000 N
070 Q020000 N
070 R010000 Y
070 R020000 N
071 A000000 277918
071 B000000 218004
071 C000000 2130433
071 D000000 10
072 A000000 6
072 B000000 23943
072 C000000 24331
072 D000000 0
072 E000000 129
072 F000000 10953
072 G000000 0
072 H000000 0
072 I000000 14
072 J000000 60
072 K000000 0
072 L000000 106
072 M000000 64
072 N000000 68
072 O000000 0
072 P000000 5127
072 Q000000 184
072 R000000 60
072 S000000 45
072 T000000 0
072 U000000 0
072 V000000 0
072 W000000 67
072 X000000 16748
072 Y000000 0
072 Z000000 31655
072AA000000 0
072BB000000 33001
072CC010000 239380
072CC020000 0
072DD010000 48672
PAGE 9
072DD020000 0
072EE000000 0
073 A010000 0.3200
073 A020000 0.0000
073 B000000 0.0000
073 C000000 0.0000
074 A000000 0
074 B000000 0
074 C000000 18121
074 D000000 763160
074 E000000 184568
074 F000000 1293339
074 G000000 9377
074 H000000 0
074 I000000 81849
074 J000000 15064
074 K000000 0
074 L000000 15248
074 M000000 393
074 N000000 2381119
074 O000000 18600
074 P000000 2169
074 Q000000 566000
074 R010000 0
074 R020000 0
074 R030000 0
074 R040000 18020
074 S000000 0
074 T000000 1776330
074 U010000 154514
074 U020000 0
074 V010000 11.50
074 V020000 0.00
074 W000000 0.0000
074 X000000 111
074 Y000000 1072887
075 A000000 0
075 B000000 1672227
076 000000 9.96
077 A000000 N
078 000000 N
080 C000000 0
081 B000000 0
082 B000000 0
083 B000000 0
084 B000000 0
086 A010000 0
086 A020000 0
086 B010000 0
086 B020000 0
086 C010000 0
PAGE 10
086 C020000 0
086 D010000 0
086 D020000 0
086 E010000 0
086 E020000 0
086 F010000 0
086 F020000 0
087 A010000 COMMON STOCK
087 A020000 128125101
087 A030000 CSQ
088 A000000 N
088 B000000 N
088 C000000 Y
088 D000000 N
SIGNATURE CURTIS HOLLOWAY
TITLE TREASURER