================================================================================

                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549
                             ----------------------
                                            

                                   F O R M 6-K

           REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR
                15d-16 UNDER THE SECURITIES EXCHANGE ACT OF 1934

                         For the month of November 2004

                           Prana Biotechnology Limited
                              (Name of Registrant)


      Level 1, 100 Dorcas Street, South Melbourne, Victoria 3205 Australia
                     (Address of Principal Executive Office)

                  Indicate by check mark whether the registrant files or will 
file annual reports under cover of Form 20-F or Form 40-F.

                           Form 20-F   X    Form 40-F __         

                  Indicate by check mark if the registrant is submitting the 
Form 6-K in paper as permitted by Regulation S-T Rule 101(b)(1): ___

                  Indicate by check mark if the registrant is submitting the 
Form 6-K in paper as permitted by Regulation S-T Rule 101(b)(7): __

                  Indicate by check mark whether by furnishing the information
contained in this Form, the registrant is also thereby furnishing the
information to the Commission pursuant to Rule 12g3-2(b) under the Securities
Exchange Act of 1934.

                                   Yes __ No X

                  If "Yes" is marked, indicate below the file number assigned to
the registrant in connection with Rule 12g3-2(b): 82-_____________
                                                                  

This Form 6-K is being incorporated by reference into the Registrant's Form F-3
Registration Statement File No. 333-116232

================================================================================





                           PRANA BIOTECHNOLOGY LIMITED


6-K Items

1.   Prana  Biotechnology  Limited Proxy Statement for Annual Meeting to be held
     November 17, 2004.

2.   Prana Biotechnology Limited Form of Proxy Card.







                                                                          ITEM 1





                       [GRAPHIC OMITTED][GRAPHIC OMITTED]

                                    NOTICE OF
                             ANNUAL GENERAL MEETING

               Incorporating Explanatory Memorandum and Proxy Form

                                  To be held on
                  Wednesday 17 November 2004 at 10:30am at our
              offices, Level 2, 369 Royal Parade, Parkville, 3052.





                      [GRAPHIC OMITTED][GRAPHIC OMITTED]


                      Notice of 2004 Annual General Meeting
                      -------------------------------------

Notice is given  that the 2004  Annual  General  Meeting  of  Shareholders  (the
"Meeting")  of  Prana  Biotechnology  Limited  (the  "Company")  will be held at
10.30am on  Wednesday,  17  November,  2004 at our offices at Level 2, 369 Royal
Parade, Parkville, 3052.

BUSINESS
--------

2004 ANNUAL FINANCIAL STATEMENTS

To present  before the Meeting the Annual  Financial  Statements  of the Company
comprising the Annual Financial Report,  the Directors' Report and the Auditor's
Report.

RESOLUTIONS - ORDINARY BUSINESS
-------------------------------

To consider  and, if deemed  advisable,  to adopt the following  resolutions  as
ordinary resolutions with or without amendment:

Resolution 1: Re-Election of Mr. Geoffrey Kempler to Serve as a Director

"That Mr.  Geoffrey  Kempler,  a Director of the Company and the Chairman of the
Company's  Board of  Directors,  who  retires  by  rotation  from  office and is
eligible for re-election to the office of Director at the Meeting, be and hereby
is  re-elected  as a Director  of the  Company  for a term of up to three  years
expiring in 2007."

Resolution 2: Election of Dr. Jonas Alsenas to Serve as a Director

"That Dr. Jonas Alsenas,  who was appointed by the Company's  Board of Directors
as a Director of the Company  during the year  following the 2003 Annual General
Meeting of  Shareholders  as an additional  Director on the  Company's  Board of
Directors (as permitted  under the Company's  Constitution),  being eligible for
election as a Director of the Company and offering himself for election,  be and
hereby is elected as a Director of the Company for an unlimited  term so long as
he is the Company's Managing Director."

Resolution  3:  Approval  of  Previous  Issuance  of  Ordinary  Shares  to  P.N.
                Gerolymatos S.A.

"That  the  issuance  of  1,350,000  ordinary  shares  of the  Company  to  P.N.
Gerolymatos  S.A,  pursuant to and under the terms of the  Settlement  Agreement
dated 28 July,  2004,  between the Company,  P.N.  Gerolymatos  S.A. and certain
other parties, be and hereby is approved."

Resolution  4:  Approval  of Previous  Issuance  of  Ordinary  Shares to Certain
                Consultants

"That the issuance of  1,098,232  fully paid  ordinary  shares of the Company to
certain  consultants of the Company,  as described and under the terms set forth
in the  Explanatory  Memorandum  to the  Notice  of  Meeting,  be and  hereby is
approved."

Resolution 5: Approval of Previous Grants of Options to Certain Consultants

"That the grant of options to purchase 912,000 ordinary shares of the Company to
certain  consultants of the Company,  as described and under the terms set forth
in the  Explanatory  Memorandum to the Notice of Meeting,  exercisable at A$0.50
per ordinary share, be and hereby is approved."

Resolution 6: Approval of Previous Grants of Options to Certain Employees

"That,  the grants of options to certain  employees  of the  Company to purchase
20,000 ordinary shares of the Company,  exercisable at A$0.50 per ordinary share
on or before 30 June  2005,  under  the  terms and  conditions  set forth in the
Company's Employee and Consultant Option Plan 2000, be and hereby is approved."

--------------------------------------------------------------------------------
                                     Page 2



Resolution 7: Approval of Issuance of Warrants to Rodman & Renshaw, LLC

"That the issuance of warrants to purchase 320,000 American  Depositary Receipts
of the Company,  or ADRs, each  representing ten ordinary shares of the Company,
exercisable  at US$8.00  per ADR on or before 4 June  2009,  to Rodman & Renshaw
LLC, be and hereby is approved."

Resolution 8: Approval of Grant of Unlisted Options to Dr. Jonas Alsenas

"That,  subject to the approval of Resolution  10 with or without  amendment the
grant of  options  to  purchase  380,000  American  Depositary  Receipts  of the
Company,  or  ADRs,  each  representing  ten  ordinary  shares  of the  Company,
exercisable  at US$5.00 per ADR, under the terms and conditions set forth in the
Explanatory  Memorandum to the Notice of the Meeting,  to Dr. Jonas Alsenas,  in
his  capacity  as Chief  Executive  Officer  of the  Company,  be and  hereby is
approved.  Such options will be granted by the Company under and pursuant to the
terms of the 2004 ADS  Option  Plan,  subject  to the  adoption  thereof  at the
Meeting  (or under any other  option  plan duly  adopted  by a  majority  of the
non-employee  members of the Board of  Directors of the Company or a majority of
the  members of a  committee  of  non-employee  directors  established  for such
purpose)."

Resolution 9: Non-Executive Directors Remuneration Pool

"That,  the  aggregate  amount  available  per  annum  for the  remuneration  of
Non-Executive  Directors for their services (payable in cash, shares or options)
be  increased  by  AU$1,000,000,  from  AU$250,000  up to a  maximum  amount  of
AU$1,250,000 per annum."

Resolution 10: Adoption of the 2004 American Depositary Share (ADS) Option Plan

"That, the Company's 2004 American  Depositary Share (ADS) Option Plan (the "ADS
Plan"),  attached as Annexure A to the Explanatory  Memorandum  attached to this
Notice of Meeting, under which options to purchase American Depositary Shares of
the Company may be granted to employees, directors,  consultants and independent
contractors of the Company and its subsidiaries, as determined from time to time
by a  committee  of the Board of  Directors  of the  Company,  be and  hereby is
approved and adopted in all  respects.  Options  granted  under the ADS Plan are
exercisable at such exercise price and will have such term and other  conditions
as set forth in the ADS Plan."

Resolution 11: Adoption of the 2004 Employees, Directors' and Consultants' Share
               and Option Plan

"That,  the Company's  2004  Employees,  Directors' and  Consultants'  Share and
Option  Plan  (the  "ASX  Plan"),  attached  as  Annexure  B to the  Explanatory
Memorandum  attached to this Notice of Meeting,  under which ordinary shares may
be issued and options to purchase  ordinary  shares may be granted to employees,
directors and  consultants  of the Company and its  subsidiaries,  as determined
from time to time by a committee of the Board of  Directors  of the Company,  be
and hereby is approved and adopted in all  respects.  Options  granted under the
ASX Plan are  exercisable  at such  exercise  price  and will have such term and
other conditions as set forth in the ASX Plan."

Resolution  12:  Approval of Maximum  Shares  Issuable  under the 2004  American
                 Depositary  Share  (ADS)  Option  Plan and the 2004  Employees,
                 Directors'  and Consultants' Share and Option Plan

"That, subject to the approval of Resolution 10 with or without amendment and/or
subject to the approval of Resolution 11 with or without amendment,  the Company
is hereby authorised to issue up to an aggregate  12,000,000  ordinary shares of
the  Company  or  American  Depositary  Shares  of  the  Company,   representing
12,000,000  ordinary shares,  under and pursuant to the 2004 American Depositary
Share (ADS)  Option Plan and the 2004  Employees,  Directors'  and  Consultants'
Share and Option Plan."

Resolution 13: Approval of Grant of Unlisted Options to Mr. Geoffrey Kempler

"That, subject to the approval of Resolution 1 with or without amendment and the
approval  of  Resolution  11 with or without  amendment,  the  Company is hereby
authorised  to  grant to Mr.  Geoffrey  Kempler  unlisted  options  to  purchase
1,000,000  ordinary shares of the Company,  exercisable for nil consideration on
or before 30 June,  2010.  Such options will be granted by the Company under and
pursuant to the terms of the 2004  Employees',  Directors' & Consultants'  Share
and Option Plan,  subject to the  adoption  thereof at the Meeting (or under any
other option plan duly adopted by a majority of the non-employee  members of the
Board of Directors of the Company or a majority of the members of a committee of
non-employee  directors  established for such purpose).  Such options may not be
exercised  until and  unless  the price of the  Company's  ordinary  shares  has
achieved and  maintained a minimum value of $1.00 for five  consecutive  trading
days.  The  ordinary  shares  issued upon  exercise  of such  options may not be
disposed of without the prior consent of the Company's Board of Directors."

--------------------------------------------------------------------------------
                                     Page 3



Resolution 14: Approval of Grant of Unlisted Options to Prof. Colin Masters

"That,  subject to the approval of Resolution 11 with or without amendment,  the
Company  is hereby  authorised  to grant to  Professor  Colin  Masters  unlisted
options to purchase  1,000,000  ordinary shares of the Company,  exercisable for
nil  consideration  on or before 30 June,  2010. Such options will be granted by
the Company under and pursuant to the terms of the 2004 Employees', Directors' &
Consultants'  Share and  Option  Plan,  subject to the  adoption  thereof at the
Meeting  (or under any other  option  plan duly  adopted  by a  majority  of the
non-employee  members of the Board of  Directors of the Company or a majority of
the  members of a  committee  of  non-employee  directors  established  for such
purpose).  Such options may not be  exercised  until and unless the price of the
Company's  ordinary  shares has achieved and maintained a minimum value of $1.00
for five  consecutive  trading days. The ordinary shares issued upon exercise of
such options may not be disposed of without the prior  consent of the  Company's
Board of Directors."

Resolution 15: Approval of Grant of Unlisted Options to Mr. Brian Meltzer

"That, subject to the approval of Resolution 9 with or without amendment and the
approval  of  Resolution  11 with or without  amendment,  the  Company is hereby
authorised to grant to Mr. Brian Meltzer  unlisted  options to purchase  300,000
ordinary shares of the Company,  exercisable for nil  consideration on or before
30 June, 2010. Such options will be granted by the Company under and pursuant to
the terms of the 2004  Employees',  Directors' &  Consultants'  Share and Option
Plan,  subject to the adoption thereof at the Meeting (or under any other option
plan duly  adopted by a  majority  of the  non-employee  members of the Board of
Directors  of the  Company  or a  majority  of the  members  of a  committee  of
non-employee  directors  established for such purpose).  Such options may not be
exercised  until and  unless  the price of the  Company's  ordinary  shares  has
achieved and  maintained a minimum value of $1.00 for five  consecutive  trading
days.  The  ordinary  shares  issued upon  exercise  of such  options may not be
disposed of without the prior consent of the Company's Board of Directors."

Resolution 16: Approval of Grant of Unlisted Options to Dr. George Mihaly

"That, subject to the approval of Resolution 9 with or without amendment and the
approval  of  Resolution  11 with or without  amendment,  the  Company is hereby
authorised to grant to Dr. George Mihaly  unlisted  options to purchase  300,000
ordinary shares of the Company,  exercisable for nil  consideration on or before
30 June, 2010. Such options will be granted by the Company under and pursuant to
the terms of the 2004  Employees',  Directors' &  Consultants'  Share and Option
Plan,  subject to the adoption thereof at the Meeting (or under any other option
plan duly  adopted by a  majority  of the  non-employee  members of the Board of
Directors  of the  Company  or a  majority  of the  members  of a  committee  of
non-employee  directors  established for such purpose).  Such options may not be
exercised  until and  unless  the price of the  Company's  ordinary  shares  has
achieved and  maintained a minimum value of $1.00 for five  consecutive  trading
days.  The  ordinary  shares  issued upon  exercise  of such  options may not be
disposed of without the prior consent of the Company's Board of Directors."

Resolution 17:  Approval of Issuance of Ordinary  Shares to Mr. Brian Meltzer in
                Lieu of Director's Base Fees

"That, subject to the approval of Resolution 9 with or without amendment and the
approval  of  Resolution  11 with or without  amendment,  an annual base fee for
director services in an aggregate amount of AU$40,000 be paid by way of issuance
of fully paid ordinary shares of the Company to Mr. Brian Meltzer, a Director of
the Company. Such shares will be issued by the Company under and pursuant to the
terms of the 2004 Employees',  Directors' & Consultants'  Share and Option Plan,
subject to the  adoption  thereof at the  Meeting (or under any other share plan
duly adopted by a majority of the non-employee members of the Board of Directors
of the  Company or a majority  of the  members of a  committee  of  non-employee
directors established for such purpose).  The number of shares to be issued will
be calculated based on a price per ordinary share equal to the lesser of:
a)   80%  of  the  average  market  price  for  the  Company's  ordinary  shares
     calculated  over the five days prior to the Company's  2004 Annual  General
     Meeting of Shareholders, or;
b)   80%  of the  average  closing  price  for  the  Company's  ordinary  shares
     calculated  over the six months prior to the Company's  2004 Annual General
     Meeting of Shareholders."

Resolution 18:  Approval of Issuance of Ordinary  Shares to Dr. George Mihaly in
                Lieu of Director's Base Fees

"That, subject to the approval of Resolution 9 with or without amendment and the
approval  of  Resolution  11 with or without  amendment,  an annual base fee for
director services in an aggregate amount of AU$40,000 be paid by way of issuance
of fully paid ordinary shares of the Company to Dr. George Mihaly, a Director of
the  Company.  Such shares will be granted by the Company  under and pursuant to
the terms of the 2004  Employees',  Directors' &  Consultants'  Share and Option
Plan,  subject to the adoption  thereof at the Meeting (or under any other share
plan duly  adopted by a  majority  of the  non-employee  members of the Board of
Directors  of the  Company  or a  majority  of the  members  of a  committee  of
non-employee directors established for such purpose). The number of shares to be
issued  will be  calculated  based on a price per  ordinary  share  equal to the
lesser of:
a)   80%  of  the  average  market  price  for  the  Company's  ordinary  shares
     calculated  over the five days prior to the Company's  2004 Annual  General
     Meeting of Shareholders, or;
b)   80%  of the  average  closing  price  for  the  Company's  ordinary  shares
     calculated  over the six months prior to the Company's  2004 Annual General
     Meeting of Shareholders."

--------------------------------------------------------------------------------
                                     Page 4





Resolution 19: Approval of Issuance of Ordinary Shares to Prof. Colin Masters in
               Lieu of Director's Base Fees

"That,  subject to the approval of Resolution 11 with or without  amendment,  an
annual base fee for  director  services in an  aggregate  amount of AU$40,000 be
paid by way of  issuance of fully paid  ordinary  shares of the Company to Prof.
Colin  Masters,  a Director of the  Company.  Such shares will be granted by the
Company  under and  pursuant to the terms of the 2004  Employees',  Directors' &
Consultants'  Share and  Option  Plan,  subject to the  adoption  thereof at the
Meeting  (or under any  other  share  plan duly  adopted  by a  majority  of the
non-employee  members of the Board of  Directors of the Company or a majority of
the  members of a  committee  of  non-employee  directors  established  for such
purpose).  The number of shares to be issued will be calculated based on a price
per ordinary share equal to the lesser of:
a)   80%  of  the  average  market  price  for  the  Company's  ordinary  shares
     calculated  over the five days prior to the Company's  2004 Annual  General
     Meeting of Shareholders, or;
b)   80%  of the  average  closing  price  for  the  Company's  ordinary  shares
     calculated  over the six months prior to the Company's  2004 Annual General
     Meeting of Shareholders."

Date:  12 October 2004

By Order Of The Board

/s/Richard Revelins

Richard Revelins
Company Secretary

The  accompanying  Explanatory  Memorandum  and the  following  information  for
shareholders form part of this Notice of Meeting.

--------------------------------------------------------------------------------
                                     Page 5





                          INFORMATION FOR SHAREHOLDERS:

Voting Exclusion Statement
--------------------------

In accordance with the Australian  Stock Exchange,  or ASX, Listing Rule 14, the
Company will disregard votes cast: 

     a)   On resolution 3 by:
          o    P.N. Gerolymatos S.A., and
          o    An associate of that person/entity

     b)   On resolution 4 by
          o    Professor Ashley Bush, and
          o    The Anne McBride Company Inc., and
          o    Mr. David Bartash, and
          o    An associate of the above named person/entity

     c)   On resolution 5 by:
          o    Professor Ashley Bush, and
          o    Mr. Richard Revelins, and
          o    An associate of the above named person/entity

     d)   On resolution 6 by:
          o    Ms. Gaik Kok, and 
          o    Ms. Elisabeth Gautier, and
          o    Ms. Brenda Leung, and
          o    An associate of the above named person/entity

     e)   On resolution 7 by:
          o    Rodman & Renshaw, LLC, and
          o    An associate of that person/entity

     f)   On resolution 8 by:
          o    Dr. Jonas Alsenas, and
          o    An associate of that person/entity

     g)   On resolution 9 by:
          o    A Director of the Company
          o    An associate of that person/entity

     h)   On resolution 13 by:
          o    Mr. Geoffrey Kempler, and
          o    An associate of that person/entity

     i)   On resolution 14 and resolution 19 by:
          o    Professor Colin Masters, and
          o    An associate of that person/entity

     j)   On resolution 15 and resolution 17 by:
          o    Mr. Brian Meltzer; and
          o    An associate of that person/entity

     k)   On resolution 16 and resolution 18 by:
          o    Dr. George Mihaly; and
          o    An associate of that person/entity

However, the Company need not disregard a vote if:
     o    It is cast by a person as proxy for a person who is  entitled to vote,
          in accordance with the directions on the proxy form; or
     o    It is cast by the person  chairing  the  meeting as proxy for a person
          who is entitled to vote, in  accordance  with a direction on the proxy
          form to vote as the proxy decides.

--------------------------------------------------------------------------------
                                     Page 6





Proxy Instructions
------------------

A member who is entitled to vote at a meeting may appoint:

(a) one proxy if the member is only entitled to one vote; and

(b) one or two proxies if the member is entitled to more than one vote.

Where more than one proxy is appointed  each proxy may be appointed to represent
a specific proportion of the member's voting rights. If the appointment does not
specify the  proportion or number of votes each proxy may  exercise,  each proxy
may  exercise  half of the votes in which  case any  fraction  of votes  will be
disregarded.

The proxy form (and the power of  attorney  or other  authority,  if any,  under
which the proxy form is signed) or a copy or facsimile which appears on its face
to be an authentic copy of the proxy form (and proof of the power of attorney or
other  authority  satisfactory  to the  Directors)  must be lodged at or sent by
facsimile  transmission to the registered office of the Company at Suite 2, 1233
High Street,  Armadale,  Victoria,  3143, or facsimile +61 3 9824 8161, not less
than 48 hours  before the Meeting,  or adjourned  meeting as the case may be, at
which the individual named in the proxy form proposes to vote.

The proxy form must be signed by the member or his/her  attorney duly authorised
in writing  or, if the member is a  corporation,  in a manner  permitted  by the
Australian Corporations Act 2001. A proxy given by a foreign corporation must be
executed  in  accordance   with  the  laws  of  that   corporation's   place  of
incorporation.

The proxy may, but need not, be a member of the Company.

A proxy form is attached to this Notice.

Statement Regarding Undirected Proxies
--------------------------------------

As  disclosed  on the proxy  form it is the  intention  of the  Chairman  of the
Meeting to vote any undirected proxies in favour of all resolutions. Pursuant to
changes  to the ASX  Listing  Rules,  which  came into  effect  for  shareholder
meetings  held  after 1 January  2002,  the proxy  from is  required  to contain
certain  disclosures  regarding the voting intentions of the Chairman  regarding
undirected  proxies.  Shareholders are advised to read the proxy form carefully.
By marking the box at the top of the proxy form, proxy holders  acknowledge that
the Chairman  may exercise  your proxy even if he has an interest in the outcome
of the  resolution  and votes  cast by him other  than as proxy  holder  will be
disregarded  because of that interest.  If you do not mark the box at the top of
the proxy form or  alternatively  each  resolution  your proxy may be considered
invalid.

Corporate Representatives
-------------------------

Any  corporation  which is a member of the Company may authorise (by certificate
under  common  seal or other form of  execution  authorised  by the laws of that
corporation's place of incorporation, or in any other manner satisfactory to the
chairperson of the Meeting) a natural person to act as its representative at any
general meeting.

Voting Entitlement
------------------

For the  purposes  of the  Australian  Corporations  Act 2001  and  corporations
Regulations,  shareholders  entered on the  company's  Register of Members as at
5:00pm, 15 November 2004 are entitled to attend and vote at the meeting.

On a poll,  members  have one vote for every  fully paid  ordinary  share  held.
Holders of options are not entitled to vote.


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                                     Page 7





                           Prana Biotechnology Limited
                           ---------------------------
                               ABN 37 080 699 065

                             Explanatory Memorandum
                             ----------------------

This  Explanatory  Memorandum  dated 6 October,  2004,  has been issued by Prana
Biotechnology  Limited  ABN 37 080 699 065  (the  "Company").  This  Explanatory
Memorandum  forms part of and should be read in  conjunction  with the Notice of
2004 Annual General Meeting of the Company  scheduled to be held on 17 November,
2004,  to which  this  Explanatory  Memorandum  is  attached.  This  Explanatory
Memorandum  has been  prepared  to assist  shareholders  of the  Company  in the
consideration  of the resolutions  proposed in the Notice of 2004 Annual General
Meeting.

The Board of  Directors  of the Company  recommends  that  shareholders  vote in
favour of the  Resolutions  described in this  Explanatory  Memorandum.  Certain
Directors withhold their recommendation in regard to specific resolutions, where
the passing of the specific resolution may result in a benefit to that Director,
in accordance with the Australian  Stock Exchange,  or ASX,  Listing Rule 14, as
detailed in the Voting Exclusion Statement attached to the Notice of Meeting.

PRESENTATION OF 2004 ANNUAL FINANCIAL STATEMENTS

The 2004 Annual  Financial  Statements  of the Company  will be presented to the
shareholders at the Meeting, in accordance with the Australian  Corporations Act
2001.  Shareholders  will be given the opportunity to ask the Board of Directors
and a representative of the accounting firm that audited the Company's financial
statements questions in respect of the 2004 Annual Financial Statements.

RESOLUTIONS - ORDINARY BUSINESS

1. RE-ELECTION OF MR. GEOFFREY KEMPLER TO SERVE AS A DIRECTOR
   ----------------------------------------------------------

     At each Annual General  Meeting of the Company,  one third of the directors
     of the  Company  (except a Managing  Director)  must  retire from office by
     rotation,  in  accordance  with the  Company's  Constitution.  No  director
     (except a Managing  Director) shall retain office for a period in excess of
     three  years  without  submitting  himself or herself  for  re-election.  A
     director   who  retires  from  office  by  rotation  and  is  eligible  for
     re-election may offer him or herself for re-election.

     Mr. Kempler has served as Chairman of the Board of Directors of the Company
     since November 11, 1997, and was last  re-elected to serve as a director of
     the Company at the Company's  2001 Annual General  Meeting of  shareholders
     held on November 16, 2001. Accordingly, Mr. Kempler must retire from office
     as a director and may stand for  re-election  to serve as a director at the
     Meeting.

     Mr  Kempler,  aged 49, is one of the  founders  of the Company and has been
     primarily  responsible  for the  successful  negotiation  of the  Company's
     existing contractual relationships with Massachusetts General Hospital, the
     University of Melbourne and the Biomolecular  Research  Institute.  Between
     November  1997 and August  2004  served as the  Company's  Chief  Executive
     Officer.  Mr Kempler is a qualified  industrial  psychologist and the major
     shareholder of Prana Biotechnology Limited.

2. ELECTION OF DR. JONAS ALSENAS TO SERVE AS A DIRECTOR
   ----------------------------------------------------

     In accordance  with the Company's  Constitution,  the Board of Directors of
     the  Company  may  appoint  any person to be a  director,  either to fill a
     vacancy or as an  additional  director  (provided  that the total number of
     directors does not exceed the maximum  allowed by law), and any director so
     appointed  may hold office only until the next  annual  general  meeting of
     shareholders when he or she shall be eligible for election.

     On March 25, 2004,  Dr.  Alsenas,  aged 43, was  appointed by the Company's
     Board of Directors to serve as a Director of the Company.  Dr.  Alsenas was
     appointed  Chief  Executive  Officer  of the  Company  on August  9,  2004.
     Accordingly, the shareholders are being asked at the Meeting to approve the
     election  of Dr.  Alsenas  to serve as a  Director  of the  Company  for an
     unlimited term so long as he is the Company's Managing Director.

     Prior to joining the Company, Dr. Alsenas was a leading U.S.  biotechnology
     and  pharmaceutical  company analyst.  Dr. Alsenas is a member of the Audit
     Risk and  Compliance  Committee.  Until December 2003, Dr Alsenas served as
     Managing Director (Research  Analyst/Portfolio  Manager), of ING Investment
     Management, New York, where he co-managed a hedge

                                     
--------------------------------------------------------------------------------
                                     Page 8





     fund with an  emphasis on  investments  in  biotechnology.  From April 1996
     through  June 2000,  Dr.  Alsenas was  Principal  and  ultimately  Managing
     Director as a research analyst at the investment  banking firm Furman Selz,
     LLC and its successor ING Barings, LLC, where he provided research coverage
     of the  biotechnology  sector.  Dr  Alsenas  began his  career in 1991 with
     Scheer & Company  in  Branford,  Connecticut  where he  provided  strategic
     consulting and due diligence for biotechnology and pharmaceutical  industry
     clients and  investors,  including  venture  capital  groups and  portfolio
     managers.  Dr Alsenas received a Doctor of Veterinary  Medicine degree from
     the  Ohio  State  University  and a  Bachelor  of  Arts  from  Northwestern
     University.

APPROVAL OF PREVIOUS ISSUANCE OF ORDINARY SHARES AND GRANTS OF OPTIONS

     According to Chapter 7.1 of the ASX Listing Rules, an entity must not issue
     or agree to issue equity  securities  exceeding 15% of the share capital of
     the Company  within a 12 month period.  The Company is seeking  shareholder
     approval  of the  issuance  of  ordinary  shares  and  grants of options to
     purchase  ordinary  shares to certain  person and entities in order to have
     the  flexibility  to issue up to 15% of the  Company's  share  capital in a
     rolling  12 month  period.  Resolutions  3, 4, 5 and 6 relate  to  previous
     issuances of equity.

3. APPROVAL OF PREVIOUS ISSUANCE OF ORDINARY SHARES TO P.N. GEROLYMATOS S.A.
   -------------------------------------------------------------------------

     On 28 July,  2004,  the  Company and The General  Hospital  Corporation  of
     Massachusetts  settled an on-going  litigation with P.N.  Gerolymatos  S.A.
     regarding the exploitation  rights to certain  patents.  Under the terms of
     the  settlement  agreement,  among other  things,  the Company  issued on 9
     August 2004 to P.N.  Gerolymatos S.A.  1,350,000 fully paid ordinary shares
     of the Company,  which are being held in escrow until 9 August, 2005 (being
     12 months from the date of issue).

4. APPROVAL OF PREVIOUS ISSUANCE OF ORDINARY SHARES TO CERTAIN CONSULTANTS
   -----------------------------------------------------------------------

     a)   The Company was originally  established  to develop and  commercialize
          Prof.  Bush's findings that the toxicity  associated with  Alzheimer's
          disease is due to aberrant  behaviour  by metals in the brain,  namely
          zinc and copper, binding to proteins.  Prof. Bush has been an integral
          part of the Company since it was founded in 1997. His demonstration of
          a long-term  commitment to the Company,  in addition to the successful
          clinical  trial of our first compound for the treatment of Alzheimer's
          disease,   reinforces   the   Company's   belief  that  Prof.   Bush's
          contribution  to the  Company is  essential  in its mission to develop
          therapeutic drugs designed to treat this malignant condition.

         On February 25, 2004, the Company  announced that it had entered into a
         new  consultancy  agreement  with  Professor  Ashley  Bush MD,  PhD, of
         Harvard  Medical  School,  under which Prof. Bush agreed to provide the
         Company  with  consulting  services  for a  period  of  ten  years.  In
         consideration  of his services,  we agreed to pay Prof.  Bush an annual
         consulting  fee of US$100,000.  Prof.  Bush is also entitled to receive
         1,650,000  ordinary  shares and  options to purchase  824,000  ordinary
         shares  at an  exercise  price  $0.50 per  share,  over the life of the
         contract.

         On 10 May, 2004,  pursuant to the new contract with Prof.  Ashley Bush,
         the Company  issued to Prof.  Ashley Bush 825,000  fully paid  ordinary
         shares of the Company.

     b)   On 20 February,  2004,  the Company issued 155,502 fully paid ordinary
          shares of the  Company to The Anne  McBride  Company  Inc.  in lieu of
          US$65,000 corporate advisory fees.

     c)   The  Company,  prior to its  listing  on the NASDAQ  SmallCap  Market,
          engaged Mr. David Bartash to provide to it U.S.  corporate  advice. In
          accordance with the agreement entered into between the Company and Mr.
          Bartash for these services,  Mr. Bartash has received  ordinary shares
          of the  Company  in lieu of cash  remuneration  bi-annually  (for  the
          periods of April  15-October  15 and October 15 -April 15). The number
          of ordinary  shares  issued to Mr.  Bartash  under such  agreement  is
          calculated according to the exchange rate and the closing price of the
          Company's  ordinary shares on the ASX on the day commencing the period
          of the service.

         In accordance with its agreement with Mr.  Bartash,  the Company issued
         to Mr.  Bartash,  (i) on 12 January,  2004,  67,955 fully paid ordinary
         shares in lieu of US$30,000  corporate  advisory fees for the period of
         15 October, 2003 through 15 April, 2004; and (ii) on 16 September 2004,
         49,755  fully  paid  ordinary  shares  in lieu of  US$30,000  corporate
         advisory  fees for the period of 15 April,  2004  through  15  October,
         2004.  The  difference in the amount of ordinary  shares issued in each
         tranche is due to share price  fluctuations  and US$-AU$  exchange rate
         fluctuations.

          Both The Anne  McBride  Company  Inc.  and Mr  David  Bartash  provide
          corporate  advice to the Company in relation to its  operations in the
          United  States.  The Company  believes that in addition to providing a
          valuable  service to the Company,  the  willingness of the above named
          consultants to forgo monetary  compensation  for their services and in
          lieu thereof,  to receive equity in the Company,  is beneficial to the
          Company.


--------------------------------------------------------------------------------
                                     Page 9






5. APPROVAL OF PREVIOUS GRANTS OF OPTIONS TO CERTAIN CONSULTANTS
   -------------------------------------------------------------

     a)   On 10 May, 2004, the Company  granted to Prof.  Ashley Bush options to
          purchase  412,000  ordinary  shares of the  Company,  pursuant  to the
          agreement  we entered  into with Prof.  Ashley Bush  described in Note
          4(a) of this Explanatory  Memorandum.  Such options are exercisable at
          $0.50 per ordinary share on or before February 1, 2007.

     b)   On 27 November,  2003,  the Company  granted to Mr.  Richard  Revelins
          options to purchase  500,000 ordinary shares of the Company in lieu of
          fees for services provided by him to the Company as Company Secretary.
          To date,  Mr.  Revelins has not  received  cash  compensation  for the
          invaluable  services he has provided to the Company.  Such options are
          exercisable  at $0.50 per ordinary share on or before 30 June 2005 and
          were granted under the Company's  Employee and Consultant  Option Plan
          2000.

6. APPROVAL OF PREVIOUS GRANTS OF OPTIONS TO CERTAIN EMPLOYEES
   -----------------------------------------------------------

     On 5 December,  2003, the Company granted to certain scientists employed by
     the Company options to purchase an aggregate  20,000 ordinary shares of the
     Company.  These  options  were issued as an  additional  incentive  to such
     scientists, in accordance with the Company Policy for recruiting, retaining
     and rewarding  valuable human resources.  These options were granted to the
     following employed scientists in the following amounts:

           Elisabeth Gautier:        options to purchase 5,000 ordinary shares
           Brenda Leung:             options to purchase 5,000 ordinary shares
           Gaik Kok:                 options to purchase 10,000 ordinary shares

     Such options are  exercisable  at $0.50 per ordinary  share on or before 30
     June 2005 and were granted under the Employee and  Consultants  Option Plan
     2000.

APPROVAL OF ISSUANCE OF ORDINARY SHARES AND GRANTS OF OPTIONS

7. APPROVAL OF ISSUANCE OF WARRANTS TO RODMAN & RENSHAW, LLC
   ---------------------------------------------------------

     At the general meeting of shareholders  held on June 1, 2004,  shareholders
     of the  Company  approved  a  private  placement  in the  United  States of
     4,000,000  American  Depositary  Receipts,  or ADRs, to  institutional  and
     professional  investors  at a price of US$5.00  per ADR,  for an  aggregate
     US$20 million.  The private  placement also involved the acquisition by the
     investors of five-year warrants to purchase an additional 3,000,000 ADRs at
     an exercise price of US$8.00 per ADR. Should these warrants be exercised in
     full, we would raise an additional US$24 million.

     Rodman  &  Renshaw,  LLC  acted  as the  placement  agent  for the  private
     placement  and  part of its fee was to  receive  warrants  to  purchase  an
     additional  320,000  ADRs,  each  representing  ten ordinary  shares of the
     Company,  exercisable  at a price of  US$8.00  per ADR on or before 4 June,
     2009.  The approval of the  issuance of such  warrants to Rodman & Renshaw,
     LLC was  omitted  in error from the  shareholder  approval  of the  private
     placement  transaction.  Accordingly,  the  Company is seeking  shareholder
     approval of the issuance of such warrants to Rodman & Renshaw, LLC.

8. APPROVAL OF GRANT OF UNLISTED OPTIONS TO DR. JONAS ALSENAS
   ----------------------------------------------------------

     The Company is seeking shareholder approval, in accordance with ASX Listing
     Rule 10.14,  to grant Dr. Jonas Alsenas  options to purchase  380,000 ADRs,
     each  representing  ten ordinary  shares of the Company,  exercisable  at a
     price of  US$5.00  per ADR.  Such  options  will vest over a period of four
     years, 25% at the end of each year from the date of grant. The options will
     expire at the end of eight years from date of grant.  Such  options will be
     granted  by the  Company  under and  pursuant  to the terms of the 2004 ADS
     Option  Plan,  subject to its  adoption  at the Meeting (or under any other
     option plan duly adopted by a majority of the  non-employee  members of the
     Board of  Directors  of the  Company  or a  majority  of the  members  of a
     committee of  non-employee  directors  established  for such  purpose).  If
     approved by the  shareholders at the Meeting,  such options will be granted
     to Dr. Alsenas  within one month from the date of the Meeting.  This option
     grant forms part of the  employment  agreement  entered into by the Company
     with Dr.  Alsenas,  under  which Dr.  Alsenas  agreed to serve as our Chief
     Executive  Officer as of such date.  Dr.  Alsenas agreed to devote his best
     efforts and full business time and attention to the  performance of service
     to the Company.

     As a  consequence  of his  interest  in  Resolution  8, Dr.  Jonas  Alsenas
     absented himself from the discussion of the Board of Directors with respect
     to,  and did not  vote in  respect  of,  the  proposal  to  present  to the
     Company's  shareholders  Resolution  8 or  the  accompanying  part  of  the
     Explanatory  Memorandum.  Mr. Kempler,  Prof. Masters,  Mr. Meltzer and Dr.
     Mihaly recommend that  shareholders vote in favour of Resolution 8 in order
     to enable  the  Company to  continue  to benefit  from Dr.  Jonas  Alsenas'
     expertise.

--------------------------------------------------------------------------------
                                    Page 10



9. NON-EXECUTIVE DIRECTORS REMUNERATION POOL
   -----------------------------------------

     The  Company is seeking  shareholder  approval to  increase  the  aggregate
     amount available per annum for the remuneration of non-executive  directors
     for  their  services  (payable  in cash,  ordinary  shares or  options)  by
     AU$1,000,000, from AU$250,000 to AU$1,250,000, for the following reasons:

     a)   New corporate governance  recommendations & requirements in connection
          with  the  ASX's  Principles  of  Good  Corporate  Governance  and the
          Sarbanes-Oxley  Act of 2002 (in  respect  of our NASDAQ  Stock  Market
          listing),  require  the  Company  to have a majority  of  independent,
          non-executive  directors,  some of whom  must have  special  financial
          expertise, before 1 July 2005; and

     b)   The Company,  now being a global company,  has opened  subsidiaries in
          the United States and the United  Kingdom,  recognising the importance
          of  a  local  presence  in  these  markets  to  further   develop  and
          commercialise  its  interests.  In light of the forgoing,  the Company
          would like to allow itself the  opportunity and ability to appoint new
          non-executive  directors to the Company with local  knowledge of these
          markets, and thus add value to the Company.

     This  proposal to increase the aggregate  amount of fees  available for the
     remuneration  of  non-executive  directors  (payable  in  cash,  shares  or
     options)  will enable the Company  during the next year to maintain a level
     of remuneration of its  non-executive  directors that is competitive and in
     line with international market conditions and industry standards. This will
     ensure  that the  Company  continues  to be able to attract and retain high
     calibre non-executive  directors.  It will also give the Company's Board of
     Directors  the  flexibility  to  introduce  two or more  new  non-executive
     directors, if that is considered desirable. Under the current non-executive
     director  remuneration  limit,  the  Board of  Directors  does not have the
     ability to take such steps.

     Mr.  Geoffrey  Kempler,  Dr.  Jonas  Alsenas and  Professor  Colin  Masters
     approved  the Board of  Directors  proposal to present to the  shareholders
     Resolution 9 and this accompanying part of this Explanatory Memorandum.  As
     a consequence  of their interest in Resolution 9, Mr. Brian Meltzer and Dr.
     George Mihaly absented  themselves from the discussion with respect to, and
     did not vote in respect  of, the  proposal  to present to the  shareholders
     Resolution 9 or this accompanying part of this Explanatory Memorandum.  Mr.
     Geoffrey  Kempler,  Dr. Jonas Alsenas and Professor Colin Masters recommend
     that the shareholders vote in favour of Resolution 9 in order to enable the
     Company to attract, retain and duly reward high calibre Directors.

10, 11,
& 12  ADOPTION  OF THE 2004  AMERICAN  DEPOSITARY  SHARE  (ADS) OPTION  PLAN 
      -----------------------------------------------------------------------
      AND THE  2004  EMPLOYEES,DIRECTORS' AND CONSULTANTS' SHARE AND OPTION PLAN
      --------------------------------------------------------------------------

     The Company is seeking  shareholder  approval to adopt the 2004 Employees',
     Directors' and Consultants' Share and Option Plan (the "2004 ASX Plan") and
     the 2004 American  Depository Share (ADS) Option Plan (the "2004 ADS Plan";
     and together with the 2004 ASX Plan, the "2004 Plans").  Under the 2004 ASX
     Plan,  the Company may issue  ordinary  shares of the Company traded on the
     Australian  Stock  Exchange,  and under the 2004 ADS Plan the  Company  may
     issue American  Depository  Shares ("ADSs") of the Company  reported on the
     NASDAQ SmallCap Market.  The Board of Directors  believes that the approval
     of the 2004 Plans by the shareholders is essential to allow the Company and
     its  subsidiaries  to be able to continue to attract,  motivate  and retain
     valuable  human  capital,  whose  present and  potential  contribution  are
     important to the Company's interests, development and success.

     In addition, shareholders are being asked to authorise the Company to issue
     under the 2004 Plans up to an aggregate  12,000,000 ordinary shares or ADSs
     representing  12,000,000  ordinary  shares.  Any  increase in such  maximum
     number of ordinary  shares or ADSs issuable under the 2004 Plans is subject
     to shareholder approval.

     According to ASX Listing Rule 10.14,  any issue of securities to a director
     of  the  Company  is  subject  to  shareholder  approval  at a  meeting  of
     shareholders;  the director and his/her associates are excluded from voting
     in regards to such resolutions. As such, the Company is seeking shareholder
     approval in Resolutions 8, 13-19 to issue securities under the Plans.

     THE 2004 ADS PLAN
     -----------------

     The Company is seeking shareholder approval to adopt the Company's 2004 ADS
     Plan,  a copy of which is  attached  hereto as  Annexure A and the terms of
     which are incorporated by reference into this Explanatory  Memorandum.  The
     adoption  of the  2004  ADS Plan was  approved  by the  Company's  Board of
     Directors,  including all of the non-employee directors. The purpose of the
     2004  ADS  Plan  is to  promote  the  interests  of  the  Company  and  its
     non-Australian   based  employees,   officers,   consultants,   independent
     contractors and directors.  The Board of Directors believe that an American
     Depositary  Share option plan is presently  required due to the appointment
     of Mr. Jonas Alsenas, a U.S.-based director,  as Chief Executive Officer of
     the Company, and the recent  establishment of a wholly-owned  subsidiary in
     the United States.


--------------------------------------------------------------------------------
                                    Page 11








     Options granted under the 2004 ADS Plan may be incentive stock options,  as
     provided in Section 422 of the Internal  Revenue Code of 1986,  as amended,
     or the Code, or  non-qualified  stock options.  Incentive stock options may
     only  be  granted  to  employees  of  the  Company  and  its   subsidiaries
     (including,  without  limitation,  officers  and  directors  who  are  also
     employees  of the Company and its  subsidiaries)  and may not be granted to
     any owner of 10% or more of the total combined  voting power of all classes
     of stock of the  Company  and its  subsidiaries,  or a 10%  Holder.  To the
     extent that the aggregate fair market value, determined on the date that an
     option is granted,  of ADSs with respect to which  incentive  stock options
     are  exercisable for the first time by an optionee during any calendar year
     exceeds  $100,000,  such option shall be treated as a  non-qualified  stock
     option.

     Under  the  2004  ADS  Plan,  the  Company  will be  entitled  to  grant to
     employees, officers, consultants,  independent contractors and directors of
     the  Company  or any of its  subsidiaries,  from time to time,  options  to
     purchase up to an aggregate  1,200,000 American Depositary Shares, or ADSs,
     of the  Company,  representing  12,000,000  ordinary  shares of the Company
     (which  constitute  approximately  10% of the issued and outstanding  share
     capital of the Company as of the date of this Explanatory Memorandum and is
     subject to adjustment as provided in the 2004 ADS Plan). The number of ADSs
     with respect to which options may be granted to any employee under the 2004
     ADS Plan in any calendar year shall not exceed  500,000 ADSs,  representing
     5,000,000 ordinary shares of the Company. ADSs that are forfeited under the
     terms of the 2004 ADS Plan and ADSs that are the  subject of  options  that
     expire  unexercised  or which  are  otherwise  surrendered  by an  optionee
     without  receiving  any payment or other  benefit with respect  thereto may
     again become available for new option grants under the 2004 ADS Plan.

     The 2004 ADS Plan will be administered by a committee  comprised of members
     of the Board of Directors of the Company,  or the Committee.  The Committee
     will have  authority,  in its sole  discretion,  to grant options under the
     2004 ADS Plan,  to  interpret  the  provisions  of the 2004 ADS Plan and to
     prescribe,  amend,  and rescind rules and regulations  relating to the 2004
     ADS Plan or any options  granted  thereunder  as it may deem  necessary  or
     advisable.  All decisions made by the Committee  pursuant to the provisions
     of the 2004 ADS Plan shall be final, conclusive and binding on all persons.

     The type of option (incentive stock option or non-qualified  stock option),
     exercise price,  option term and vesting  schedule of options granted under
     the 2004 ADS Plan are determined by the Committee,  in accordance  with the
     provisions  of the ADS Plan,  and  specified in an option  agreement by and
     between the Company and the optionee,  subject to the terms of the 2004 ADS
     Plan.  The exercise  price per each ADS will be determined by the Committee
     at the time  any  option  is  granted,  however  the  exercise  price of an
     incentive  stock option will not be less than 100% of the fair market value
     of such ADS on the date of the grant and the  price of an  incentive  stock
     option  granted  to a 10%  Holder  will not be less  than  110% of the fair
     market value of such ADS on the date of the grant.  Options  granted  under
     the 2004 ADS Plan will not be exercisable after the expiration of ten years
     from  the  date of  grant,  and in the case of an  incentive  stock  option
     granted to a 10% Holder, the term of the option will be five years from the
     date  of  grant  or such  shorter  term as may be  provided  in the  option
     agreement.  The  options  will vest over a four year  period in four  equal
     installments,  25% at the end of each year  from the date of grant,  unless
     otherwise provided by the Committee in an option agreement.

     Options  granted under the 2004 ADS Plan are not assignable or transferable
     by the grantee, other than by will or the laws of descent and distribution,
     and may be exercised during the lifetime of the grantee only by the grantee
     or his guardian or legal representative

     THE 2004 ASX Plan 
     ----------------- 

     The Company is seeking  shareholder  approval to adopt the  Company's  2004
     Employees',  Directors' & Consultants' Share & Option Plan, or the 2004 ASX
     Plan,  a copy of which is  attached  hereto as  Annexure B and the terms of
     which are incorporated by reference into this Explanatory  Memorandum.  The
     adoption  of the  2004  ASX Plan was  approved  by the  Company's  Board of
     Directors,  including all of the non-employee directors. Under the 2004 ASX
     Plan,  the Company will be entitled to issue to  employees,  directors  and
     consultants of the Company and its  subsidiaries,  from time to time, up to
     and aggregate  amount of 12,000,000  ordinary  shares of the Company (which
     constitute approximately 10% of the issued and outstanding share capital of
     the Company as of the date of this Explanatory Memorandum and is subject to
     adjustment  as  provided in the 2004 ASX Plan),  either by the  issuance of
     ordinary shares or under options to purchase  ordinary shares granted under
     the 2004 ASX Plan.

     The 2004 ASX Plan will be administered by a committee  comprised of members
     of the Board of Directors of the Company,  or the Committee.  The Committee
     will have  authority,  in its sole  discretion,  to grant options under the
     2004 ASX Plan,  to  interpret  the  provisions  of the 2004 ASX Plan and to
     prescribe,  amend,  and rescind rules and regulations  relating to the 2004
     ASX Plan or any  issue  or grant  thereunder  as it may deem  necessary  or
     advisable.  All decisions made by the Committee  pursuant to the provisions
     of the 2004 ASX Plan shall be final, conclusive and binding on all persons.

     The number of shares  issued or options  granted,  the  exercise  price and
     option term or options granted,  the vesting schedule and escrow periods of
     shares issued and options  granted,  under the 2004 ASX Plan are determined
     by the  Committee,  in accordance  with the provisions of the ASX Plan, and
     specified  in an  offer  document  from the  Company  and  accepted  by the
     eligible person, subject to the terms of the 2004 ASX Plan. Options granted
     under the 2004 ASX Plan will

--------------------------------------------------------------------------------
                                     Page 12





     be unlisted and  exercisable at an exercise price equal to less than market
     value of an ordinary share on the ASX at the date of grant, as set forth in
     the 2004  ASX  Plan,  or such  other  exercise  price  that  the  Committee
     determines to be appropriate under the circumstances. The term of an option
     granted  under  the 2004  ASX Plan  will be  determined  by the  Committee,
     however no option will be  exercisable  after the  expiration  of ten years
     from the date of its grant.  Except as  otherwise  provided in the 2004 ASX
     Plan or determined by the Committee and set forth in an offer document, the
     issuance of shares and exercise of options  granted under the 2004 ASX Plan
     will either (i) be subject to an escrow, under which such shares or options
     cannot be disposed of or  exercised,  respectively,  within six months from
     the  date of issue or  grant  (or 12  months  if  issued  or  granted  to a
     director);  or (ii)  will  vest  over a four  year  period  in  four  equal
     installments,  25% at the end of each year  from the date of grant.  Shares
     issued and options  granted under the 2004 ASX Plan may be subject to other
     performance criteria and hurdles, as determined by the Committee.

     The Board of  Directors  of the Company  believes  that the adoption of the
     2004 ASX Plan is necessary for the Company in order to:
     a)   provide  eligible  persons  with an  additional  incentive  to work to
          improve the performance of the Company;
     b)   attract and retain eligible persons essential for the continued growth
          and development of the Company;
     c)   promote and foster loyalty and support  amongst  eligible  persons for
          the benefit of the Company;  
     d)   enhance the relationship  between the Company and eligible persons for
          the long term mutual benefit of all parties; and
     e)   provide an alternative to cash payments.

13, 14,
15, 16   APPROVAL OF GRANT OF UNLISTED OPTIONS TO DIRECTORS
         --------------------------------------------------

     In  recognition  of the Board of  Directors'  future  contributions  to the
     growth and success of the Company, the Company seeks shareholder  approval,
     in accordance  with ASX Listing Rule 10.14,  to issue to its directors,  in
     their capacity as such, unlisted options to purchase ordinary shares of the
     Company,  exercisable for nil  consideration  on or before 30 June 2010, as
     set forth  below.  Such  options  will be granted by the Company  under and
     pursuant to the terms of the 2004  Employees',  Directors'  &  Consultants'
     Share & Option  Plan,  subject to its adoption at the Meeting (or under any
     other option plan duly adopted by a majority of the non-employee members of
     the Board of  Directors  of the  Company or a majority  of the members of a
     committee of non-employee directors established for such purpose).
                                
--------------------------------------------------------------------------------
Name                            Position                       Amount of Options
--------------------------------------------------------------------------------
Mr. Geoffrey Kempler            Executive Chairman                1,000,000
--------------------------------------------------------------------------------
Professor Colin Masters         Executive Director                1,000,000
--------------------------------------------------------------------------------
Mr. Brian Meltzer               Non-Executive Director              300,000
--------------------------------------------------------------------------------
Dr. George Mihaly               Non-Executive Director              300,000
--------------------------------------------------------------------------------
Total                                                             2,600,000
--------------------------------------------------------------------------------

     The above  options  will be held in escrow for one year from date of grant.
     In addition,  the vesting  terms of these  option  grants will provide that
     these  options  may not be  exercised  until  and  unless  the price of the
     Company's  ordinary  shares has achieved and  maintained a minimum value of
     $1.00 for five consecutive trading days.  Further,  under the terms of this
     option grant, the directors will not be entitled to dispose of the ordinary
     shares  issued to them upon  exercise  of these  options  without the prior
     consent  of  the  Company's   Board  of  Directors.   If  approved  by  the
     shareholders, such options will be granted to the forgoing directors within
     one month from the date of the Meeting.

     Using The Black Scholes Model to valuate these options as follows:

              Volatility measured over 36 months: 63.90%
              Escrow period: 12 months
              Risk Free Rate: 5.36% (5 year Government Bonds)
              Exercise Price: $0.00

     The value of the options according to this model is AU$0.54 per option.

     The  Black  Scholes  Model  does  not take  into  consideration  the  other
     restrictions  and  hurdles  placed  on  these  options  as set  out  above.
     Therefore,  for accounting purposes,  we have applied a 35% discount to the
     above value, in-order to reflect these restrictions.

     We therefore  reach an  estimated  valuation of the options at AU$0.351 per
     option.

     The grant of options to Mr. Geoffrey Kempler is subject to Resolution 1 and
     11 being approved with or without amendment.

     The grant of options to Professor Colin Masters is subject to Resolution 11
     being approved with or without amendment.


--------------------------------------------------------------------------------
                                     Page 13




     The grant of options to Mr. Brian  Meltzer and Dr. George  Mihaly,  both of
     whom are Non - Executive Directors, is subject to Resolution 9 and 11 being
     approved with or without amendment.

     As a consequence of the interest of Mr. Geoffrey  Kempler,  Professor Colin
     Masters,  Mr. Brian Meltzer,  and Dr. George Mihaly in Resolutions  13, 14,
     15,  and 16,  respectively,  each such  person  absented  himself  from the
     discussion  of the Board of Directors  with respect to, and did not vote in
     respect  of, the  proposal  to present to the  Company's  shareholders  the
     respective  Resolution in which he has an interest or the accompanying part
     of this  Explanatory  Memorandum.  Dr. Jonas  Alsenas,  as Chief  Executive
     Officer  of the  Company,  and  drawing  upon  his  industry  knowledge  of
     like-sized  biotechnology  companies with NASDAQ listings,  recommends that
     shareholders  vote in favour of Resolutions 13, 14, 15, and 16, in order to
     enable the  Company to  continue to benefit  from Mr.  Geoffrey  Kempler's,
     Professor  Colin  Masters',  Mr. Brian  Meltzer's and Dr.  George  Mihaly's
     expertise.

17, 18
& 19   APPROVAL OF ISSUANCE OF ORDINARY SHARES IN LIEU OF BASE DIRECTORS FEES
       ----------------------------------------------------------------------

     At the 2003 annual  general  meeting of  shareholders  held on 17 December,
     2003,  shareholders  of the  Company  approved  the  issuance of fully paid
     ordinary  shares  to each of Mr.  Brian  Meltzer,  Dr.  George  Mihaly  and
     Professor  Colin  Masters,  directors  of the  Company,  in  lieu of a cash
     payment  of  AU$40,000  per each such  director  as an annual  base fee for
     director services.

     The Company  believes that such means of  remuneration is beneficial to the
     Company and it seeks shareholder  approval,  in accordance with ASX Listing
     Rule 10.14,  to issue to each of the  forgoing  directors,  in lieu of cash
     remuneration  to each director of an annual base fee for director  services
     in the amount of AU$40,000, fully paid ordinary shares of the Company. Such
     shares will be issued by the Company under and pursuant to the terms of the
     2004 Employees'  Directors' & Consultants'  Share & Option Plan, subject to
     its  adoption at the Meeting (or under any other share plan duly adopted by
     a majority of the  non-employee  members of the Board of  Directors  of the
     Company  or a  majority  of the  members  of a  committee  of  non-employee
     directors  established for such purpose).  If approved by the shareholders,
     such shares will be issued to the forgoing  directors within one month from
     the date of the Meeting.

     The number of ordinary  shares to be issued will be  calculated  based on a
     price per ordinary share equal to the lesser of:
     a)   80% of the average  market  price for the  Company's  ordinary  Shares
          calculated over the five days prior to the Meeting; or
     b)   80% of the average  closing  price for the Company's  ordinary  shares
          calculated over the six months prior to the Meeting.

     As a consequence  of the interest of Mr. Brian  Meltzer,  Dr. George Mihaly
     and Professor  Colin Masters in  Resolutions  17, 18 and 19,  respectively,
     each such  person  absented  himself  from the  discussion  of the Board of
     Directors  with respect to, and did not vote in respect of, the proposal to
     present to the Company's shareholders the respective Resolution in which he
     has an interest or the accompanying  part of this  Explanatory  Memorandum.
     Mr. Kempler and Dr. Alsenas recommend that shareholders of the Company vote
     in favour of  Resolutions  17, 18 and 19 in order to enable the  Company to
     continue to benefit  from Mr.  Brian  Meltzer's,  Dr.  George  Mihaly's and
     Professor Colin Masters' expertise.

--------------------------------------------------------------------------------
                                    Page 14









                                   ANNEXURE A
                                   ----------

                           PRANA BIOTECHNOLOGY LIMITED
                               ABN 37 080 699 065
                2004 AMERICAN DEPOSITARY SHARE (ADS) OPTION PLAN

Prana  Biotechnology  Limited,  a  corporation  formed  under  the  laws  of the
Commonwealth  of Australia (the  "Company"),  hereby  establishes and adopts the
following  2004  American  Depository  Share  (ADS)  Option  Plan (the  "Plan"),
effective November 17, 2004 (the "Effective  Date"),  subject to the approval of
the Plan by the  majority of the shares  entitled to vote at a duly  constituted
meeting of the shareholders of the Company.

1. Purpose.
   -------

The  purpose  of the  Plan is to  promote  the  interests  of the  Company,  its
Subsidiaries  and  shareholders by enabling the Company and its  Subsidiaries to
attract and retain outstanding  employees,  officers,  consultants,  independent
contractors  and  directors  ("Eligible  Persons")  and align the  interests  of
Eligible  Persons  with those of the  Company and its  shareholders  through the
incentive   inherent  in  the  ownership  of  ordinary  shares  of  the  Company
("Shares").  For  purposes  of  the  Plan,  the  term  "Subsidiary"  shall  mean
"subsidiary  corporation,"  as such term is  defined  in  Section  424(f) of the
Internal  Revenue  Code of 1986,  as amended (the  "Code").  For purposes of the
Plan,  the term  "Award"  shall mean a grant of an option to  purchase  American
Depositary Shares ("ADSs") representing Shares.

2. Shares Subject to Awards.
   ------------------------

(a) Awards under the Plan ("Awards") may be granted in the following forms:

         (i) incentive stock options  ("Incentive Stock Options") as provided in
         Section 422 of the Code; provided,  however, that no Award of Incentive
         Stock Options shall be made hereunder  after the date that is the tenth
         anniversary of the Effective Date; and

         (ii) non-qualified  stock options  ("Non-qualified  Options") (the term
         "Options" includes incentive stock options and non-qualified options).

 (b) Subject to the  adjustment  provisions of Section 11 hereof,  the aggregate
number of ADSs which may be issued under options under the Plan shall not exceed
1,200,000  (the  equivalent of 12,000,000  Shares),  and the number of ADSs with
respect to which  Options may be granted to any  employee in any  calendar  year
shall not exceed 500,000 (the  equivalent of 5,000,000  Shares).  ADSs delivered
under the Plan may be authorized and unissued ADSs or issued ADSs  reacquired by
the Company,  or both.  The ADSs that are forfeited  under the terms of the Plan
and ADSs that are the subject of Options  that expire  unexercised  or which are
otherwise  surrendered  by the holder of such  Option (the  "Optionee")  without
receiving  any payment or other  benefit with  respect  thereto may again become
available for new Awards under the Plan.

3. Administration of the Plan.
   --------------------------

The Plan shall be  administered  by a committee (the  "Committee")  comprised of
members of the Board of Directors of the Company (the  "Board")  selected by the
Board.  The Board may remove  from,  add  members to, or fill  vacancies  in the
Committee.  The Committee shall consist of a compensation committee of the Board
comprised  solely of two or more  "outside  directors"  within  the  meaning  of
Section  162(m)(4)(C)(i)  of the Code, unless the Board determines that there is
no need to comply with the requirements of Section 162(m) of the Code.

The Committee is authorized, subject to the provisions of the Plan, to establish
such  rules  and  regulations  as it may deem  appropriate  for the  conduct  of
meetings and proper  administration  of the Plan.  All actions of the  Committee
shall be taken by majority vote of its members,  except that the members thereof
may  authorize  any one or more of their number or any officer of the Company to
execute  and  deliver  documents  on behalf  of the  Committee.  Subject  to the
provisions  of the  Plan,  the  Committee  shall  have  authority,  in its  sole
discretion,  to grant Awards under the Plan, to interpret the  provisions of the
Plan and to prescribe,  amend, and rescind rules and regulations relating to the
Plan  or any  Award  thereunder  as it may  deem  necessary  or  advisable.  All
decisions made by the Committee  pursuant to the provisions of the Plan shall be
final,  conclusive and binding on all persons.  No member of the Committee shall
be liable for anything  done or omitted to be done by him or by any other member
of the  Committee  in  connection  with the  Plan,  except  for his own  willful
misconduct or as expressly provided by statute.





4. Eligibility.
   -----------

Awards  shall be made to such  Eligible  Persons  of the  Company  or any of its
Subsidiaries as the Committee shall select from time to time; provided, however,
that Incentive Stock Options may only be granted to employees of the Company and
its Subsidiaries (including, without limitation,  officers and directors who are
also employees of the Company and its  Subsidiaries) and shall not be granted to
any owner of 10% or more of the total  combined  voting  power of all classes of
stock of the Company and its Subsidiaries, as determined under Section 422(b)(6)
of the Code.  The  Committee's  designation of an Optionee in any year shall not
require the  Committee to designate  such person to receive  Awards or grants in
any other year.

5. Stock Option  Agreements.  All Options granted  pursuant to the Plan shall be
evidenced in writing by option agreements ("Option Agreements") in such form and
containing  such terms and conditions as the Committee shall determine which are
not inconsistent with the provisions of the Plan, including the following:

(a) Type of Option; Number of ADSs. Each Option shall be designated as either an
Incentive Stock Option or a Non-qualified  Option.  Each Option  Agreement shall
state the total  number of ADSs to which it  pertains.  To the  extent  that the
aggregate Fair Market Value, as defined below and determined on the date that an
Option is granted,  of ADSs with  respect to which  Incentive  Stock  Option are
exercisable  for the first time by an Optionee  during any calendar  year (under
all plans of the Company and its Subsidiaries) exceeds U.S.$100,000, such Option
shall be treated as a Non-qualified Option.

(b) Option Price.  The Option exercise price per each ADS shall be determined by
the  Committee  at the time any  Option is  granted  and  stated  in the  Option
Agreement;  provided,  that the  exercise  price per ADS of an  Incentive  Stock
Option and an Option that needs to satisfy the requirements of Section 162(m) of
the Code shall not be less than 100% of the Fair Market Value of such ADS on the
date of the Award.  Notwithstanding the preceding sentence, the price per ADS of
an Incentive Stock Option awarded to an Optionee who, at the time such Option is
granted,  owns stock  representing  more than 10% of the total  combined  voting
power of all classes of stock of the Company or its  Subsidiaries,  shall not be
less than 110% of the Fair Market Value of such ADS on the date of the Award.

For all  purposes  under the Plan,  Fair  Market  Value  shall  mean the per ADS
closing price of the ADSs for the day immediately preceding the date as of which
Fair Market Value is being determined (or if there was no reported closing price
on such  date,  on the  last  preceding  date on which  the  closing  price  was
reported)  reported on the National  Association of Securities Dealers Automated
Quotations  (NASDAQ) system, or other national  securities exchange on which the
ADSs are then principally traded, and reported in the trading tables of The Wall
Street Journal.

(c) Option Term.  The period for which the Option is granted shall be determined
by the Committee and set forth in the Option Agreement;  provided, however, that
no Option shall be  exercisable  after the expiration of ten years from the date
of  its  Award.  Notwithstanding  the  preceding  sentence,  in the  case  of an
Incentive  Stock Option  granted to an Optionee  who, at the time such Option is
granted,  owns stock  representing more than 10% of the combined voting power of
all classes of stock of the Company or its Subsidiaries,  the term of the Option
shall be five  years from the date of the Award or such  shorter  term as may be
provided  in the  Option  Agreement.  No  Option  may  be  exercised  after  the
expiration of its term.

(d) Vesting Period. Except as otherwise provided in the Plan or by the Committee
in  an  Option  Agreement,  Options  shall  become  vested  and  exercisable  in
accordance with the following vesting schedule:

     less than one year after date of Award.             0% of the total Award
     one year after date of Award. . . . . . . .        25% of the total Award
     two years after date of Award. . . . . . . .       50% of the total Award
     three years after date of Award. . . . . . .       75% of the total Award
     four years after date of Award. . . . . . . .      100% of the total Award

Options shall  automatically cease to vest in accordance with the above schedule
and,  except as provided in Sections 7, 8, 9 and 10,  shall become null and void
upon the termination of employment for any reason.

(e) Time and Manner of Payment. Each Option Agreement shall provide that Options
granted under the Plan shall be exercised by the Optionee (or by his  executors,
administrators,  guardian or legal  representative)  as to all or any portion of
the ADSs  covered  thereby,  by the giving of written  notice of exercise to the
Company,  specifying  the number of ADSs to be  purchased.  Full payment of such
purchase  price shall be made within ten business days  following the receipt of
such notice by the Company and shall be made (i) in cash, by certified  check or
bank check,  or (ii) in any other  manner  permitted  in the  discretion  of the
Committee.  Such notice of exercise and full payment,  shall be delivered to the
Company at its principal  business  office or such other office as the Committee
may  direct,  and shall be in such  form,  containing  such  further  provisions
consistent  with the provisions of the Plan, as the Committee may prescribe.  In
no event may any Option granted hereunder be exercised for a fraction of an ADS.
The Company  shall issue or cause to be issued to the Optionee  ADSs or American
Depositary Receipts ("ADRs") evidencing the ADSs as soon as practicable after an
Option is exercised,  and,  within a reasonable time  thereafter,  such issuance
shall be evidenced on the books of the Company.  No person  exercising an Option
shall have any of the rights of





a holder  of ADSs  prior to the date that such  ADSs are  issued  following  the
exercise of such Option. No adjustment shall be made for cash dividends or other
rights for which the record date is prior to the date of such issuance.

(f) Other  Provisions.  An Option  Agreement  may  contain  any other  terms and
conditions  that the  Committee,  in its  sole  discretion,  deems  appropriate;
provided, however, that no such term or condition shall be inconsistent with the
terms of the Plan or, in the case of an Incentive  Stock Option,  Section 422 of
the Code.  Each Option  Agreement  may condition the exercise of any Option upon
the attainment of specified productivity goals by a Company group or division or
an individual Optionee.

6. Non-Transferability of Options.
   ------------------------------

No Option shall be assignable  or  transferable  by the Optionee,  other than by
will or the laws of descent and  distribution,  and may be exercised  during the
lifetime  of  the  Optionee  only  by the  Optionee  or his  guardian  or  legal
representative.

7. Termination of Employment.
   -------------------------

(a) Except as  otherwise  determined  by the  Committee or provided in an Option
Agreement,  in the event of the  termination  of  employment  or  service  of an
Optionee  with the  Company  and its  Subsidiaries  for any reason  (other  than
termination for cause, death,  disability or Change of Control of the Company as
provided below), Options granted to him that have not previously expired or been
exercised  shall,  to the  extent  vested  on the date of such  termination,  be
exercisable by the Optionee  within 30 days after the date of such  termination,
unless such Option is earlier terminated pursuant to its terms. All Options that
are not  exercisable  as of the  date  of  such  termination  or  which  are not
exercised within 30 days thereafter, shall be deemed cancelled and terminated as
of such date.

(b) Except as  otherwise  determined  by the  Committee or provided in an Option
Agreement,  in the event an Optionee retires from employment or service with the
Company and its Subsidiaries, Options granted to him shall become 100% vested as
of the  effective  date of the  Optionee's  retirement.  Whether an Optionee has
terminated  employment  on  account of  retirement  shall be  determined  by the
Committee in its sole discretion.

(c) Except as  otherwise  determined  by the  Committee or provided in an Option
Agreement,  in the event that an Optionee's  employment or service is terminated
by the Company or any of its Subsidiaries  for "cause," all Options,  whether or
not  exercisable  as of the  date of such  termination,  shall be  canceled  and
terminated as of such date. For these  purposes,  termination  for "cause" shall
mean the following:  the  Optionee's  violation of copyright,  trademark  and/or
patent  protection  maintained  by the Company or a Subsidiary;  the  Optionee's
engaging  or  assisting  in any  business in  competition  with the Company or a
Subsidiary  as  employee,  owner,  partner,  director,   officer,   stockholder,
consultant  or  agent  (ownership  of  minority   interests  in  publicly-traded
corporations,  partnerships  or  companies  or of 5% or  less of the  equity  of
privately-held  corporations,  partnerships or companies shall not be considered
competition for purposes of this Plan); the Optionee's dishonesty,  or acting in
any  manner  inconsistent  with  the  utmost  good  faith  and  loyalty  in  the
performance of the Optionee's  duties;  conviction of the Optionee by a court of
law of competent jurisdiction for fraud, misappropriation,  embezzlement, or any
felony;  failure  of the  Optionee  to  perform  his  duties  to the  reasonable
satisfaction of the Company or its Subsidiaries.

8. Death.
   -----

Except  as  otherwise  determined  by the  Committee  or  provided  in an Option
Agreement,  in the event an Optionee dies while employed by or providing service
to the Company or any of its  Subsidiaries,  all unvested  Options  shall become
100%  vested and any Option  granted to him that has not  previously  expired or
been  exercised  shall be  exercisable  by the estate of such Optionee or by any
person who acquired  such Option by bequest or  inheritance,  at any time within
one year after the date of death of the Optionee,  unless such Option is earlier
terminated pursuant to its terms. All Options not exercised within such one year
period shall be deemed  canceled and terminated on the first  anniversary of the
Optionee's death.






9. Disability.
   ----------

Except  as  otherwise  determined  by the  Committee  or  provided  in an Option
Agreement,  in the event of the  termination of employment of an Optionee due to
total disability,  the Optionee or his guardian or legal  representative,  shall
have the right to exercise any Option which has not been previously exercised or
expired and which the  Optionee was eligible to exercise as of the first date of
total  disability,  at any time within one year after such  termination,  unless
such Option is earlier  terminated  pursuant to its terms.  All Options that are
not  exercisable as of the date of the  Optionee's  termination or which are not
exercised  within one year thereafter shall be deemed canceled and terminated as
of such applicable date. The term "total disability" shall, for purposes of this
Plan, be defined in the same manner as such term is defined in Section  22(e)(3)
of the Code and shall be determined by the Committee in its sole discretion.

10. Change of Control.
    -----------------

(a) In the event of a proposed sale or conveyance of all or substantially all of
the assets of the Company,  or the merger or consolidation of the Company and/or
its Subsidiaries with or into another corporation, each outstanding Option shall
be  assumed  or an  equivalent  option  shall be  substituted  by the  successor
corporation or a parent or subsidiary of the successor corporation. In the event
that such successor  corporation  refuses to assume such Option or to substitute
an  equivalent  option,  such Option may, at the  discretion  of the  Committee,
become 100% vested upon the consummation of the merger or sale of assets.

(b) Except as  otherwise  determined  by the  Committee or provided in an Option
Agreement,  in the event of the involuntary termination of employment or service
of an Optionee  from the Company and its  Subsidiaries  on account of and within
six  months  of a  Change  of  Control  of the  Company,  as  determined  by the
Committee,  Options granted to such Optionee that have not previously expired or
been  exercised  shall become 100% vested as of the date of such  termination of
employment and shall be  exercisable  by the Optionee  within 30 days after such
date, unless such Option is earlier  terminated  pursuant to its terms. A Change
of Control shall be deemed to have occurred when:

           (i) any person  (as such term is used in  Section 13 of the  Exchange
           Act and the rules and regulations thereunder),  and any person acting
           in concert  with such  person,  directly or  indirectly,  acquires or
           otherwise  becomes entitled to vote more than 50% of the voting power
           entitled to be cast at elections for directors of the Company; or

           (ii) there occurs any merger or consolidation of the Company,  or any
           sale,  lease  or  exchange  of  all or any  substantial  part  of the
           consolidated  assets of the Company and its Subsidiaries to any other
           person, and (A) in the case of a merger or consolidation, the holders
           of outstanding  stock of the Company entitled to vote in elections of
           directors   of  the  Company   immediately   before  such  merger  or
           consolidation (excluding for this purpose any person that directly or
           indirectly  owns or is  entitled  to vote  20% or more of the  voting
           power of the  Company)  hold less than 50% of the voting power of the
           survivor of such merger or consolidation or its parent, or (B) in the
           case of any such sale, lease or exchange, the Company does not own at
           least 50% of the voting power of the other person; or

           (iii) one or more new  directors  of the  Company  are elected and at
           such time five or more  directors  (or,  if less,  a majority  of the
           directors)  then holding office were not nominated as candidates by a
           majority of the directors in office immediately before such election.

11. Adjustments.
    -----------

Except in the case of a Change of Control of the  Company as provided in Section
10, in the event that the Committee  shall  determine that any dividend or other
distribution  (whether in the form of cash,  ADSs,  other  securities,  or other
property),  recapitalization,  stock split, reverse stock split, reorganization,
merger, consolidation,  split-up, spin-off, combination, repurchase, or exchange
of ADSs or other  securities,  the  issuance  of  warrants  or other  rights  to
purchase ADSs or other  securities,  or other similar  corporate  transaction or
event  affects the ADSs with respect to which Options have been or may be issued
under the Plan,  such that an  adjustment  is  determined by the Committee to be
appropriate  in order to prevent  dilution  or  enlargement  of the  benefits or
potential  benefits  intended  to be made  available  under the  Plan,  then the
Committee shall, in such manner as the Committee may deem equitable,  adjust any
or all of (i) the  number  and type of shares  that  thereafter  may be made the
subject of Options,  (ii) the number and type of shares  subject to  outstanding
Options,  and (iii) the exercise price with respect to any Option, or, if deemed
appropriate,  make provision for a cash payment to the holder of any outstanding
Option;  provided,  however,  that the  number  of ADSs  subject  to any  Option
denominated in ADSs shall always be a whole number.

12. Tax Withholding.
    ---------------

The Company shall notify an Optionee of any income tax withholding  requirements
arising  as a result of the grant of any Award or  exercise  of an  Option.  The
Company  shall have the right to withhold  from the  Optionee  such  withholding
taxes as may be  required by law, or to  otherwise  require the  Optionee to pay
such withholding taxes. If the Optionee shall fail to make such tax



payments as are required,  the Company or its Subsidiaries  shall, to the extent
permitted  by law,  have the  right to  retain  and  withhold  a number of ADSs,
otherwise due to such  Optionee,  having a market value not less than the amount
of such taxes  required to be withheld by the Company to  reimburse  the Company
for any such taxes and cancel (in whole or in part) any such ADSs so withheld.

13. Right of Discharge Reserved.
    ---------------------------

Nothing in the Plan nor the grant of an Award  hereunder  shall  confer upon any
employee,  officer,  director,  consultant,   independent  contractor  or  other
individual  the right to  continue  in the  employment  of or  service  with the
Company or any of its  Subsidiaries  or affect any right that the Company or any
Subsidiary  may have to terminate the  employment or service of (or to demote or
to exclude  from  future  Options  under the Plan) any such  employee,  officer,
director, consultant, independent contractor or other individual at any time for
any reason. Except as specifically provided by the Committee,  the Company shall
not be liable for the loss of existing or potential profit from an Award granted
in the event of  termination  of an employment or service or other  relationship
even if the  termination  is in violation of an obligation of the Company or any
Subsidiary  of the Company to the  employee,  officer,  director,  consultant or
independent contractor.

14. Severability.
    ------------

If any  provision  of the Plan shall be held  unlawful or  otherwise  invalid or
unenforceable   in  whole  or  in  part,   such   unlawfulness,   invalidity  or
unenforceability  shall  not  affect  any  other  provision  of the Plan or part
thereof,  each of which  remain in full force and  effect.  If the making of any
payment or the provision of any other benefit  required  under the Plan shall be
held  unlawful  or  otherwise  invalid  or  unenforceable,   such  unlawfulness,
invalidity  or  unenforceability  shall not prevent any other payment or benefit
from being made or provided  under the Plan,  to the extent that it would not be
unlawful,  invalid or  unenforceable,  and the maximum  payment or benefit  that
would not be unlawful,  invalid or unenforceable shall be made or provided under
the Plan.

15. Amendment and Termination of the Plan.
    -------------------------------------

The Board may, from time to time,  alter,  amend,  suspend or terminate the Plan
with respect to Options that have not been granted,  subject to any  requirement
for  stockholder  approval  imposed by  applicable  law or any rule of any stock
exchange  or  quotation  system on which ADSs are  listed or  quoted;  provided,
however,  that the Board may not amend the Plan in any manner that would  result
in  non-compliance  with any applicable law. Neither the Board nor the Committee
may, without the consent of the Optionee,  alter or in any way impair the rights
of such Optionee under any Award previously granted.  Neither the termination of
the Plan nor the  Change of  Control  of the  Company  shall  affect  any Option
previously granted.

If the approval of the Plan by the stockholders is not obtained within 12 months
of the  Effective  Date,  the Plan  shall be null and void and each  Award of an
Option hereunder shall be null and void.

16. Conditions Upon Issuance of ADSs.
    --------------------------------

ADSs  shall not be issued  pursuant  to the  exercise  of an Option  unless  the
exercise of such Option and the  issuance  and delivery of such ADSs or the ADRs
evidencing  such ADSs shall  comply  with  applicable  laws and shall be further
subject  to the  approval  of  counsel  for the  Company  with  respect  to such
compliance.  As a condition to exercise of an Option,  the Committee may require
the  person  exercising  the  Option to  represent  and  warrant  at the time of
exercise that the ADSs are being  purchased  only for investment and without any
present intention to sell or distributed such ADSs.

17. Gender and Number.
    -----------------

Any  masculine  terminology  used in this Plan  document  shall also include the
feminine,  and the  definition  of any term  herein in the  singular  shall also
include the plural except when otherwise indicated by the context.

18. Governing Law.
    -------------

The Plan and all determinations made and actions taken thereunder, to the extent
not otherwise  governed by the Code or the laws of the United  States,  shall be
governed by the laws of the State of New York and construed accordingly.
































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                                   ANNEXURE B
                                   ----------

                           PRANA BIOTECHNOLOGY LIMITED
                               ABN 37 080 699 065
       2004 EMPLOYEES', DIRECTORS' AND CONSULTANTS' SHARE AND OPTION PLAN

1.       PURPOSE

         The  Board  of  Directors  of the  Company  proposes  to  introduce  an
         employee,  director and consultants share and option plan, to be called
         the  Prana  Biotechnology  Limited  2004  Employees',   Directors'  and
         Consultants'  Share and Option  Plan  ("2004 ASX Plan") for the purpose
         of: 
          (a)  providing  Eligible Persons with an additional  incentive to work
               to improve the performance of the Company;
          (b)  attracting  and  retaining  Eligible  Persons  essential  for the
               continued growth and development of the Company;
          (c)  to promote  and  foster  loyalty  and  support  amongst  Eligible
               Persons for the benefit of the Company; and
          (d)  to enhance the  relationship  between  the  Company and  Eligible
               Persons for the long term mutual benefit of all parties.

2.       COMMENCEMENT

         Subject to the adoption of the 2004 ASX Plan by the shareholders of the
         Company at the 2004  Annual  General  Meeting of the Company and to due
         compliance with the Corporations Act 2001, the 2004 ASX Plan shall take
         effect  as of the  date  of the  2004  Annual  General  Meeting  of the
         Company.

3.       DEFINITIONS

         In these Rules, unless the context otherwise requires:
          "Subsidiary" means such term as defined in the Australian Corporations
          Act 2001;
          "ASX" means Australian Stock Exchange Limited;
          "Company" means Prana Biotechnology Limited ACN 080 699 065;
          "Board of Directors"  means the Board of Directors of the Company from
          time  to  time  acting  by  resolution  made in  accordance  with  the
          Corporations Act 2001 and the Constitution of the Company;
          "Director" means a director from time to time of the Company;
          "Eligible Person" means a person who is:
               (i) an employee of; or
               (ii) a director of; or
               (iii) a consultant to, 
          the Company or any Subsidiary;
          "Listing  Rules" means the Listing Rules from time to time of the ASX;
          "Option" means an option to purchase Shares;
          "Rules"  means the rules of the 2004 ASX Plan, as amended from time to
          time;
          "Share"  means an ordinary  fully paid share ranking pari passu in the
          capital  of the  Company;  and  
          "Unexercised  Options"  means Options  granted under the 2004 ASX Plan
          from  time to time  which  have  not  been  exercised  or  expired  in
          accordance with their terms and the terms of the 2004 ASX Plan.

4. MAXIMUM AGGREGATE NUMBER OF SHARES ISSUABLE UNDER THE 2004 ASX PLAN

         The aggregate number of Shares issuable under the 2004 ASX Plan, either
         by the issuance of Shares or under  Options  granted under the 2004 ASX
         Plan, shall not exceed 12,000,000 ordinary shares.

5.       ADMINISTRATION OF THE 2004 ASX PLAN

         The  2004  ASX  Plan  shall  be   administered   by  a  committee  (the
         "Committee")  comprised  of  members of the Board of  Directors  of the
         Company,  selected by the Board of  Directors.  The majority of members
         shall be independent non-executive directors.

         The Committee is authorised,  subject to the provisions of the 2004 ASX
         Plan,  to  establish  such  rules  and   regulations  as  it  may  deem
         appropriate  for the conduct of meetings and proper  administration  of
         the 2004 ASX  Plan.  All  actions  of the  Committee  shall be taken by
         majority  vote of its  members,  except  that the  members  thereof may
         authorise  any one or more of them or any  officer  of the  Company  to
         execute and deliver  documents on behalf of the  Committee.  Subject to
         the  provisions  of  the  2004  ASX  Plan,  the  Committee  shall  have
         authority,  in its sole discretion,  to issue securities under the 2004
         ASX  Plan,  to  interpret  the  provisions  of the 2004 ASX Plan and to
         prescribe,  amend,  and rescind rules and  regulations  relating to the
         2004 ASX Plan or any  issue  thereunder  as it may  deem  necessary  or
         advisable.  All  decisions  made  by  the  Committee  pursuant  to  the
         provisions of the 2004 ASX Plan shall be final,  conclusive and binding
         on all persons. No member of the Committee shall be liable for anything
         done  or  omitted  to be  done  by him or by any  other  member  of the
         Committee  in  connection  with the 2004 ASX Plan,  except  for his own
         willful misconduct or as expressly provided by law.

6.       APPLICATION

         All  Options or Shares  offered to an eligible  person  pursuant to the
         2004 ASX Plan shall be  evidenced in writing by a Share or Option offer
         document  ("Offer  Document").  The Offer  Document  shall contain such
         terms and conditions as





         the Committee  shall  determine,  which are not  inconsistent  with the
         provisions of the 2004 ASX Plan, including the following:

          a)   QUANTITY
               --------

               The  quantity  of Shares to be issued or  Options  to be  granted
               under the Offer Document.

          b)   EXERCISE PRICE OF OPTIONS
               -------------------------

               The  exercise  price of an Option  issued under the 2004 ASX Plan
               will be equal to less than market  value of an ordinary  share on
               the ASX at the date of grant or such  other  exercise  price that
               the   Committee   determines   to  be   appropriate   under   the
               circumstances.

               Market  value  will be  determined  by  reference  to the  volume
               weighted  average  market price of the Company's  ordinary  share
               during the five trading days on the ASX up to and  including  the
               date of grant of the  options or such other date or period as the
               Committee shall consider appropriate.

          c)   OPTION TERMS
               ------------

               The term of an Option shall be  determined  by the  Committee and
               set  forth in the  Offer  Document;  provided,  however,  that no
               Option shall be  exercisable  after the  expiration  of ten years
               from the date of its grant.

          d)   ESCROW TERM; VESTING PERIOD
               ---------------------------

               Except as otherwise  provided in the 2004 ASX Plan or  determined
               by the Committee and set forth in an Offer Document, the issuance
               of Shares and  exercise of Options  shall be subject to either an
               escrow or vesting schedule,  as the Committee shall determine and
               set forth in the Offer Document, in accordance with the following
               terms and conditions:

               (i)  Escrow Term. In the event that the Committee shall determine
                    that the issuance of Shares and exercise of Options shall be
                    subject to an escrow, Shares issued or Options granted under
                    the  2004 ASX  Plan  cannot  be  disposed  of or  exercised,
                    respectively,  within six  months  from the date of issue or
                    grant (or 12 months if  issued or  granted  to a  Director).
                    Shares issued or Options granted under the 2004 ASX Plan may
                    be  disposed  of or  exercised  at any time from six  months
                    after the date of  issuance  or grant,  respectively  (or 12
                    months if issued or granted to a  Director),  subject to any
                    other terms of the issuance or grant.

               (ii) Vesting  Period.  In the  event  that  the  Committee  shall
                    determine  that the  issuance  of  Shares  and  exercise  of
                    Options shall be subject to a vesting schedule, the issuance
                    of Shares and exercise of Options  shall  become  vested and
                    issued  or  exercisable  in  accordance  with the  following
                    vesting schedule:



                                                                        
               less than one year after date of issuance or grant . .      0% of the total number granted
               one year after date of issuance or grant. . . . . . . .     25% of the total number granted 
               two years after date of issuance or grant. . . . . . .      50% of the total number granted
               three years after date of issuance or grant   . . . . .     75% of the total number granted
               four years after date of issuance or grant  . . . . . .     100% of the total number granted


               Shares  and  options  shall   automatically   cease  to  vest  in
               accordance  with the above  schedule  and,  except as provided in
               Sections  9, 11, 12 and 13,  shall  become null and void upon the
               termination of employment for any reason.

          e)   TIME AND MANNER OF PAYMENT OF EXERCISE OF OPTIONS
               -------------------------------------------------
             
               Each Offer Document shall provide that Options  granted under the
               2004 ASX Plan  shall be  exercised  by the  Eligible  Person  (or
               nominee) as to all or any portion of the Shares covered  thereby,
               by the  giving of  written  notice of  exercise  to the  Company,
               specifying the number of Options to be exercised. Full payment of
               such  exercise  price  shall be made  within  ten  business  days
               following  the receipt of such notice by the Company and shall be
               made  (i) in cash or bank  cheque,  or (ii) in any  other  manner
               permitted  in the  discretion  of the  Committee.  Such notice of
               exercise and full  payment,  shall be delivered to the Company at
               its  principal  business  office  or  such  other  office  as the
               Committee may direct, and shall be in such form,  containing such
               further provisions consistent with the provisions of the 2004 ASX
               Plan, as the Committee may prescribe.  The Company shall issue or
               cause to be issued to the Eligible  Person ordinary shares of the
               Company as soon as practicable after an Option is exercised, and,
               within a  reasonable  time  thereafter,  such  issuance  shall be
               evidenced on the books of the Company.  No person  exercising  an
               Option  shall have any of the  rights of a holder of an  ordinary
               share  prior to the date that such  ordinary  shares  are  issued
               following  the exercise of such Option.  No  adjustment  shall be
               made for cash dividends or other rights for which the record date
               is prior to the date of such issuance.






7.       CANCELLATION OF OFFER

         The Board of Directors  retains the right to withdraw an Offer Document
         at any time prior to receiving an acceptance  from the Eligible  Person
         to whom the offer was made, or that Eligible Person's nominee.

8.       ACCEPTANCE

         (a)  The Company shall be obliged to accept any acceptance  application
              made pursuant to Rule 6, provided that the application accords, in
              all respects, with these Rules and is for such number of Shares or
              Options,  or  part  thereof,  to  which  the  Eligible  Person  is
              entitled.  Upon  acceptance of a duly complying  application,  the
              Company,   within  ten  business  days,  shall  deliver  a  Option
              Certificate  or  confirmation  of Share  issue in  respect  of the
              Shares or Options granted to the Eligible Person.
         (b)  Each Eligible Person (and, if applicable, his or her nominee) will
              be taken to agree to be bound by these  Rules upon the  acceptance
              of the offer from the Committee to take up Shares or Options under
              this 2004 ASX Plan.

9.       OTHER CONDITIONS

         (a)  The Offer Document may contain any other terms and conditions that
              the Committee, in its sole discretion, deems appropriate; provided
              however  that such terms or  condition  shall not be  inconsistent
              with the terms of the 2004 ASX Plan,  Corporations Act 2001 or ASX
              Listing Rules.
         (b)  Subject to the terms and  conditions set forth in the rules of the
              2004  ASX  Plan,  Shares  and  Options  may  be  assigned  at  the
              discretion of the Committee. The instrument of assignment shall be
              duly executed and shall be lodged at the registered  office of the
              Company  together with such other  information  as the Company may
              reasonably require with respect to the assignment, and the Company
              shall  enter the name of the  assignee  in a register of Shares or
              Options  as the  holder of the  relevant  Shares or  Options.  The
              Company  shall not be bound to recognise  the  assignment  until a
              copy of the duly executed  instrument of assignment is lodged with
              the Company.
         (c)  Options shall not be listed for official quotation on the ASX.
         (d)  Shares issued under the 2004 ASX Plan shall be listed for official
              quotation on the ASX. The Company  shall,  in accordance  with the
              Listing Rules, apply to have Shares issued pursuant to an exercise
              of Options listed for official quotation by the ASX.
         (e)  Options cannot be granted to Directors or their associates  unless
              prior  approval  of the  Company's  shareholders  is  obtained  in
              accordance with the Listing Rules.
         (f)  The Options  will not give any right to  participate  in dividends
              until  Shares are issued  pursuant to the exercise of the relevant
              Options.
         (g)  In the event of the proposed  dissolution  or  liquidation  of the
              Company, all outstanding Options will terminate  immediately prior
              to the  consummation  of such proposed  action,  unless  otherwise
              provided by the Board of Directors. The Board of Directors may, in
              the exercise of its sole  discretion  in such  instances,  declare
              that any Option  shall  terminate  as of a date fixed by the Board
              and give each  Eligible  Person the right to  exercise  his or her
              Options as to all or any part of the  Optioned  Shares,  including
              Shares as to which the Option would not otherwise be exercisable.
         (h)  In  the  event  of  a  proposed  sale  or  conveyance  of  all  or
              substantially  all of the assets of the Company,  or the merger or
              consolidation  of the Company  with or into  another  corporation,
              each outstanding  Option shall be assumed or an equivalent  option
              shall be substituted  by the successor  corporation or a parent or
              subsidiary  of the successor  corporation.  In the event that such
              successor   corporation  refuses  to  assume  such  Option  or  to
              substitute  an  equivalent   option,   such  Option  may,  at  the
              discretion  of  the   Committee,   accelerate  in  full  upon  the
              consummation of the merger or sale of assets.
         (i)  The Committee shall have the power and right,  but not obligation,
              to accelerate the  exercisability of any Options,  notwithstanding
              any  limitations  in this 2004 ASX Plan,  upon a Change in Control
              (as defined herein below).  In the event of a Change in Control of
              the  Company,  whether  by  tender  offer for more than 50% of the
              outstanding  voting  shares,  proxy  contest  for the  election of
              members of the Board of Directors or other means,  which lacks the
              approval  of the  Board (a  "Hostile  Change  in  Control"),  each
              outstanding  Option  under this 2004 ASX Plan shall  automatically
              accelerate  in  full  and  unvested  Shares  shall  vest  in  full
              immediately.  For  purposes  of the 2004 ASX Plan,  a  "Change  in
              Control"  shall be deemed to have  occurred if any person,  or any
              two or more persons acting as a group,  and all affiliates of such
              person or  persons,  who prior to such time  owned less than fifty
              percent  (50%)  of the then  outstanding  ordinary  shares  of the
              Company,  shall  acquire such  additional  shares of the Company's
              ordinary  shares  in  one  or  more  transactions,  or  series  of
              transactions,    such   that   following   such   transaction   or
              transactions, such person or group and affiliates beneficially own
              more  than  fifty  percent  (50%)  of  the  Company's  outstanding
              ordinary shares.
         (j)  In the  event  that all or  substantially  all of the  issued  and
              outstanding  capital of the  Company  is to be sold (the  "Sale"),
              each  Eligible  Person shall be obligated to  participate  in such
              Sale and sell his or her Shares  and/or  Options  in the  Company,
              provided, however, that each such Share or Option shall be sold at
              a price  equal to that of any  other  Share  sold  under  the Sale
              (minus the applicable exercise price), and subject to the absolute
              discretion of the Board of Directors.






10.      RIGHTS OF EMPLOYEES

         The 2004 ASX Plan  shall not form part of any  contract  of  employment
         between  the  Company  and any of its  employees  and shall not confer,
         directly or indirectly,  on any employee any legal or equitable  rights
         whatsoever against the Company.  Without limiting the generality of the
         following, nothing in these Rules:
          (a) confers on any Eligible Person the right to receive any Shares and
          Options;
          (b) confers on any person the right to continue as an employee;
          (c) affects any rights  which the  Company may have to  terminate  the
          employment of any employee; or
          (d) may be used to increase  damages in any action brought against the
          Company in respect of such termination.

11.      TERMINATION OF EMPLOYMENT

         (a) Except as otherwise  determined  by the Committee or provided in an
         Offer  Document,  in the  event of the  termination  of  employment  or
         service of an Eligible Person with the Company and its Subsidiaries for
         any reason  (other than  termination  for cause,  death,  disability or
         Change of Control of the Company as provided in these  Rules),  Options
         granted  to him that  have not  previously  expired  or been  exercised
         shall,  to the  extent  vested  on the  date  of such  termination,  be
         exercisable  by the  Eligible  Person  within 30 days after the date of
         such termination,  unless such Option is earlier terminated pursuant to
         its terms.  All Options that are not exercisable as of the date of such
         termination or which are not exercised within 30 days thereafter, shall
         be deemed cancelled and terminated as of such date.

         (b) Except as otherwise  determined  by the Committee or provided in an
         Offer Document, in the event an Eligible Person retires from employment
         or service with the Company and its  Subsidiaries,  Options  granted to
         them shall become 100% vested as of the effective  date of the Eligible
         Persons   retirement.   Whether  an  Eligible   Person  has  terminated
         employment  on  account  of  retirement  shall  be  determined  by  the
         Committee in its sole discretion.

         (c) Except as otherwise  determined  by the Committee or provided in an
         Offer  Document,  in the event that an Eligible  Persons  employment or
         service is  terminated  by the Company or any of its  Subsidiaries  for
         "cause," all Options, whether or not exercisable as of the date of such
         termination,  shall be cancelled and  terminated  as of such date.  For
         these purposes,  termination for "cause" shall mean the following:  the
         Eligible  Person's  violation of  copyright,  trademark  and/or  patent
         protection  maintained  by the Company or a  Subsidiary;  the  Eligible
         Person  engaging or assisting in any business in  competition  with the
         Company or a Subsidiary as employee, owner, partner, director, officer,
         stockholder,  consultant or agent  (ownership of minority  interests in
         publicly-traded  corporations,  partnerships  or  companies or of 5% or
         less of the  equity of  privately-held  corporations,  partnerships  or
         companies shall not be considered competition for purposes of this 2004
         ASX Plan); the Eligible  Person's  dishonesty,  or acting in any manner
         inconsistent  with the utmost good faith and loyalty in the performance
         of the Eligible Person's duties; conviction of the Eligible Person by a
         court of law of  competent  jurisdiction  for fraud,  misappropriation,
         embezzlement,  or any felony; failure of the Eligible Person to perform
         his  duties  to  the  reasonable  satisfaction  of the  Company  or its
         Subsidiaries.

12.      DEATH

         Except as otherwise determined by the Committee or provided in an Offer
         Document,  in the event an Eligible  Person  dies while  employed by or
         providing  service  to the  Company  or any  of its  Subsidiaries,  all
         unvested Options shall become 100% vested and any Option granted to him
         that has not previously  expired or been exercised shall be exercisable
         by the estate of such  Eligible  Person or by any  person who  acquired
         such  Option by bequest  or  inheritance,  at any time  within one year
         after the date of death of the Eligible  Person,  unless such Option is
         earlier  terminated  pursuant to its terms.  All Options not  exercised
         within such one year period shall be deemed cancelled and terminated on
         the first anniversary of the Eligible Person's death.

13.      DISABILITY

         Except as otherwise determined by the Committee or provided in an Offer
         Document,  in the event of the termination of employment of an Eligible
         Person due to total disability,  the Eligible Person or his guardian or
         legal representative, shall have the right to exercise any Option which
         has not been  previously  exercised  or expired and which the  Eligible
         Person  was  eligible  to  exercise  as of  the  first  date  of  total
         disability, at any time within one year after such termination,  unless
         such Option is earlier  terminated  pursuant to its terms.  All Options
         that  are  not  exercisable  as of the  date of the  Eligible  Person's
         termination or which are not exercised within one year thereafter shall
         be deemed cancelled and terminated as of such applicable date.

         Subject to compliance with the Listing Rules (particularly but not only
         Listing Rule 6.23),  the Committee may, in its  discretion,  extend the
         time  periods in, or waive the  application  of any  provision of Rules
         11,12 or 13.

14.      ADJUSTMENTS

         Except in the case of a Change of Control of the Company as provided in
         Section 9, in the event that the  Committee  shall  determine  that any
         dividend or other  distribution  (whether in the form of cash,  shares,
         other securities,  or other property),  recapitalisation,  share split,
         reverse share split, reorganisation,  merger, consolidation,  split-up,
         spin-off,  combination,  repurchase,  or  exchange  of  shares or other
         securities,  the issuance of option or other rights to purchase  shares
         or other securities,  or other similar  corporate  transaction or event
         affects the shares with respect to which





         Options have been or may be issued  under the 2004 ASX Plan,  such that
         an adjustment is determined by the Committee to be appropriate in order
         to  prevent  dilution  or  enlargement  of the  benefits  or  potential
         benefits  intended to be made available  under the 2004 ASX Plan,  then
         the  Committee  shall,  in  such  manner  as  the  Committee  may  deem
         equitable,  adjust any or all of (i) the number and type of shares that
         thereafter may be made the subject of Options, (ii) the number and type
         of shares subject to outstanding  Options, and (iii) the exercise price
         with respect to any Option, or, if deemed  appropriate,  make provision
         for a cash payment to the holder of any outstanding  Option;  provided,
         however, that the number of shares subject to any Option denominated in
         shares shall always be a whole number.

15.      RIGHT OF DISCHARGE RESERVED

         Nothing in the 2004 ASX Plan nor the  issuance  Shares nor the grant of
         Options  hereunder shall confer upon any employee,  officer,  director,
         consultant,  independent  contractor or other  individual  the right to
         continue in the employment of or service with the Company or any of its
         Subsidiaries or affect any right that the Company or any Subsidiary may
         have to  terminate  the  employment  or  service of (or to demote or to
         exclude from future Options under the 2004 ASX Plan) any such employee,
         officer,   director,   consultant,   independent  contractor  or  other
         individual at any time for any reason.  Except as specifically provided
         by the  Committee,  the  Company  shall not be  liable  for the loss of
         existing or potential profit from an issuance or grant of securities in
         the  event  of  termination  of  an  employment  or  service  or  other
         relationship  even if the  termination is in violation of an obligation
         of the  Company  or any  Subsidiary  of the  Company  to the  employee,
         officer, director, consultant or independent contractor.

16.      SEVERABILITY

         If any  provision  of the  2004  ASX Plan  shall  be held  unlawful  or
         otherwise   invalid  or   unenforceable  in  whole  or  in  part,  such
         unlawfulness, invalidity or unenforceability shall not affect any other
         provision of the 2004 ASX Plan or part thereof, each of which remain in
         full force and effect. If the making of any payment or the provision of
         any  other  benefit  required  under  the 2004  ASX Plan  shall be held
         unlawful or  otherwise  invalid or  unenforceable,  such  unlawfulness,
         invalidity or  unenforceability  shall not prevent any other payment or
         benefit  from being made or  provided  under the 2004 ASX Plan,  to the
         extent that it would not be unlawful, invalid or unenforceable, and the
         maximum  payment or  benefit  that  would not be  unlawful,  invalid or
         unenforceable shall be made or provided under the 2004 ASX Plan.

17.      AMENDMENT AND TERMINATION OF THE 2004 ASX PLAN

         The Board of Directors may, from time to time, alter, amend, suspend or
         terminate the 2004 ASX Plan with respect to Shares or Options that have
         not been granted,  subject to any requirement for shareholder  approval
         imposed  by  applicable  law  or any  rule  of any  stock  exchange  or
         quotation  system  on which  shares  are  listed or  quoted;  provided,
         however, that the Board of Directors may not amend the 2004 ASX Plan in
         any manner that would result in non-compliance with any applicable law.
         Neither  the Board of  Directors  nor the  Committee  may,  without the
         consent of the Eligible  Person,  alter or in any way impair the rights
         of such Eligible Person under any issue previously granted. Neither the
         termination  of the  2004 ASX Plan nor the  Change  of  Control  of the
         Company shall affect any Option previously granted.

         If the  approval  of the  2004  ASX  Plan  by the  shareholders  is not
         obtained, the 2004 ASX Plan shall be null and void and each issue of an
         Share or Options hereunder shall be null and void.

18.      GENDER AND NUMBER

         Any  reference  to  masculine  terminology  used in this  2004 ASX Plan
         document  shall also include the  feminine,  and the  definition of any
         term herein in the singular  shall also include the plural  except when
         otherwise indicated by the context.

19.      GOVERNING LAW

         The  2004  ASX  Plan and all  determinations  made  and  actions  taken
         thereunder,  are  governed by  Australian  Corporations  Act 2001,  ASX
         Listing Rules and any other Federal or State laws of Australia.
































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                                                                          ITEM 2



        Resolution 1 Re-Election of Mr. Geoffrey Kempler to Serve as a Director
        Resolution 2 Election of Dr. Jonas Alsenas to Serve as a Director
        Resolution 3 Approval of Previous Issuance of Ordinary Shares to P.N. 
                     Gesolymalos S.A.
        Resolution 4 Approval of Previous Issuance of Ordinary Shares to Certain
                     Consultants
        Resolution 5 Approval of Previous Grants of Options to Certain 
                     Consultants
        Resolution 6 Approval of Previous Grants of Options to Certain Employees
        Resolution 7 Approval of Issuance of Warrants to Rodman & Renshaw LLC
        Resolution 8 Approval of Grant of Unlisted Options to Dr. Jonas Alsenas
        Resolution 9 Non-Executive Directors Remuneration Pool
        Resolution 10 Adoption of the 2004 American Depositary Share (ADS) 
                      Option Plan
        Resolution 11 Adoption of the 2004 Employees, Directors' and Consultants
                      Share and Option Plan
        Resolution 12 Adoption of Maximum Shares issuable under the 2004 
                      American Depositary Share (ADS) Option Plan and the 2004
                      Employees, Directors' and Consultants Share and Option 
                      Plan
        Resolution 13 Approval of Grant of Unlisted Options to Mr. Geoffrey 
                      Kempler
        Resolution 14 Approval of Grant of Unlisted Options to Prof. Colin 
                      Masters
        Resolution 15 Approval of Grant of Unlisted Options to Mr. Brian Meltzer
        Resolution 16 Approval of Grant of Unlisted Options to Dr. George Mihaly
        Resolution 17 Approval of Issuance of Ordinary Shares to Mr. Brian 
                      Meltzer in Lieu of Director's Base Fees
        Resolution 18 Approval of Issuance of Ordinary Shares to Dr. George
                      Mihaly in Lieu of Director's Base Fees
        Resolution 19 Approval of Issuance of Ordinary Shares to Prof. Colin 
                      Masters in Lieu of Director's Base Fees



                             DETACH PROXY CARD HERE

Mark, Sign, Date and Return                 [X]
the Proxy Card Promptly             Votes must be indicated
Using the Enclosed Envelope.        (x) in Black or Blue ink.

      FOR    AGAINST   ABSTAIN        FOR     AGAINST  ABSTAIN  
1.   [  ]     [  ]      [  ]   6.    [  ]      [  ]     [  ]    
2.   [  ]     [  ]      [  ]   7.    [  ]      [  ]     [  ]    
3.   [  ]     [  ]      [  ]   8.    [  ]      [  ]     [  ]    
4.   [  ]     [  ]      [  ]   9.    [  ]      [  ]     [  ]    
5.   [  ]     [  ]      [  ]   10.   [  ]      [  ]     [  ]    

     FOR     AGAINST   ABSTAIN        FOR     AGAINST  ABSTAIN 
11.  [  ]     [  ]      [  ]   16.   [  ]      [  ]     [  ]  
12.  [  ]     [  ]      [  ]   17.   [  ]      [  ]     [  ]  
13.  [  ]     [  ]      [  ]   18.   [  ]      [  ]     [  ]  
14.  [  ]     [  ]      [  ]   19.   [  ]      [  ]     [  ]  
15.  [  ]     [  ]      [  ]                                       
                             To change your address, please mark this box. [ ]

                                                     [SCAN LINE]

                    The Voting Instruction must be signed by the person in whose
                    name the relevant  Receipt is registered on the books of the
                    Depositary.  In  the  case  of  a  Corporation,  the  Voting
                    Instruction must be executed by a duly authorized Officer or
                    Attorney.

                    --------------------------------     -----------------------
                    Date       Share Owner sign here     Co-Owner sign here







                           PRANA BIOTECHNOLOGY LIMITED

               Instructions to The Bank of New York, as Depositary
     (Must be received prior to the close of business on November 10, 2004)

     The  undersigned  holder  of  one  or  more  American  Depositary  Receipts
("Receipts")  of PRANA  BIOTECHNOLOGY  LIMITED (the  "Company")  ordinary shares
hereby  requests and instructs The Bank of New York, as  Depositary,  to vote or
cause to be voted the number of shares  represented  by such  Receipt(s)  of the
Company,  registered  in  the  name  of the  undersigned  on  the  books  of the
Depositary as of the close of business  October 21, 2004, at the Annual  General
Meeting  of the  Company  to be held on  November  17,  2004,  in respect of the
resolutions specified on the reverse side.

NOTE:

      If no  instructions  are  received by the  Depositary  from any Owner with
      respect to any of the  Deposited  Securities  represented  by the American
      Depositary Shares evidenced by such Owner's Receipts on or before November
      10, 2004,  the  Depositary  shall deem such Owner to have  instructed  the
      Depositary  to give a  discretionary  proxy to a person  designated by the
      Company.

To include any comments, please mark this box. [ ]

Please  complete  and date this proxy on the reverse side and return it promptly
in the accompanying envelope.




                                   SIGNATURES


         Pursuant to the requirements of the Securities Exchange Act of 1934,
the registrant has duly caused this report to be signed on its behalf by the
undersigned, thereunto duly authorized.


                                            PRANA BIOTECHNOLOGY LIMITED
                                            ---------------------------
                                                 (Registrant)



                                            By:/s/Jonas V. Alsenas
                                               ------------------- 
                                                  Jonas V. Alsenas
                                                  Chief Executive Officer



Date:  November 3, 2004