Ownership Submission
FORM 4
Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).
UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940
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(Print or Type Responses)
1. Name and Address of Reporting Person *
GROGAN THOMAS
  2. Issuer Name and Ticker or Trading Symbol
VENTANA MEDICAL SYSTEMS INC [VMSI]
5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)
__X__ Director _____ 10% Owner
_____ Officer (give title below) _____ Other (specify below)
(Last)
(First)
(Middle)
1910 E. INNOVATION PARK DR
3. Date of Earliest Transaction (Month/Day/Year)
02/19/2008
(Street)

TUCSON, AZ 85755
4. If Amendment, Date Original Filed(Month/Day/Year)
6. Individual or Joint/Group Filing(Check Applicable Line)
_X_ Form filed by One Reporting Person
___ Form filed by More than One Reporting Person
(City)
(State)
(Zip)
Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1.Title of Security
(Instr. 3)
2. Transaction Date (Month/Day/Year) 2A. Deemed Execution Date, if any (Month/Day/Year) 3. Transaction Code
(Instr. 8)
4. Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4 and 5)
5. Amount of Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 3 and 4)
6. Ownership Form: Direct (D) or Indirect (I)
(Instr. 4)
7. Nature of Indirect Beneficial Ownership
(Instr. 4)
Code V Amount (A) or (D) Price

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
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Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned
(e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security
(Instr. 3)
2. Conversion or Exercise Price of Derivative Security 3. Transaction Date (Month/Day/Year) 3A. Deemed Execution Date, if any (Month/Day/Year) 4. Transaction Code
(Instr. 8)
5. Number of Derivative Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4, and 5)
6. Date Exercisable and Expiration Date
(Month/Day/Year)
7. Title and Amount of Underlying Securities
(Instr. 3 and 4)
8. Price of Derivative Security
(Instr. 5)
9. Number of Derivative Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 4)
10. Ownership Form of Derivative Security: Direct (D) or Indirect (I)
(Instr. 4)
11. Nature of Indirect Beneficial Ownership
(Instr. 4)
Code V (A) (D) Date Exercisable Expiration Date Title Amount or Number of Shares
Stock Options (Right to Buy) $ 10.06 02/19/2008   D     2,820 01/22/2002(1) 01/22/2012 Common Stock 2,820 $ 79.44 0 D  
Stock Option (Right to Buy) $ 40.25 02/19/2008   D     18,000 03/28/2007(2) 02/28/2017 Common Stock 18,000 $ 49.25 0 D  
Stock Options (Right to Buy) $ 42.41 02/19/2008   D     3,100 12/15/2005(3) 12/15/2015 Common Stock 3,100 $ 47.09 0 D  
Stock Options (Right to Buy) $ 44.43 02/19/2008   D     3,100 12/15/2005(3) 12/15/2015 Common Stock 3,100 $ 45.07 0 D  
Stock Options (Right to Buy) $ 46.45 02/19/2008   D     3,100 12/15/2005(3) 12/15/2015 Common Stock 3,100 $ 43.05 0 D  
Stock Options (Right to Buy) $ 48.47 02/19/2008   D     3,100 12/15/2005(3) 12/15/2015 Common Stock 3,100 $ 41.03 0 D  
Stock Options (Right to Buy) $ 50.49 02/19/2008   D     3,100 12/15/2005(3) 12/15/2015 Common Stock 3,100 $ 39.01 0 D  
Stock Options (Right to Buy) $ 33.73 02/19/2008   D     3,400 12/28/2004(4) 12/28/2014 Common Stock 3,400 $ 55.77 0 D  
Stock Options (Right to Buy) $ 35.42 02/19/2008   D     3,400 12/28/2004(4) 12/28/2014 Common Stock 3,400 $ 54.08 0 D  
Stock Options (Right to Buy) $ 37.19 02/19/2008   D     3,400 12/28/2004(4) 12/28/2014 Common Stock 3,400 $ 52.31 0 D  
Stock Options (Right to Buy) $ 39.05 02/19/2008   D     3,400 12/28/2004(4) 12/28/2014 Common Stock 3,400 $ 50.45 0 D  
Stock Options (Right to Buy) $ 41 02/19/2008   D     3,400 12/28/2004(4) 12/28/2014 Common Stock 3,400 $ 48.5 0 D  
Stock Options (Right to Buy) $ 10.06 02/19/2008   D     18,798 01/22/2002(5) 01/22/2012 Common Stock 18,798 $ 79.44 0 D  
Stock Options (Right to Buy) $ 22.365 02/19/2008   D     17,409 01/26/2004(6) 01/26/2014 Common Stock 17,409 $ 67.135 0 D  
Stock Options (Right to Buy) $ 22.365 02/19/2008   D     21,070 01/26/2004(6) 01/26/2014 Common Stock 21,070 $ 67.135 0 D  
Stock Options (Right to Buy) $ 12.115 02/19/2008   D     27,000 05/03/2000(7) 05/03/2010 Common Stock 27,000 $ 77.385 0 D  
Stock Options (Right to Buy) $ 13.188 02/19/2008   D     29,220 10/30/2000(8) 10/30/2010 Common Stock 29,220 $ 76.312 0 D  
Stock Options (Right to Buy) $ 10.12 02/19/2008   D     14,000 01/27/2003(9) 01/27/2013 Common Stock 14,000 $ 79.38 0 D  
Stock Options (Right to Buy) $ 10.12 02/19/2008   D     8,212 01/27/2003(9) 01/27/2013 Common Stock 8,212 $ 79.38 0 D  

Reporting Owners

Reporting Owner Name / Address Relationships
 Director  10% Owner  Officer  Other
GROGAN THOMAS
1910 E. INNOVATION PARK DR
TUCSON, AZ 85755
  X      

Signatures

 Lelslie Oaks, Attorney in Fact for Thomas Grogan   02/19/2008
**Signature of Reporting Person Date

Explanation of Responses:

* If the form is filed by more than one reporting person, see Instruction 4(b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
(1) This option, which vested 20% after 12 months and 1/60th each month thereafter commencing on January 22,2002, was cancelled in the merger in exchange for a cash payment equal to the product of (a) the excess of $89.50 over the applicable exercise price and (b) the number of shares subject to the option, reduced by applicable withholding taxes.
(2) This option, which provided for monthly vesting begining March 28, 2007, was cancelled in the merger in exchange for a cash payment equal to the product of (a) the excess of $89.50 over the applicable exercise price and (b) the number of shares subject to the option, reduced by applicable withholding taxes.
(3) This option, which was fully vested at grant on December 15, 2005, was cancelled in the merger in exchange for a cash payment equal to the product of (a) the excess of $89.50 over the applicable exercise price and (b) the number of shares subject to the option, reduced by applicable withholding taxes.
(4) This option, which was fully vested at grant on December 28, 2004, was cancelled in the merger in exchange for a cash payment equal to the product of (a) the excess of $89.50 over the applicable exercise price and (b) the number of shares subject to the option, reduced by applicable withholding taxes.
(5) This option, which vested 20% after 12 months and 1/60th each month thereafter commencing on January 22, 2002, was cancelled in the merger in exchange for a cash payment equal to the product of (a) the excess of $89.50 over the applicable exercise price and (b) the number of shares subject to the option, reduced by applicable withholding taxes.
(6) This option, which vested 20% after 12 months and 1/60th each month thereafter commencing on January 26, 2004, was cancelled in the merger in exchange for a cash payment equal to the product of (a) the excess of $89.50 over the applicable exercise price and (b) the number of shares subject to the option, reduced by applicable withholding taxes.
(7) This option, which vested montly commencing on May 3, 2000, was cancelled in the merger in exchange for a cash payment equal to the product of (a) the excess of $89.50 over the applicable exercise price and (b) the number of shares subject to the option, reduced by applicable withholding taxes.
(8) This option, which vested 20% after 12 months and 1/60th each month thereafter commencing on October 30, 2000, was cancelled in the merger in exchange for a cash payment equal to the product of (a) the excess of $89.50 over the applicable exercise price and (b) the number of shares subject to the option, reduced by applicable withholding taxes.
(9) This option, which vested 20% after 12 months and 1/60th each month thereafter commencing on January 27, 2003, was cancelled in the merger in exchange for a cash payment equal to the product of (a) the excess of $89.50 over the applicable exercise price and (b) the number of shares subject to the option, reduced by applicable withholding taxes.

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