PAGE  1
000 A000000 09/30/2014
000 C000000 0000790202
000 D000000 N
000 E000000 NF
000 F000000 Y
000 G000000 N
000 H000000 N
000 I000000 6.1
000 J000000 A
001 A000000 FIRST OPPORTUNITY FUND, INC.
001 B000000 811-4605
001 C000000 3034445483
002 A000000 2344 SPRUCE STREET, SUITE A
002 B000000 BOULDER
002 C000000 CO
002 D010000 80302
003  000000 N
004  000000 N
005  000000 N
006  000000 N
007 A000000 N
007 B000000  0
008 A000001 STEWART WEST INDIES TRADING COMPANY, LTD
008 B000001 A
008 C000001 801-56522
008 D010001 ST. PETER
008 D050001 BARBADOS
008 A000002 ROCKY MOUNTAIN ADVISERS, LLC
008 B000002 A
008 C000002 801-70202
008 D010002 BOULDER
008 D020002 CO
008 D030002 80302
010 A000001 FUND ADMINISTRATIVE SERVICES, LLC
010 B000001 84-1282398
010 C010001 BOULDER
010 C020001 CO
010 C030001 80302
010 A000002 ALPS FUND SERVICES, INC.
010 B000002 84-5730
010 C010002 DENVER
010 C020002 CO
010 C030002 80203
012 A000001 COMPUTERSHARE TRUST COMPANY, NA
012 B000001 85-11340
012 C010001 CANTON
012 C020001 MA
012 C030001 02021
013 A000001 DELOITTE & TOUCHE LLP
013 B010001 DENVER
013 B020001 CO
      PAGE  2
013 B030001 80202
015 A000001 BANK OF NEW YORK MELLON
015 B000001 C
015 C010001 NEW YORK
015 C020001 NY
015 C030001 10286
015 E010001 X
015 A000002 NATIONAL AUSTRALIA BANK
015 B000002 S
015 C010002 MELBOURNE
015 D010002 AUSTRALIA
015 E040002 X
015 A000003 SKANDINAVISKA ENSKILDA BANKEN AB
015 B000003 S
015 C010003 COPENHAGEN
015 D010003 DENMARK
015 E040003 X
015 A000004 BNP PARIBAS SECURITIES SERVICES
015 B000004 S
015 C010004 PARIS
015 D010004 FRANCE
015 E040004 X
015 A000005 BANK OF NEW YORK, LONDON
015 B000005 S
015 C010005 LONDON
015 D010005 ENGLAND
015 E040005 X
015 A000006 HONG KONG AND SHANGHAI BANKING CORPORATION
015 B000006 S
015 C010006 KOWLOON
015 D010006 HONG KONG
015 E040006 X
015 A000007 DEUTSCHE BANK, AG (INDIA)
015 B000007 S
015 C010007 MUMBAI
015 D010007 INDIA
015 E040007 X
015 A000008 BANK OF TOKYO
015 B000008 S
015 C010008 TOKYO
015 D010008 JAPAN
015 E040008 X
015 A000009 NATIONAL AUSTRALIA BANK NEW ZEALAND-NATIONAL
015 B000009 S
015 C010009 WELLINGTON
015 D010009 NEW ZEALAND
015 E040009 X
015 A000010 DEUTSCHE BANK (TURKEY)
015 B000010 S
015 C010010 ISTANBUL
015 D010010 TURKEY
      PAGE  3
015 E040010 X
015 A000011 DEUTSCHE BANK, AG (JAKARTA)
015 B000011 S
015 C010011 JAKARTA
015 D010011 INDONESIA
015 E040011 X
015 A000012 EUROCLEAR
015 B000012 S
015 C010012 BRUSSELS
015 D010012 BELGIUM
015 E040012 X
015 A000013 CLEARSTREAM BANKING S.A.
015 B000013 S
015 C010013 FRANKFURT
015 D010013 GERMANY
015 E040013 X
018  000000 Y
019 A000000 Y
019 B000000    4
019 C000000 BOULDERINV
020 A000001 BNY CONVERGEX EXECUTION SOLUTIONS LLC
020 B000001 13-3989198
020 C000001       3
020 A000002 KNIGHT CAPITAL GROUP
020 B000002 22-3660471
020 C000002       2
020 A000003 BLOOMBERG TRADEBOOK LLC
020 B000003 13-3880286
020 C000003       2
021  000000         7
022 A000001 DREYFUS TREASURY CASH MANAGEMENT
022 C000001      16477
022 D000001      22314
022 A000002 JP MORGAN PRIME MONEY MARKET FUND
022 C000002       9800
022 D000002       7250
023 C000000       26277
023 D000000       29564
024  000000 Y
025 A000001 JP MORGAN CHASE & CO.
025 B000001 13-2624428
025 C000001 E
025 D000001    18301
025 A000002 DREYFUS TREASURY & AGENCY CASH MANAGMENT MONE
025 C000002 E
025 D000002     2652
025 A000003 JP MORGAN PRIME MONEY MARKET FUND
025 C000003 E
025 D000003     5550
025 A000004 WELLS FARGO BROKERAGE SERVICES LLC
025 B000004 41-1508325
      PAGE  4
025 C000004 E
025 D000004    21774
026 A000000 N
026 B000000 N
026 C000000 N
026 D000000 Y
026 E000000 N
026 F000000 N
026 G010000 N
026 G020000 N
026 H000000 N
027  000000 N
045  000000 Y
046  000000 Y
047  000000 Y
048  000000  1.250
048 A010000         0
048 A020000 0.000
048 B010000         0
048 B020000 0.000
048 C010000         0
048 C020000 0.000
048 D010000         0
048 D020000 0.000
048 E010000         0
048 E020000 0.000
048 F010000         0
048 F020000 0.000
048 G010000         0
048 G020000 0.000
048 H010000         0
048 H020000 0.000
048 I010000         0
048 I020000 0.000
048 J010000         0
048 J020000 0.000
048 K010000         0
048 K020000 0.000
049  000000 N
050  000000 N
051  000000 N
052  000000 N
053 A000000 Y
053 B000000 Y
053 C000000 N
054 A000000 Y
054 B000000 Y
054 C000000 N
054 D000000 N
054 E000000 N
054 F000000 N
      PAGE  5
054 G000000 Y
054 H000000 Y
054 I000000 N
054 J000000 Y
054 K000000 N
054 L000000 N
054 M000000 N
054 N000000 N
054 O000000 Y
055 A000000 N
055 B000000 N
056  000000 Y
057  000000 N
058 A000000 N
059  000000 Y
060 A000000 N
060 B000000 N
061  000000         0
062 A000000 N
062 B000000   0.0
062 C000000   0.0
062 D000000   0.0
062 E000000   0.0
062 F000000   0.0
062 G000000   0.0
062 H000000   0.0
062 I000000   0.0
062 J000000   0.0
062 K000000   0.0
062 L000000   0.0
062 M000000   0.0
062 N000000   0.0
062 O000000   0.0
062 P000000   0.0
062 Q000000   0.0
062 R000000   0.0
066 A000000 Y
066 B000000 N
066 C000000 N
066 D000000 N
066 E000000 N
066 F000000 N
066 G000000 Y
067  000000 N
068 A000000 N
068 B000000 N
069  000000 N
070 A010000 Y
070 A020000 N
070 B010000 Y
070 B020000 N
      PAGE  6
070 C010000 Y
070 C020000 N
070 D010000 Y
070 D020000 N
070 E010000 N
070 E020000 N
070 F010000 N
070 F020000 N
070 G010000 Y
070 G020000 N
070 H010000 N
070 H020000 N
070 I010000 Y
070 I020000 N
070 J010000 Y
070 J020000 Y
070 K010000 Y
070 K020000 Y
070 L010000 Y
070 L020000 Y
070 M010000 Y
070 M020000 Y
070 N010000 Y
070 N020000 N
070 O010000 Y
070 O020000 N
070 P010000 Y
070 P020000 N
070 Q010000 Y
070 Q020000 N
070 R010000 Y
070 R020000 N
071 A000000      25578
071 B000000     118571
071 C000000     318992
071 D000000    8
072 A000000  6
072 B000000         2
072 C000000      3014
072 D000000         0
072 E000000         0
072 F000000      1605
072 G000000       376
072 H000000         0
072 I000000        11
072 J000000        14
072 K000000         0
072 L000000        16
072 M000000        50
072 N000000         0
072 O000000         0
      PAGE  7
072 P000000         0
072 Q000000         0
072 R000000        70
072 S000000        73
072 T000000         0
072 U000000         0
072 V000000         0
072 W000000        76
072 X000000      2291
072 Y000000       117
072 Z000000       842
072AA000000     39788
072BB000000         0
072CC010000         0
072CC020000     36374
072DD010000         0
072DD020000         0
072EE000000         0
073 A010000    0.0000
073 A020000    0.0000
073 B000000    0.0000
073 C000000    0.0000
074 A000000        53
074 B000000         0
074 C000000         0
074 D000000         0
074 E000000         0
074 F000000    222601
074 G000000         0
074 H000000         0
074 I000000     11214
074 J000000    115281
074 K000000         0
074 L000000       253
074 M000000        37
074 N000000    349439
074 O000000         0
074 P000000       297
074 Q000000         0
074 R010000         0
074 R020000         0
074 R030000         0
074 R040000       163
074 S000000         0
074 T000000    348979
074 U010000     28739
074 U020000         0
074 V010000     12.14
074 V020000      0.00
074 W000000    0.0000
074 X000000       476
      PAGE  8
074 Y000000         0
075 A000000         0
075 B000000    348595
076  000000      9.69
077 A000000 Y
077 C000000 Y
077 Q010000 Y
078  000000 Y
080 C000000         0
081 B000000    0
086 A010000       0
086 A020000       0
086 B010000       0
086 B020000       0
086 C010000       0
086 C020000       0
086 D010000       0
086 D020000       0
086 E010000       0
086 E020000       0
086 F010000       0
086 F020000       0
087 A010000 Common Stock
088 A000000 N
088 B000000 N
088 C000000 N
088 D000000 N
SIGNATURE   Nicole Murphey
TITLE       Assistant Treasurer