[
]
|
Rule
13d-1(b)
|
|
[X]
|
Rule
13d-1(c)
|
|
[
]
|
Rule
13d-1(d)
|
CUSIP
No. 249908104
|
13G
|
Page
2 of 7 Pages
|
||||
|
||||||
|
1.
|
Names
of Reporting Persons.
I.R.S.
Identification Nos. of above persons (entities only).
RA
Capital Management, LLC
|
||||
|
||||||
2.
|
Check
the Appropriate Box if a Member of a Group (See
Instructions)
|
|||||
(a)
|
o | |||||
(b)
|
o | |||||
|
||||||
3.
|
SEC
Use Only
|
|||||
|
||||||
4.
|
Citizenship
or Place of
Organization Massachusetts
|
|||||
|
||||||
Number
of
Shares
Beneficially
Owned
by
Each
Reporting
Person
With
|
5.
|
Sole
Voting
Power 2,686,552
|
||||
|
||||||
6.
|
Shared
Voting
Power 0
|
|||||
|
||||||
7.
|
Sole
Dispositive
Power 2,686,552
|
|||||
|
||||||
8.
|
Shared
Dispositive
Power 0
|
|||||
|
||||||
9.
|
Aggregate
Amount Beneficially Owned by Each Reporting Person
2,686,552
|
|||||
|
||||||
10.
|
Check
if the Aggregate Amount in Row (9) Excludes
o
Certain
Shares (See Instructions)
|
|||||
|
||||||
11.
|
Percent
of Class Represented by Amount in Row (9)
5.2%
|
|||||
|
||||||
12.
|
Type
of Reporting Person (See Instructions)
IA
|
|||||
|
CUSIP
No. 249908104
|
13G
|
Page
3 of 7 Pages
|
||||
|
||||||
|
1.
|
Names
of Reporting Persons.
I.R.S.
Identification Nos. of above persons (entities only).
Peter
Kolchinsky
|
||||
|
||||||
2.
|
Check
the Appropriate Box if a Member of a Group (See
Instructions)
|
|||||
(a)
|
o | |||||
(b)
|
o | |||||
|
||||||
3.
|
SEC
Use Only
|
|||||
|
||||||
4.
|
Citizenship
or Place of
Organization United
States
|
|||||
|
||||||
Number
of
Shares
Beneficially
Owned
by
Each
Reporting
Person
With
|
5.
|
Sole
Voting
Power 2,686,552
|
||||
|
||||||
6.
|
Shared
Voting
Power 0
|
|||||
|
||||||
7.
|
Sole
Dispositive
Power 2,686,552
|
|||||
|
||||||
8.
|
Shared
Dispositive
Power 0
|
|||||
|
||||||
9.
|
Aggregate
Amount Beneficially Owned by Each Reporting Person
2,686,552
|
|||||
|
||||||
10.
|
Check
if the Aggregate Amount in Row (9) Excludes
o
Certain
Shares (See Instructions)
|
|||||
|
||||||
11.
|
Percent
of Class Represented by Amount in Row (9)
5.2%
|
|||||
|
||||||
12.
|
Type
of Reporting Person (See Instructions)
IN
|
|||||
|
CUSIP
No. 249908104
|
13G
|
Page
4 of 7 Pages
|
||||
|
||||||
|
1.
|
Names
of Reporting Persons.
I.R.S.
Identification Nos. of above persons (entities only).
RA
Capital Healthcare Fund, L.P.
|
||||
|
||||||
2.
|
Check
the Appropriate Box if a Member of a Group (See
Instructions)
|
|||||
(a)
|
o | |||||
(b)
|
o | |||||
|
||||||
3.
|
SEC
Use Only
|
|||||
|
||||||
4.
|
Citizenship
or Place of
Organization Delaware
|
|||||
|
||||||
Number
of
Shares
Beneficially
Owned
by
Each
Reporting
Person
With
|
5.
|
Sole
Voting
Power 1,817,268
|
||||
|
||||||
6.
|
Shared
Voting
Power 0
|
|||||
|
||||||
7.
|
Sole
Dispositive
Power 1,817,268
|
|||||
|
||||||
8.
|
Shared
Dispositive
Power 0
|
|||||
|
||||||
9.
|
Aggregate
Amount Beneficially Owned by Each Reporting Person
1,817,268
|
|||||
|
||||||
10.
|
Check
if the Aggregate Amount in Row (9) Excludes
o
Certain
Shares (See Instructions)
|
|||||
|
||||||
11.
|
Percent
of Class Represented by Amount in Row (9)
3.5%
|
|||||
|
||||||
12.
|
Type
of Reporting Person (See Instructions)
PN
|
|||||
|
CUSIP
No. 249908104
|
Page
5 of 7
|
CUSIP
No. 249908104
|
Page
6 of 7
|
CUSIP
No. 249908104
|
Page
7 of 7
|